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- W2946410887 abstract "The virulence strategy of pathogenic Yersinia spp. involves cell-invasive as well as phagocytosis-preventing tactics to enable efficient colonisation of the host organism. Enteropathogenic yersiniae display an invasive phenotype in early infection stages, which facilitates penetration of the intestinal mucosa. Here we show that invasion of epithelial cells by Yersinia enterocolitica is followed by intracellular survival and multiplication of a subset of ingested bacteria. The replicating bacteria were enclosed in vacuoles with autophagy-related characteristics, showing phagophore formation, xenophagy, and recruitment of cytoplasmic autophagosomes to the bacteria-containing compartments. The subsequent fusion of these vacuoles with lysosomes and concomitant vesicle acidification were actively blocked by Yersinia. This resulted in increased intracellular proliferation and detectable egress of yersiniae from infected cells. Notably, deficiency of the core autophagy machinery component FIP200 impaired the development of autophagic features at Yersinia-containing vacuoles as well as intracellular replication and release of bacteria to the extracellular environment. These results suggest that Y. enterocolitica may take advantage of the macroautophagy pathway in epithelial cells to create an autophagosomal niche that supports intracellular bacterial survival, replication, and, eventually, spread of the bacteria from infected cells." @default.
- W2946410887 created "2019-05-29" @default.
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- W2946410887 date "2019-06-02" @default.
- W2946410887 modified "2023-10-17" @default.
- W2946410887 title "Activation of the macroautophagy pathway byYersinia enterocoliticapromotes intracellular multiplication and egress of yersiniae from epithelial cells" @default.
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- W2946410887 cites W1963810218 @default.
- W2946410887 cites W1972517547 @default.
- W2946410887 cites W1982934728 @default.
- W2946410887 cites W1983584781 @default.
- W2946410887 cites W1989652111 @default.
- W2946410887 cites W1992659717 @default.
- W2946410887 cites W1995785411 @default.
- W2946410887 cites W1998855132 @default.
- W2946410887 cites W1998996946 @default.
- W2946410887 cites W2004434588 @default.
- W2946410887 cites W2012645071 @default.
- W2946410887 cites W2032776183 @default.
- W2946410887 cites W2033290325 @default.
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- W2946410887 cites W2079046408 @default.
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- W2946410887 cites W2084693908 @default.
- W2946410887 cites W2088140877 @default.
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- W2946410887 cites W2148143293 @default.
- W2946410887 cites W2166614340 @default.
- W2946410887 cites W2171718924 @default.
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- W2946410887 doi "https://doi.org/10.1111/cmi.13046" @default.
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