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• W2946419020 abstract "Modular domains of long non-coding RNAs can serve as scaffolds to bring distant regions of the linear genome into spatial proximity. Here, we present HiChIRP, a method leveraging bio-orthogonal chemistry and optimized chromosome conformation capture conditions, which enables interrogation of chromatin architecture focused around a specific RNA of interest down to approximately ten copies per cell. HiChIRP of three nuclear RNAs reveals insights into promoter interactions (7SK), telomere biology (telomerase RNA component) and inflammatory gene regulation (lincRNA-EPS)." @default.
• W2946419020 created "2019-05-29" @default.
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• W2946419020 date "2019-05-27" @default.
• W2946419020 modified "2023-10-18" @default.
• W2946419020 title "HiChIRP reveals RNA-associated chromosome conformation" @default.
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• W2946419020 doi "https://doi.org/10.1038/s41592-019-0407-x" @default.
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