FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946366970> ?p ?o ?g. }

• W2946366970 endingPage "1384" @default.
• W2946366970 startingPage "1372" @default.
• W2946366970 abstract "Purpose Obstructive sleep apnea (OSA) is linked to increased glaucoma risk in middle-aged and older adults. However, little is known about associations between OSA and glaucoma-related optic disc parameters in young adults. We explored associations between overnight polysomnography-derived measures of OSA and the optic disc in young adults. Design Cross-sectional cohort study. Participants Eight hundred forty-eight adults 19 to 22 years of age. Methods Participants underwent an ophthalmic examination that included OCT imaging of the optic disc and measurements of intraocular pressure, axial length, and refractive error. Participants then underwent an overnight polysomnography study that obtained measurements of apnea–hypopnea index (AHI), peripheral oxygen saturation level, and number of cortical arousals from sleep. Based on the AHI results, participants were grouped into no OSA (AHI < 5 events/hour), mild OSA (AHI ≥ 5 and <15 events/hour), moderate OSA (AHI ≥ 15 and <30 events/hour), or severe OSA (AHI ≥ 30 events/hour). Main Outcome Measures Neuroretinal rim area, horizontal and vertical widths, and peripapillary retinal nerve fiber layer (RNFL) thickness. Results The median AHI result across the study cohort was 2.2 events per hour (interquartile range, 1.0−4.4 events/hour). Based on the AHI results, 178 participants (21.0%) demonstrated OSA: 150 with mild OSA, 26 with moderate OSA, and 2 with severe OSA. In the unadjusted analyses, participants with OSA on average showed thinner peripapillary RNFL at the inferotemporal (P = 0.026) and superotemporal (P = 0.008) segments compared with those without OSA. Additionally, higher AHI results were associated with thinner RNFL superotemporally (P = 0.007). These findings remained significant after adjusting for gender, body mass index, ethnicity, and potential ocular confounders. There were no significant differences in optic disc measures between groups of OSA severity. Conclusions Obstructive sleep apnea may be associated with preclinical thinning of the peripapillary RNFL in young adults. This suggests that an increased glaucoma risk already may be present in individuals with OSA since young adulthood. Long-term follow-up of this cohort will allow further optic disc changes in relationship to polysomnography parameters to be documented and associations with future glaucoma diagnosis to be explored. Obstructive sleep apnea (OSA) is linked to increased glaucoma risk in middle-aged and older adults. However, little is known about associations between OSA and glaucoma-related optic disc parameters in young adults. We explored associations between overnight polysomnography-derived measures of OSA and the optic disc in young adults. Cross-sectional cohort study. Eight hundred forty-eight adults 19 to 22 years of age. Participants underwent an ophthalmic examination that included OCT imaging of the optic disc and measurements of intraocular pressure, axial length, and refractive error. Participants then underwent an overnight polysomnography study that obtained measurements of apnea–hypopnea index (AHI), peripheral oxygen saturation level, and number of cortical arousals from sleep. Based on the AHI results, participants were grouped into no OSA (AHI < 5 events/hour), mild OSA (AHI ≥ 5 and <15 events/hour), moderate OSA (AHI ≥ 15 and <30 events/hour), or severe OSA (AHI ≥ 30 events/hour). Neuroretinal rim area, horizontal and vertical widths, and peripapillary retinal nerve fiber layer (RNFL) thickness. The median AHI result across the study cohort was 2.2 events per hour (interquartile range, 1.0−4.4 events/hour). Based on the AHI results, 178 participants (21.0%) demonstrated OSA: 150 with mild OSA, 26 with moderate OSA, and 2 with severe OSA. In the unadjusted analyses, participants with OSA on average showed thinner peripapillary RNFL at the inferotemporal (P = 0.026) and superotemporal (P = 0.008) segments compared with those without OSA. Additionally, higher AHI results were associated with thinner RNFL superotemporally (P = 0.007). These findings remained significant after adjusting for gender, body mass index, ethnicity, and potential ocular confounders. There were no significant differences in optic disc measures between groups of OSA severity. Obstructive sleep apnea may be associated with preclinical thinning of the peripapillary RNFL in young adults. This suggests that an increased glaucoma risk already may be present in individuals with OSA since young adulthood. Long-term follow-up of this cohort will allow further optic disc changes in relationship to polysomnography parameters to be documented and associations with future glaucoma diagnosis to be explored." @default.
• W2946366970 created "2019-05-29" @default.
• W2946366970 creator A5002692582 @default.
• W2946366970 creator A5012820753 @default.
• W2946366970 creator A5041455706 @default.
• W2946366970 creator A5045241030 @default.
• W2946366970 creator A5051073262 @default.
• W2946366970 creator A5064816596 @default.
• W2946366970 creator A5069771802 @default.
