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• W2946426718 abstract "A novel series of indazole/indole derivatives were discovered as glucagon receptor (GCGR) antagonists through scaffold hopping based on two literature leads: MK-0893 and LY-2409021. Further structure-activity relationship (SAR) exploration and optimization led to the discovery of multiple potent GCGR antagonists with excellent pharmacokinetic properties in mice and rats, including low systemic clearance, long elimination half-life, and good oral bioavailability. These potent GCGR antagonists could be used for potential treatment of type II diabetes." @default.
• W2946426718 created "2019-05-29" @default.
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• W2946426718 date "2019-08-01" @default.
• W2946426718 modified "2023-10-16" @default.
• W2946426718 title "Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists" @default.
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• W2946426718 doi "https://doi.org/10.1016/j.bmcl.2019.05.036" @default.
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