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- W2946382924 endingPage "15" @default.
- W2946382924 startingPage "1" @default.
- W2946382924 abstract "To protect tissues and the organism from disease, potentially harmful cells are removed through programmed cell death processes, including apoptosis and necroptosis. These types of cell death are critically controlled by microRNAs (miRNAs). MiRNAs are short RNA molecules that target and inhibit expression of many cellular regulators, including those controlling programmed cell death via the intrinsic (Bcl-2 and Mcl-1), extrinsic (TRAIL and Fas), p53-and endoplasmic reticulum (ER) stress-induced apoptotic pathways, as well as the necroptosis cell death pathway. In this review, we discuss the current knowledge of apoptosis and necroptosis pathways and how these are impaired in cancer cells. We focus on how miRNAs disrupt apoptosis and necroptosis, thereby critically contributing to malignancy. Understanding which and how miRNAs and their targets affect cell death pathways could open up novel therapeutic opportunities for cancer patients. Indeed, restoration of pro-apoptotic tumor suppressor miRNAs (apoptomiRs) or inhibition of oncogenic miRNAs (oncomiRs) represent strategies that are currently being trialed or are already applied as miRNA-based cancer therapies. Therefore, better understanding the cancer type-specific expression of apoptomiRs and oncomiRs and their underlying mechanisms in cell death pathways will not only advance our knowledge, but also continue to provide new opportunities to treat cancer." @default.
- W2946382924 created "2019-05-29" @default.
- W2946382924 creator A5005400006 @default.
- W2946382924 creator A5008839777 @default.
- W2946382924 creator A5051948797 @default.
- W2946382924 creator A5063336810 @default.
- W2946382924 creator A5067735700 @default.
- W2946382924 creator A5069004573 @default.
- W2946382924 creator A5078320465 @default.
- W2946382924 date "2019-08-01" @default.
- W2946382924 modified "2023-10-14" @default.
- W2946382924 title "MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis" @default.
- W2946382924 cites W1486099519 @default.
- W2946382924 cites W1512072225 @default.
- W2946382924 cites W1515008413 @default.
- W2946382924 cites W1519652780 @default.
- W2946382924 cites W1537910049 @default.
- W2946382924 cites W1548403485 @default.
- W2946382924 cites W1563316806 @default.
- W2946382924 cites W1566057190 @default.
- W2946382924 cites W1607981272 @default.
- W2946382924 cites W1642763135 @default.
- W2946382924 cites W1781739971 @default.
- W2946382924 cites W1874540290 @default.
- W2946382924 cites W1896505782 @default.
- W2946382924 cites W1945652054 @default.
- W2946382924 cites W1966116761 @default.
- W2946382924 cites W1966163762 @default.
- W2946382924 cites W1966228034 @default.
- W2946382924 cites W1967894078 @default.
- W2946382924 cites W1967899052 @default.
- W2946382924 cites W1968328677 @default.
- W2946382924 cites W1970431885 @default.
- W2946382924 cites W1971873029 @default.
- W2946382924 cites W1972703850 @default.
- W2946382924 cites W1973363947 @default.
- W2946382924 cites W1973792489 @default.
- W2946382924 cites W1976161806 @default.
- W2946382924 cites W1977258127 @default.
- W2946382924 cites W1977376434 @default.
- W2946382924 cites W1977485776 @default.
- W2946382924 cites W1978826128 @default.
- W2946382924 cites W1979581732 @default.
- W2946382924 cites W1979784082 @default.
- W2946382924 cites W1983268059 @default.
- W2946382924 cites W1983657821 @default.
- W2946382924 cites W1983817294 @default.
- W2946382924 cites W1984659945 @default.
- W2946382924 cites W1984696190 @default.
- W2946382924 cites W1984789674 @default.
- W2946382924 cites W1985465738 @default.
- W2946382924 cites W1986247562 @default.
- W2946382924 cites W1986308149 @default.
- W2946382924 cites W1990261439 @default.
- W2946382924 cites W1990760558 @default.
- W2946382924 cites W1990992718 @default.
- W2946382924 cites W1991154912 @default.
- W2946382924 cites W1992089991 @default.
- W2946382924 cites W1992588518 @default.
- W2946382924 cites W1992616769 @default.
- W2946382924 cites W1993506009 @default.
- W2946382924 cites W1998332918 @default.
- W2946382924 cites W1998651094 @default.
- W2946382924 cites W1998733024 @default.
- W2946382924 cites W1999653222 @default.
- W2946382924 cites W2002424586 @default.
- W2946382924 cites W2002503549 @default.
- W2946382924 cites W2005109475 @default.
- W2946382924 cites W2006797972 @default.
- W2946382924 cites W2008757142 @default.
- W2946382924 cites W2009006896 @default.
- W2946382924 cites W2011180826 @default.
- W2946382924 cites W2012131946 @default.
- W2946382924 cites W2012774801 @default.
- W2946382924 cites W2012835470 @default.
- W2946382924 cites W2016548691 @default.
- W2946382924 cites W2018190474 @default.
- W2946382924 cites W2018195928 @default.
- W2946382924 cites W2018667424 @default.
- W2946382924 cites W2019199449 @default.
- W2946382924 cites W2022803736 @default.
- W2946382924 cites W2027020478 @default.
- W2946382924 cites W2027097496 @default.
- W2946382924 cites W2027389500 @default.
- W2946382924 cites W2027598316 @default.
- W2946382924 cites W2030613016 @default.
- W2946382924 cites W2030892254 @default.
- W2946382924 cites W2032767769 @default.
- W2946382924 cites W2035532825 @default.
- W2946382924 cites W2038444711 @default.
- W2946382924 cites W2038481055 @default.
- W2946382924 cites W2038540701 @default.
- W2946382924 cites W2043329242 @default.
- W2946382924 cites W2045070174 @default.
- W2946382924 cites W2046382304 @default.
- W2946382924 cites W2050299929 @default.
- W2946382924 cites W2051223311 @default.
- W2946382924 cites W2051584801 @default.