FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946245759> ?p ?o ?g. }

• W2946245759 endingPage "308" @default.
• W2946245759 startingPage "307" @default.
• W2946245759 abstract "To the Editor: Granulomatous vasculitis in skin lesions is rarely seen in cutaneous sarcoidosis and other inflammatory skin disorders. We herein report a case of necrobiosis lipoidica, in which granulomatous phlebitis was observed in a muscular vein at the dermo–subcutaneous junction. A 59-year-old woman visited our hospital, complaining of asymptomatic eruptions of the lower extremities, which had appeared 3 years previously. She had been suffering from diabetes mellitus for several years and treated with oral hypoglycemic agents. Physical examination showed several well-circumscribed waxy brownish infiltrated plaques with elevated borders on the bilateral shins (Fig. 1A). Histological examination revealed necrobiotic changes of collagen in the dermis, surrounded by inflammatory granulomatous reaction composed of lymphocytes, histiocytes, and multinucleated giant cells (Figs. 1B, C). Furthermore, a muscular vein at the dermo–subcutaneous junction was surrounded by multinucleated giant cells in a style of a marked angiocentric infiltrate in and around the affected vessel wall with partial destruction of the muscular layer, which were consistent with the features of granulomatous phlebitis (Fig. 1D). Elastica van Gieson staining also confirmed that the involved vessel was a vein. Dermal mucin deposition was not detected. Immunohistochemistry results showed that the histiocytes in and around the affected vessel wall were immunoreactive for CD68 (Fig. 1E). On laboratory examination, the serum level of angiotensin-converting enzyme was normal, and neither PR3-ANCA nor MPO-ANCA was detected. Ophthalmological and pulmonary examination excluded sarcoidosis. The patient was treated with a topical difluprednate ointment, which, however, was not sufficiently effective.FIGURE 1.: A, Multiple waxy brownish plaques on the bilateral shins with slightly elevated erythema at the periphery. B, Histological features showing horizontally arranged palisading histiocytes and multinucleated giant cells surrounding degenerated collagen in the dermis (×40). C, Degenerated collagen surrounded by histiocytes and multinucleated giant cells (×40). D, Granulomatous phlebitis at the dermo–subcutaneous junction is characterized by a marked angiocentric infiltrate of histiocytes and multinucleated giant cells in and around the affected vessel wall with partial destruction of the muscular layer (×100). E, Intense CD68 staining also demonstrates a marked angiocentric infiltrate of histiocytes in and around the vessel wall (×200).Cutaneous disorders that histologically show granulomatous vasculitis include granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid arthritis, giant cell arteritis, Crohn disease, granulomatous phlebitis, and noninfectious granulomatous diseases such as sarcoidosis and necrobiosis lipoidica.1,2 In Ackerman's textbook,3 it is described that granulomatous vasculitis with histiocytes palisaded around vessels is observed in the deep dermis of necrobiosis lipoidica; however, there are very few reports of cases of necrobiosis lipoidica with granulomatous vasculitis. In ulcerative sarcoidosis, vasculitis is often suggested to be the cause. In a previous report of ulcerative necrobiosis lipoidica, giant cell chronic vasculitis was histologically revealed.4 By contrast, not all cases of ulcerative necrobiosis lipoidica show granulomatous vasculitis. Conversely, the present case did not present with ulcerative form, although granulomatous vasculitis was detected in the biopsied specimen. Phlebitis or thrombophlebitis in the lower legs is sometimes misdiagnosed as cutaneous arteritis because the veins in the lower legs have a compact concentric smooth muscle pattern with a round lumen and the intimal elastic fiber proliferation mimicking the characteristic features of arteritis.5 In the present case, the involved vessel was the muscular vein located at the dermo–subcutaneous junction. Magro et al6 suggested that the findings of active vasculopathy of leukocytoclastic, granulomatous, or thrombogenic subtypes in biopsied specimens of necrobiosis lipoidica or granuloma annulare should be considered as a manifestation of underlying systemic diseases. The pathogenesis of necrobiosis lipoidica is still uncertain; however, collagen degeneration, vascular changes, microangiopathy associated with diabetes, abnormalities in glucose transport by fibroblasts, impaired neutrophil migration, and inflammation triggered by altered metabolism or trauma have been speculated.7,8 Further studies regarding the association of granulomatous vasculitis with the clinical phenotypes of necrobiosis lipoidica are necessary." @default.
• W2946245759 created "2019-05-29" @default.
