FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946323141> ?p ?o ?g. }

• W2946323141 abstract "Background The VITALITY-HFpEF trial (Evaluate the Efficacy and Safety of the Oral sGC Stimulator Vericiguat to Improve Physical Functioning in Daily Living Activities of Patients With Heart Failure and Preserved Ejection Fraction) is designed to determine the efficacy and safety of a novel oral soluble guanylate cyclase stimulator, vericiguat, on quality of life and exercise tolerance in heart failure patients with preserved ejection fraction (HFpEF). Impaired physical functioning reduces the quality of life in patients with HFpEF. The primary goal of HF treatment along with improving survival is to improve function, reduce symptoms, and maximize quality of life. Abnormal cyclic guanosine monophosphate signaling may contribute to physical limitations in patients with HFpEF via central and peripheral mechanisms. Exploratory post hoc analyses from a prior trial showed that vericiguat can improve patient-relevant domains of the Kansas City Cardiomyopathy Questionnaire, especially the physical limitation score. Methods and Results VITALITY-HFpEF is a placebo-controlled, double-blind, multi-center, phase IIb trial of ≈735 patients, ≥45 years with HFpEF and ejection fraction ≥45% who will be randomized 1:1:1 to placebo, 10 mg, or 15 mg vericiguat. The primary end point is change in Kansas City Cardiomyopathy Questionnaire physical limitation score from baseline to week 24 and change in 6-minute walk test from baseline to week 24 is the secondary end point. Conclusions VITALITY-HFpEF is the first trial designed to assess the efficacy of vericiguat in patients with HFpEF using the Kansas City Cardiomyopathy Questionnaire physical limitation score as a novel primary end point. This study will also extend the prior dosing experience with vericiguat in HF by studying the safety and efficacy of a 15 mg dose. Clinical Trial Registration URL: https://www.clinicaltrials.gov . Unique identifier: NCT03547583." @default.
• W2946323141 created "2019-05-29" @default.
• W2946323141 creator A5001281862 @default.
• W2946323141 creator A5006527198 @default.
• W2946323141 creator A5007409735 @default.
• W2946323141 creator A5009905903 @default.
• W2946323141 creator A5012849300 @default.
• W2946323141 creator A5015303092 @default.
• W2946323141 creator A5015595507 @default.
• W2946323141 creator A5017272571 @default.
• W2946323141 creator A5022314919 @default.
• W2946323141 creator A5023634772 @default.
• W2946323141 creator A5039800294 @default.
• W2946323141 creator A5048026987 @default.
• W2946323141 creator A5054830306 @default.
• W2946323141 creator A5067422552 @default.
• W2946323141 creator A5071968251 @default.
• W2946323141 creator A5074566771 @default.
• W2946323141 creator A5091026533 @default.
• W2946323141 date "2019-05-01" @default.
• W2946323141 modified "2023-10-05" @default.
• W2946323141 title "Rationale and Design of the VITALITY-HFpEF Trial" @default.
• W2946323141 cites W1494653833 @default.
• W2946323141 cites W1969639902 @default.
• W2946323141 cites W2009899857 @default.
• W2946323141 cites W2016471508 @default.
• W2946323141 cites W2033344309 @default.
• W2946323141 cites W2044591445 @default.
• W2946323141 cites W2057047340 @default.
• W2946323141 cites W2083650930 @default.
• W2946323141 cites W2090159456 @default.
• W2946323141 cites W2112155198 @default.
• W2946323141 cites W2115107692 @default.
• W2946323141 cites W2116403540 @default.
• W2946323141 cites W2129152730 @default.
• W2946323141 cites W2135885870 @default.
• W2946323141 cites W2165455162 @default.
• W2946323141 cites W2166504467 @default.
• W2946323141 cites W2192643629 @default.
• W2946323141 cites W2209002211 @default.
• W2946323141 cites W2213926659 @default.
• W2946323141 cites W2218389985 @default.
• W2946323141 cites W2261715823 @default.
• W2946323141 cites W2295209411 @default.
• W2946323141 cites W2303436247 @default.
• W2946323141 cites W2427094903 @default.
• W2946323141 cites W2474196988 @default.
• W2946323141 cites W2535547710 @default.
• W2946323141 cites W2547126679 @default.
• W2946323141 cites W2603535098 @default.
• W2946323141 cites W2621450152 @default.
• W2946323141 cites W2744220975 @default.
• W2946323141 cites W2761635900 @default.
• W2946323141 cites W2766542337 @default.
• W2946323141 cites W2892680253 @default.
• W2946323141 cites W2899687631 @default.
• W2946323141 doi "https://doi.org/10.1161/circheartfailure.119.005998" @default.
• W2946323141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31096775" @default.
• W2946323141 hasPublicationYear "2019" @default.
• W2946323141 type Work @default.
• W2946323141 sameAs 2946323141 @default.
• W2946323141 citedByCount "31" @default.
• W2946323141 countsByYear W29463231412019 @default.
• W2946323141 countsByYear W29463231412020 @default.
• W2946323141 countsByYear W29463231412021 @default.
• W2946323141 countsByYear W29463231412022 @default.
• W2946323141 countsByYear W29463231412023 @default.
• W2946323141 crossrefType "journal-article" @default.
• W2946323141 hasAuthorship W2946323141A5001281862 @default.
• W2946323141 hasAuthorship W2946323141A5006527198 @default.
• W2946323141 hasAuthorship W2946323141A5007409735 @default.
• W2946323141 hasAuthorship W2946323141A5009905903 @default.
• W2946323141 hasAuthorship W2946323141A5012849300 @default.
• W2946323141 hasAuthorship W2946323141A5015303092 @default.
• W2946323141 hasAuthorship W2946323141A5015595507 @default.
• W2946323141 hasAuthorship W2946323141A5017272571 @default.
• W2946323141 hasAuthorship W2946323141A5022314919 @default.
• W2946323141 hasAuthorship W2946323141A5023634772 @default.
• W2946323141 hasAuthorship W2946323141A5039800294 @default.
• W2946323141 hasAuthorship W2946323141A5048026987 @default.
• W2946323141 hasAuthorship W2946323141A5054830306 @default.
• W2946323141 hasAuthorship W2946323141A5067422552 @default.
• W2946323141 hasAuthorship W2946323141A5071968251 @default.
• W2946323141 hasAuthorship W2946323141A5074566771 @default.
• W2946323141 hasAuthorship W2946323141A5091026533 @default.
• W2946323141 hasBestOaLocation W29463231411 @default.
• W2946323141 hasConcept C126322002 @default.
• W2946323141 hasConcept C138885662 @default.
• W2946323141 hasConcept C142724271 @default.
• W2946323141 hasConcept C159110408 @default.
• W2946323141 hasConcept C164705383 @default.
• W2946323141 hasConcept C1862650 @default.
• W2946323141 hasConcept C203092338 @default.
• W2946323141 hasConcept C204787440 @default.
• W2946323141 hasConcept C27081682 @default.
• W2946323141 hasConcept C27206212 @default.
• W2946323141 hasConcept C2777099384 @default.
• W2946323141 hasConcept C2777321227 @default.
• W2946323141 hasConcept C2778198053 @default.
• W2946323141 hasConcept C2779829227 @default.

• next