• W2946366970 creator A5078843628 @default.
• W2946366970 date "2019-10-01" @default.
• W2946366970 modified "2023-10-18" @default.
• W2946366970 title "Associations between Optic Disc Measures and Obstructive Sleep Apnea in Young Adults" @default.
• W2946366970 cites W1545241942 @default.
• W2946366970 cites W1666151891 @default.
• W2946366970 cites W1896203604 @default.
• W2946366970 cites W1964203168 @default.
• W2946366970 cites W1967076538 @default.
• W2946366970 cites W1972925113 @default.
• W2946366970 cites W1975056245 @default.
• W2946366970 cites W1976632227 @default.
• W2946366970 cites W1983270038 @default.
• W2946366970 cites W1987947971 @default.
• W2946366970 cites W1989336853 @default.
• W2946366970 cites W1997072563 @default.
• W2946366970 cites W2001827423 @default.
• W2946366970 cites W2006685331 @default.
• W2946366970 cites W2008910832 @default.
• W2946366970 cites W2011114870 @default.
• W2946366970 cites W2024080336 @default.
• W2946366970 cites W2025308968 @default.
• W2946366970 cites W2028423075 @default.
• W2946366970 cites W2030023202 @default.
• W2946366970 cites W2032153593 @default.
• W2946366970 cites W2034556696 @default.
• W2946366970 cites W2037243569 @default.
• W2946366970 cites W2041953647 @default.
• W2946366970 cites W2047384783 @default.
• W2946366970 cites W2048964896 @default.
• W2946366970 cites W2049456217 @default.
• W2946366970 cites W2057884005 @default.
• W2946366970 cites W2059223618 @default.
• W2946366970 cites W2064694433 @default.
• W2946366970 cites W2067400934 @default.
• W2946366970 cites W2072730592 @default.
• W2946366970 cites W2089272122 @default.
• W2946366970 cites W2095688870 @default.
• W2946366970 cites W2103939721 @default.
• W2946366970 cites W2117075490 @default.
• W2946366970 cites W2117834225 @default.
• W2946366970 cites W2130677855 @default.
• W2946366970 cites W2137168556 @default.
• W2946366970 cites W2152079676 @default.
• W2946366970 cites W2160151168 @default.
• W2946366970 cites W2162922595 @default.
• W2946366970 cites W2267884561 @default.
• W2946366970 cites W2314331384 @default.
• W2946366970 cites W2323619192 @default.
• W2946366970 cites W2330551932 @default.
• W2946366970 cites W2335449614 @default.
• W2946366970 cites W2342001860 @default.
• W2946366970 cites W2404673173 @default.
• W2946366970 cites W2408549144 @default.
• W2946366970 doi "https://doi.org/10.1016/j.ophtha.2019.04.041" @default.
• W2946366970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31196726" @default.
• W2946366970 hasPublicationYear "2019" @default.
• W2946366970 type Work @default.
• W2946366970 sameAs 2946366970 @default.
• W2946366970 citedByCount "22" @default.
• W2946366970 countsByYear W29463669702020 @default.
• W2946366970 countsByYear W29463669702021 @default.
• W2946366970 countsByYear W29463669702022 @default.
• W2946366970 countsByYear W29463669702023 @default.
• W2946366970 crossrefType "journal-article" @default.
• W2946366970 hasAuthorship W2946366970A5002692582 @default.
• W2946366970 hasAuthorship W2946366970A5012820753 @default.
• W2946366970 hasAuthorship W2946366970A5041455706 @default.
• W2946366970 hasAuthorship W2946366970A5045241030 @default.
• W2946366970 hasAuthorship W2946366970A5051073262 @default.
• W2946366970 hasAuthorship W2946366970A5064816596 @default.
• W2946366970 hasAuthorship W2946366970A5069771802 @default.
• W2946366970 hasAuthorship W2946366970A5078843628 @default.
• W2946366970 hasConcept C118487528 @default.
• W2946366970 hasConcept C119060515 @default.
• W2946366970 hasConcept C126322002 @default.
• W2946366970 hasConcept C2776006263 @default.
• W2946366970 hasConcept C2777935920 @default.
• W2946366970 hasConcept C2778205975 @default.
• W2946366970 hasConcept C2778527774 @default.
• W2946366970 hasConcept C2780592520 @default.
• W2946366970 hasConcept C2781092963 @default.
• W2946366970 hasConcept C2781326671 @default.
• W2946366970 hasConcept C71924100 @default.
• W2946366970 hasConcept C72563966 @default.
• W2946366970 hasConceptScore W2946366970C118487528 @default.
• W2946366970 hasConceptScore W2946366970C119060515 @default.
• W2946366970 hasConceptScore W2946366970C126322002 @default.
• W2946366970 hasConceptScore W2946366970C2776006263 @default.

• next