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- W2946262701 abstract "The recent rise in antibiotic and chemotherapeutic resistance necessitates the search for novel drugs. Potential therapeutics can be produced by specialized metabolism gene clusters (SMGCs). We mined for SMGCs in metagenomic samples from Atlantis II Deep, Discovery Deep and Kebrit Deep Red Sea brine pools. Shotgun sequence assembly and secondary metabolite analysis shell (antiSMASH) screening unraveled 2751 Red Sea brine SMGCs, pertaining to 28 classes. Predicted categorization of the SMGC products included those (1) commonly abundant in microbes (saccharides, fatty acids, aryl polyenes, acyl-homoserine lactones), (2) with antibacterial and/or anticancer effects (terpenes, ribosomal peptides, non-ribosomal peptides, polyketides, phosphonates) and (3) with miscellaneous roles conferring adaptation to the environment/special structure/unknown function (polyunsaturated fatty acids, ectoine, ladderane, others). Saccharide (80.49%) and putative (7.46%) SMGCs were the most abundant. Selected Red Sea brine pool sites had distinct SMGC profiles, e.g., for bacteriocins and ectoine. Top promising candidates, SMs with pharmaceutical applications, were addressed. Prolific SM-producing phyla (Proteobacteria, Actinobacteria, Cyanobacteria), were ubiquitously detected. Sites harboring the largest numbers of bacterial and archaeal phyla, had the most SMGCs. Our results suggest that the Red Sea brine niche constitutes a rich biological mine, with the predicted SMs aiding extremophile survival and adaptation." @default.
- W2946262701 created "2019-05-29" @default.
- W2946262701 creator A5007117666 @default.
- W2946262701 creator A5019613026 @default.
- W2946262701 creator A5022112517 @default.
- W2946262701 creator A5055109324 @default.
- W2946262701 date "2019-05-08" @default.
- W2946262701 modified "2023-09-25" @default.
- W2946262701 title "Insights into Red Sea Brine Pool Specialized Metabolism Gene Clusters Encoding Potential Metabolites for Biotechnological Applications and Extremophile Survival" @default.
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- W2946262701 doi "https://doi.org/10.3390/md17050273" @default.
- W2946262701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6562949" @default.
- W2946262701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31071993" @default.
- W2946262701 hasPublicationYear "2019" @default.
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