FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946393412> ?p ?o ?g. }

• W2946393412 endingPage "2148" @default.
• W2946393412 startingPage "2136" @default.
• W2946393412 abstract "Complex regional pain syndrome (CRPS) is a severely disabling disease characterized by pain, temperature changes, motor dysfunction, and edema that most often occurs as an atypical response to a minor surgery or fracture. Inflammation involving activation and recruitment of innate immune cells, including both peripheral and central myeloid cells (ie, macrophages and microglia, respectively), is a key feature of CRPS. However, the exact role and time course of these cellular processes relative to the known acute and chronic phases of the disease are not fully understood. Positron emission tomography (PET) of translocator protein-18 kDa (TSPO) is a method for noninvasively tracking these activated innate immune cells. Here, we reveal the temporal dynamics of peripheral and central inflammatory responses over 20 weeks in a tibial fracture/casting mouse model of CRPS through longitudinal TSPO-PET using [F]GE-180. Positron emission tomography tracer uptake quantification in the tibia revealed increased peripheral inflammation as early as 2 days after fracture and lasting 7 weeks. Centralized inflammation was detected in the spinal cord and brain of fractured mice at 7 and 21 days after injury. Spinal cord tissue immunofluorescent staining revealed TSPO expression in microglia (CD11b+) at 7 days but was restricted mainly to endothelial cells (PECAM1+) at baseline and 7 weeks. Our data suggest early and persistent peripheral myeloid cell activation and transient central microglial activation are limited to the acute phase of CRPS. Moreover, we show that TSPO-PET can be used to noninvasively monitor the spatiotemporal dynamics of myeloid cell activation in CRPS progression with potential to inform disease phase-specific therapeutics." @default.
• W2946393412 created "2019-05-29" @default.
• W2946393412 creator A5008400293 @default.
• W2946393412 creator A5013319200 @default.
• W2946393412 creator A5016807801 @default.
• W2946393412 creator A5020549705 @default.
• W2946393412 creator A5023658546 @default.
• W2946393412 creator A5032455262 @default.
• W2946393412 creator A5052853323 @default.
• W2946393412 creator A5056276855 @default.
• W2946393412 creator A5057745831 @default.
• W2946393412 creator A5087001955 @default.
• W2946393412 date "2019-05-08" @default.
• W2946393412 modified "2023-10-14" @default.
• W2946393412 title "Longitudinal translocator protein-18 kDa–positron emission tomography imaging of peripheral and central myeloid cells in a mouse model of complex regional pain syndrome" @default.
• W2946393412 cites W1542136448 @default.
• W2946393412 cites W1580597439 @default.
• W2946393412 cites W1652577435 @default.
• W2946393412 cites W1801036088 @default.
• W2946393412 cites W1964849585 @default.
• W2946393412 cites W1965276722 @default.
• W2946393412 cites W1971429641 @default.
• W2946393412 cites W1989201276 @default.
• W2946393412 cites W1989613983 @default.
• W2946393412 cites W2006161356 @default.
• W2946393412 cites W2011239875 @default.
• W2946393412 cites W2014801387 @default.
• W2946393412 cites W2022296972 @default.
• W2946393412 cites W2025208680 @default.
• W2946393412 cites W2034946478 @default.
• W2946393412 cites W2035605437 @default.
• W2946393412 cites W2037447829 @default.
• W2946393412 cites W2039116859 @default.
• W2946393412 cites W2049703902 @default.
• W2946393412 cites W2052418484 @default.
• W2946393412 cites W2054439940 @default.
• W2946393412 cites W2055129010 @default.
• W2946393412 cites W2077885131 @default.
• W2946393412 cites W2079224508 @default.
• W2946393412 cites W2088795854 @default.
• W2946393412 cites W2092595668 @default.
• W2946393412 cites W2095387649 @default.
• W2946393412 cites W2108978334 @default.
• W2946393412 cites W2112592817 @default.
• W2946393412 cites W2121100815 @default.
• W2946393412 cites W2123128921 @default.
• W2946393412 cites W2131386387 @default.
• W2946393412 cites W2135235221 @default.
• W2946393412 cites W2140441724 @default.
• W2946393412 cites W2161491363 @default.
• W2946393412 cites W2163345643 @default.
• W2946393412 cites W2172201406 @default.
• W2946393412 cites W2190814680 @default.
• W2946393412 cites W2253390436 @default.
• W2946393412 cites W2261364877 @default.
• W2946393412 cites W2275274326 @default.
• W2946393412 cites W2316047267 @default.
• W2946393412 cites W2491511888 @default.
• W2946393412 cites W2559679600 @default.
• W2946393412 cites W2570462964 @default.
• W2946393412 cites W2572710398 @default.
• W2946393412 cites W2734381060 @default.
• W2946393412 cites W2786438865 @default.
• W2946393412 cites W2791467130 @default.
• W2946393412 cites W2793012925 @default.
• W2946393412 cites W2801872281 @default.
• W2946393412 cites W2807775880 @default.
• W2946393412 cites W2886096965 @default.
• W2946393412 cites W2889952876 @default.
• W2946393412 cites W2890625851 @default.
• W2946393412 cites W2898067875 @default.
• W2946393412 cites W4238621170 @default.
• W2946393412 cites W657322800 @default.
• W2946393412 doi "https://doi.org/10.1097/j.pain.0000000000001607" @default.
• W2946393412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6527343" @default.
• W2946393412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31095093" @default.
• W2946393412 hasPublicationYear "2019" @default.
• W2946393412 type Work @default.
• W2946393412 sameAs 2946393412 @default.
• W2946393412 citedByCount "20" @default.
• W2946393412 countsByYear W29463934122020 @default.
• W2946393412 countsByYear W29463934122021 @default.
• W2946393412 countsByYear W29463934122022 @default.
• W2946393412 countsByYear W29463934122023 @default.
• W2946393412 crossrefType "journal-article" @default.
• W2946393412 hasAuthorship W2946393412A5008400293 @default.
• W2946393412 hasAuthorship W2946393412A5013319200 @default.
• W2946393412 hasAuthorship W2946393412A5016807801 @default.
• W2946393412 hasAuthorship W2946393412A5020549705 @default.
• W2946393412 hasAuthorship W2946393412A5023658546 @default.
• W2946393412 hasAuthorship W2946393412A5032455262 @default.
• W2946393412 hasAuthorship W2946393412A5052853323 @default.
• W2946393412 hasAuthorship W2946393412A5056276855 @default.
• W2946393412 hasAuthorship W2946393412A5057745831 @default.
• W2946393412 hasAuthorship W2946393412A5087001955 @default.
• W2946393412 hasBestOaLocation W29463934121 @default.
• W2946393412 hasConcept C136449434 @default.
• W2946393412 hasConcept C142724271 @default.

• next