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- W2946444890 abstract "Platelet adhesion as a measurement of platelet function was performed in 50 normal and 100 abnormal patients. A Bowie-type glass bead column and a constant perfusion technique was used. Template bleeding times (TBT) and platelet aggregation was also obtained in abnormals. The abnormal population consisted of patients referred with a disorder of hemostasis thought to be due to platelet dysfunction. Results on the normal population revealed “normal” adhesion to be defined as 89% to 100% retention, with an average of 94.8 ± 2.7% and a standard error of 0.41 (entire range for normals = 88% - 98%). In all 100 abnormals sent for evaluation, platelet adhesion correlated very well with aggregation, and more importantly, with clinical bleeding. In several cases abnormal adhesion and normal aggregation was seen; these 6 patients were classical von Willebrands, In 4 patients normal adhesion and abnormal aggregation was noted; this was due to aspirin use. Four patients had borderline adhesion and aggregation, and in all others the pattern was either normal adhesion and aggregation or abnormal adhesion and aggregation. In the vast majority of abnormals there was absolute correlation between adhesion and the TBT; in those 6 patients where correlation was lacking, the TBT was normal and adhesion was abnormal. These 6 patients had a malignant paraprotein disorder with paraprotein-induced platelet dysfunction. The results of this study suggest platelet adhesion, when done in a standardized fashion, to be a highly reproducible modality to assess platelet function. Using this methodology the normal range is narrow and excellent correlation is noted between abnormal adhesion, abnormal aggregation and clinical bleedability." @default.
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- W2946444890 date "1977-01-01" @default.
- W2946444890 modified "2023-09-23" @default.
- W2946444890 title "Clinical Use of Platelet Adhesion" @default.
- W2946444890 doi "https://doi.org/10.1055/s-0039-1680734" @default.
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