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- W2946427233 abstract "Cyclooxygenase 2 (COX-2) is an inducible rate-limiting enzyme for prostanoid production. Because COX-2 represents one of the inducible genes in mouse mesenchymal stem cells upon differentiation into Leydig cells, we investigated COX-2 expression and production of prostaglandin (PG) in Leydig cells. Although COX-2 was undetectable in mouse testis, it was transiently induced in Leydig cells by human chorionic gonadotropin (hCG) administration. Consistent with the finding that Leydig cells expressed aldo-keto reductase 1B7 (PGF synthase) and PGE synthase 2, induction of COX-2 by hCG caused a marked increase in testicular PGF 2α and PGE 2 levels. Using mouse Leydig cell tumor-derived MA-10 cells as a model, it was indicated by reporter assays and electron mobility shift assays that transcription of the COX-2 gene was activated by CCAAT/enhancer-binding protein β (C/EBPβ) with cAMP-stimulation. C/EBPβ expression was induced by cAMP-stimulation, whereas expression of C/EBP homolog protein (CHOP) was robustly downregulated. Transfection of CHOP expression plasmid inhibited cAMP-induced COX-2 promoter activity. In addition, CHOP reduced constitutive COX-2 expression in other mouse Leydig cell tumor-derived TM3 cells. These results indicate that COX-2 is induced in Leydig cells by activation of C/EBPβ via reduction of CHOP expression upon gonadotropin-stimulation to produce PGF 2α and PGE 2 ." @default.
- W2946427233 created "2019-05-29" @default.
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- W2946427233 date "2019-05-13" @default.
- W2946427233 modified "2023-10-16" @default.
- W2946427233 title "Cyclooxygenase‐2 is acutely induced by CCAAT/enhancer‐binding protein β to produce prostaglandin E <sub>2</sub> and F <sub>2α</sub> following gonadotropin stimulation in Leydig cells" @default.
- W2946427233 cites W161652132 @default.
- W2946427233 cites W1939477527 @default.
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- W2946427233 cites W1974191631 @default.
- W2946427233 cites W1977873240 @default.
- W2946427233 cites W1983683479 @default.
- W2946427233 cites W1984887453 @default.
- W2946427233 cites W1990550829 @default.
- W2946427233 cites W1997377831 @default.
- W2946427233 cites W1998454004 @default.
- W2946427233 cites W2000038696 @default.
- W2946427233 cites W2001300225 @default.
- W2946427233 cites W2005977520 @default.
- W2946427233 cites W2008360112 @default.
- W2946427233 cites W2025511820 @default.
- W2946427233 cites W2031447271 @default.
- W2946427233 cites W2032270986 @default.
- W2946427233 cites W2032354110 @default.
- W2946427233 cites W2032547658 @default.
- W2946427233 cites W2035757406 @default.
- W2946427233 cites W2035916213 @default.
- W2946427233 cites W2038269021 @default.
- W2946427233 cites W2039590485 @default.
- W2946427233 cites W2041114367 @default.
- W2946427233 cites W2041461212 @default.
- W2946427233 cites W2041655797 @default.
- W2946427233 cites W2045114035 @default.
- W2946427233 cites W2049730346 @default.
- W2946427233 cites W2054033355 @default.
- W2946427233 cites W2055627135 @default.
- W2946427233 cites W2056927101 @default.
- W2946427233 cites W2057247307 @default.
- W2946427233 cites W2072157072 @default.
- W2946427233 cites W2072270890 @default.
- W2946427233 cites W2078503449 @default.
- W2946427233 cites W2083964238 @default.
- W2946427233 cites W2084409460 @default.
- W2946427233 cites W2085052924 @default.
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- W2946427233 cites W2103483160 @default.
- W2946427233 cites W2110023545 @default.
- W2946427233 cites W2117881262 @default.
- W2946427233 cites W2121612337 @default.
- W2946427233 cites W2121960517 @default.
- W2946427233 cites W2125714827 @default.
- W2946427233 cites W2126853519 @default.
- W2946427233 cites W2130814155 @default.
- W2946427233 cites W2131484746 @default.
- W2946427233 cites W2134386457 @default.
- W2946427233 cites W2136239478 @default.
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- W2946427233 cites W2137702233 @default.
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- W2946427233 cites W2402118151 @default.
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- W2946427233 doi "https://doi.org/10.1002/mrd.23163" @default.
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