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- W2946392636 abstract "Abstract Folate metabolism in mammalian cells is essential for multiple vital processes, including purine and pyrimidine synthesis, histidine catabolism, methionine recycling, and utilization of formic acid. It remains unknown, however, whether these processes affect each other via folate metabolism or can function independently based on cellular needs. We addressed this question using a quantitative mathematical model of folate metabolism in rat liver cytoplasm. Variation in the rates of metabolic processes associated with folate metabolism (i.e., purine and pyrimidine synthesis, histidine catabolism, and influxes of formate and methionine) in the model revealed that folate metabolism is organized in a striking manner that enables activation or inhibition of each individual process independently of the metabolic fluxes in others. In mechanistic terms, this independence is based on the high activities of a group of enzymes involved in folate metabolism, which efficiently maintain close-to-equilibrium ratios between substrates and products of enzymatic reactions." @default.
- W2946392636 created "2019-05-29" @default.
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- W2946392636 date "2019-05-21" @default.
- W2946392636 modified "2023-09-23" @default.
- W2946392636 title "Rat liver folate metabolism can provide an independent functioning of associated metabolic pathways" @default.
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- W2946392636 cites W1604527618 @default.
- W2946392636 cites W1786956277 @default.
- W2946392636 cites W1893451189 @default.
- W2946392636 cites W1904394785 @default.
- W2946392636 cites W1946365220 @default.
- W2946392636 cites W1964388566 @default.
- W2946392636 cites W1965125658 @default.
- W2946392636 cites W1965615714 @default.
- W2946392636 cites W1968193225 @default.
- W2946392636 cites W1974161949 @default.
- W2946392636 cites W1974222213 @default.
- W2946392636 cites W1978998408 @default.
- W2946392636 cites W1983809640 @default.
- W2946392636 cites W1989356642 @default.
- W2946392636 cites W1993777583 @default.
- W2946392636 cites W1996451222 @default.
- W2946392636 cites W2001779904 @default.
- W2946392636 cites W2002699204 @default.
- W2946392636 cites W2004432428 @default.
- W2946392636 cites W2007827633 @default.
- W2946392636 cites W2011242734 @default.
- W2946392636 cites W2015943282 @default.
- W2946392636 cites W2018045523 @default.
- W2946392636 cites W2024070669 @default.
- W2946392636 cites W2027548964 @default.
- W2946392636 cites W2031883445 @default.
- W2946392636 cites W2035842529 @default.
- W2946392636 cites W2040847667 @default.
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- W2946392636 cites W2046015670 @default.
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- W2946392636 cites W2069168291 @default.
- W2946392636 cites W2073509725 @default.
- W2946392636 cites W2074385632 @default.
- W2946392636 cites W2080041409 @default.
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- W2946392636 cites W2080567081 @default.
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- W2946392636 cites W2087519699 @default.
- W2946392636 cites W2089841396 @default.
- W2946392636 cites W2095559553 @default.
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- W2946392636 cites W2120241648 @default.
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- W2946392636 cites W2168275452 @default.
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- W2946392636 cites W2285674353 @default.
- W2946392636 cites W2334889994 @default.
- W2946392636 cites W2539462439 @default.
- W2946392636 cites W2567118065 @default.
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- W2946392636 doi "https://doi.org/10.1038/s41598-019-44009-5" @default.
- W2946392636 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6529478" @default.
- W2946392636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31113966" @default.
- W2946392636 hasPublicationYear "2019" @default.
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