• W2946245759 creator A5045066749 @default.
• W2946245759 creator A5071869091 @default.
• W2946245759 date "2020-04-01" @default.
• W2946245759 modified "2023-09-28" @default.
• W2946245759 title "Granulomatous Phlebitis in Necrobiosis Lipoidica" @default.
• W2946245759 cites W1670188405 @default.
• W2946245759 cites W1966555727 @default.
• W2946245759 cites W2007172781 @default.
• W2946245759 cites W2008714417 @default.
• W2946245759 cites W2126738080 @default.
• W2946245759 cites W2155650333 @default.
• W2946245759 cites W4234426710 @default.
• W2946245759 doi "https://doi.org/10.1097/dad.0000000000001458" @default.
• W2946245759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31124881" @default.
• W2946245759 hasPublicationYear "2020" @default.
• W2946245759 type Work @default.
• W2946245759 sameAs 2946245759 @default.
• W2946245759 citedByCount "1" @default.
• W2946245759 countsByYear W29462457592020 @default.
• W2946245759 crossrefType "journal-article" @default.
• W2946245759 hasAuthorship W2946245759A5045066749 @default.
• W2946245759 hasAuthorship W2946245759A5071869091 @default.
• W2946245759 hasBestOaLocation W29462457591 @default.
• W2946245759 hasConcept C108657112 @default.
• W2946245759 hasConcept C134018914 @default.
• W2946245759 hasConcept C142724271 @default.
• W2946245759 hasConcept C16005928 @default.
• W2946245759 hasConcept C204232928 @default.
• W2946245759 hasConcept C2776460901 @default.
• W2946245759 hasConcept C2777624698 @default.
• W2946245759 hasConcept C2779421657 @default.
• W2946245759 hasConcept C2779470898 @default.
• W2946245759 hasConcept C2779851298 @default.
• W2946245759 hasConcept C2780140890 @default.
• W2946245759 hasConcept C2781301800 @default.
• W2946245759 hasConcept C43100952 @default.
• W2946245759 hasConcept C555293320 @default.
• W2946245759 hasConcept C71924100 @default.
• W2946245759 hasConcept C77076574 @default.
• W2946245759 hasConceptScore W2946245759C108657112 @default.
• W2946245759 hasConceptScore W2946245759C134018914 @default.
• W2946245759 hasConceptScore W2946245759C142724271 @default.
• W2946245759 hasConceptScore W2946245759C16005928 @default.
• W2946245759 hasConceptScore W2946245759C204232928 @default.
• W2946245759 hasConceptScore W2946245759C2776460901 @default.
• W2946245759 hasConceptScore W2946245759C2777624698 @default.
• W2946245759 hasConceptScore W2946245759C2779421657 @default.
• W2946245759 hasConceptScore W2946245759C2779470898 @default.
• W2946245759 hasConceptScore W2946245759C2779851298 @default.
• W2946245759 hasConceptScore W2946245759C2780140890 @default.
• W2946245759 hasConceptScore W2946245759C2781301800 @default.
• W2946245759 hasConceptScore W2946245759C43100952 @default.
• W2946245759 hasConceptScore W2946245759C555293320 @default.
• W2946245759 hasConceptScore W2946245759C71924100 @default.
• W2946245759 hasConceptScore W2946245759C77076574 @default.
• W2946245759 hasIssue "4" @default.
• W2946245759 hasLocation W29462457591 @default.
• W2946245759 hasLocation W29462457592 @default.
• W2946245759 hasOpenAccess W2946245759 @default.
• W2946245759 hasPrimaryLocation W29462457591 @default.
• W2946245759 hasRelatedWork W1983162993 @default.
• W2946245759 hasRelatedWork W1985406598 @default.
• W2946245759 hasRelatedWork W2015678459 @default.
• W2946245759 hasRelatedWork W2075567380 @default.
• W2946245759 hasRelatedWork W2078248128 @default.
• W2946245759 hasRelatedWork W2276881984 @default.
• W2946245759 hasRelatedWork W2365181479 @default.
• W2946245759 hasRelatedWork W2398316427 @default.
• W2946245759 hasRelatedWork W2803565508 @default.
• W2946245759 hasRelatedWork W2946245759 @default.
• W2946245759 hasVolume "42" @default.
• W2946245759 isParatext "false" @default.
• W2946245759 isRetracted "false" @default.
• W2946245759 magId "2946245759" @default.
• W2946245759 workType "article" @default.