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- W2946260766 abstract "The importance of PG biosynthesis in aggregation has been studied by comparing PRP from normal and essential fatty acid deficient (EFAD) rats. The latter show a marked lack of the PG precursor, arachidonic acid (AA). No differences were observed in aggregation with collagen (from 10 μg/ml), ADP (from 0.8 μM) or the PG-endoperoxide PGH2 (1 μg/ml). PGH2 induced only a small, transient aggregation. However, with a collagen dose that produced a 50% response in normal PRP, the aggregation of EFAD PRP was 94% reduced. This correlated with reduced (84–89%) biosynthesis of thromboxane A2 and PGE-like material (PGE), both assessed by bioassay. The PG synthetase of EFAD PRP was unaltered, since PGE and malondialdehyde production were normal when exogenous AA was added. AA, up to 0.33 mM, did not aggregate normal PRP, but high amounts of PGE were formed. These results indicate that internal PG biosynthesis is only essential for aggregation with threshold doses of collagen. At higher collagen doses endogenous PG production does not seem to be important for aggregation. It is unlikely that residual formation of PG-endoperoxides in EFAD PRP, at high doses of collagen, is sufficient for a normal aggregation, since normal rat platelets form PG-endoperoxides from exogenous AA without aggregation." @default.
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- W2946260766 date "1977-01-01" @default.
- W2946260766 modified "2023-09-23" @default.
- W2946260766 title "Relationship Between Aggregation and Prostaglandin (PG)-Biosynthesis in Rat Platelet Rich Plasma (PRP)" @default.
- W2946260766 doi "https://doi.org/10.1055/s-0039-1680425" @default.
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