FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946409717> ?p ?o ?g. }

• W2946409717 abstract "The Bioinformatics Resource Manager (BRM) is a web-based tool developed to facilitate identifier conversion and data integration for Homo sapiens (human), Mus musculus (mouse), Rattus norvegicus (rat), Danio rerio (zebrafish), and Macaca mulatta (macaque), as well as perform orthologous conversions among the supported species. In addition to providing a robust means of identifier conversion, BRM also incorporates a suite of microRNA (miRNA)-target databases upon which to query target genes or to perform reverse target lookups using gene identifiers. BRM has the capability to perform cross-species identifier lookups across common identifier types, directly integrate datasets across platform or species by performing identifier retrievals in the background, and retrieve miRNA targets from multiple databases simultaneously and integrate the resulting gene targets with experimental mRNA data. Here we use workflows provided in BRM to integrate RNA sequencing data across species to identify common biomarkers of exposure after treatment of human lung cells and zebrafish to benzo[a]pyrene (BAP). We further use the miRNA Target workflow to experimentally determine the role of miRNAs as regulators of BAP toxicity and identify the predicted functional consequences of miRNA-target regulation in our system. The output from BRM can easily and directly be uploaded to freely available visualization tools for further analysis. From these examples, we were able to identify an important role for several miRNAs as potential regulators of BAP toxicity in human lung cells associated with cell migration, cell communication, cell junction assembly and regulation of cell death. Overall, BRM provides bioinformatics tools to assist biologists having minimal programming skills with analysis and integration of high-content omics’ data from various transcriptomic and proteomic platforms. BRM workflows were developed in Java and other open-source technologies and are served publicly using Apache Tomcat at https://cbb.pnnl.gov/brm/ ." @default.
• W2946409717 created "2019-05-29" @default.
• W2946409717 creator A5010885167 @default.
• W2946409717 creator A5021107967 @default.
• W2946409717 creator A5029340820 @default.
• W2946409717 creator A5040788704 @default.
• W2946409717 creator A5047091057 @default.
• W2946409717 creator A5053476989 @default.
• W2946409717 creator A5072221598 @default.
• W2946409717 creator A5075469209 @default.
• W2946409717 creator A5077210745 @default.
• W2946409717 date "2019-05-17" @default.
• W2946409717 modified "2023-10-12" @default.
• W2946409717 title "Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration" @default.
• W2946409717 cites W1971204432 @default.
• W2946409717 cites W1976942746 @default.
• W2946409717 cites W2012555772 @default.
• W2946409717 cites W2042203018 @default.
• W2946409717 cites W2044832480 @default.
• W2946409717 cites W2070571588 @default.
• W2946409717 cites W2077327925 @default.
• W2946409717 cites W2083396498 @default.
• W2946409717 cites W2109488005 @default.
• W2946409717 cites W2151163584 @default.
• W2946409717 cites W2158217645 @default.
• W2946409717 cites W2159675211 @default.
• W2946409717 cites W2176909577 @default.
• W2946409717 cites W2335866275 @default.
• W2946409717 cites W2541513861 @default.
• W2946409717 cites W2604652930 @default.
• W2946409717 cites W2726115670 @default.
• W2946409717 cites W2766195206 @default.
• W2946409717 cites W2767546566 @default.
• W2946409717 cites W2768781242 @default.
• W2946409717 cites W2917207851 @default.
• W2946409717 cites W4233120011 @default.
• W2946409717 cites W4243601081 @default.
• W2946409717 doi "https://doi.org/10.1186/s12859-019-2805-6" @default.
• W2946409717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6525352" @default.
• W2946409717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31101000" @default.
• W2946409717 hasPublicationYear "2019" @default.
• W2946409717 type Work @default.
• W2946409717 sameAs 2946409717 @default.
• W2946409717 citedByCount "5" @default.
• W2946409717 countsByYear W29464097172019 @default.
• W2946409717 countsByYear W29464097172021 @default.
• W2946409717 crossrefType "journal-article" @default.
• W2946409717 hasAuthorship W2946409717A5010885167 @default.
• W2946409717 hasAuthorship W2946409717A5021107967 @default.
• W2946409717 hasAuthorship W2946409717A5029340820 @default.
• W2946409717 hasAuthorship W2946409717A5040788704 @default.
• W2946409717 hasAuthorship W2946409717A5047091057 @default.
• W2946409717 hasAuthorship W2946409717A5053476989 @default.
• W2946409717 hasAuthorship W2946409717A5072221598 @default.
• W2946409717 hasAuthorship W2946409717A5075469209 @default.
• W2946409717 hasAuthorship W2946409717A5077210745 @default.
• W2946409717 hasBestOaLocation W29464097171 @default.
• W2946409717 hasConcept C104317684 @default.
• W2946409717 hasConcept C136764020 @default.
• W2946409717 hasConcept C145059251 @default.
• W2946409717 hasConcept C152662350 @default.
• W2946409717 hasConcept C206345919 @default.
• W2946409717 hasConcept C2522767166 @default.
• W2946409717 hasConcept C31258907 @default.
• W2946409717 hasConcept C41008148 @default.
• W2946409717 hasConcept C54355233 @default.
• W2946409717 hasConcept C60644358 @default.
• W2946409717 hasConcept C70721500 @default.
• W2946409717 hasConcept C72634772 @default.
• W2946409717 hasConcept C77088390 @default.
• W2946409717 hasConcept C86803240 @default.
• W2946409717 hasConceptScore W2946409717C104317684 @default.
• W2946409717 hasConceptScore W2946409717C136764020 @default.
• W2946409717 hasConceptScore W2946409717C145059251 @default.
• W2946409717 hasConceptScore W2946409717C152662350 @default.
• W2946409717 hasConceptScore W2946409717C206345919 @default.
• W2946409717 hasConceptScore W2946409717C2522767166 @default.
• W2946409717 hasConceptScore W2946409717C31258907 @default.
• W2946409717 hasConceptScore W2946409717C41008148 @default.
• W2946409717 hasConceptScore W2946409717C54355233 @default.
• W2946409717 hasConceptScore W2946409717C60644358 @default.
• W2946409717 hasConceptScore W2946409717C70721500 @default.
• W2946409717 hasConceptScore W2946409717C72634772 @default.
• W2946409717 hasConceptScore W2946409717C77088390 @default.
• W2946409717 hasConceptScore W2946409717C86803240 @default.
• W2946409717 hasFunder F4320337361 @default.
• W2946409717 hasIssue "1" @default.
• W2946409717 hasLocation W29464097171 @default.
• W2946409717 hasLocation W29464097172 @default.
• W2946409717 hasLocation W29464097173 @default.
• W2946409717 hasOpenAccess W2946409717 @default.
• W2946409717 hasPrimaryLocation W29464097171 @default.
• W2946409717 hasRelatedWork W1989319466 @default.
• W2946409717 hasRelatedWork W2123231955 @default.
• W2946409717 hasRelatedWork W2142532074 @default.
• W2946409717 hasRelatedWork W2142674442 @default.
• W2946409717 hasRelatedWork W2205871895 @default.
• W2946409717 hasRelatedWork W2485523520 @default.
• W2946409717 hasRelatedWork W2561772691 @default.
• W2946409717 hasRelatedWork W2744636379 @default.

• next