FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946475978> ?p ?o ?g. }

• W2946475978 endingPage "3293" @default.
• W2946475978 startingPage "3284" @default.
• W2946475978 abstract "Background: Recent studies demonstrated a 5% increase in cartilage repair procedures annually in the United States. There is currently no consensus regarding a superior technique, nor has there been a comprehensive evaluation of postoperative clinical outcomes with respect to a minimal clinically important difference (MCID). Purpose: To determine the proportion of available cartilage repair studies that meet or exceed MCID values for clinical outcomes improvement over short-, mid-, and long-term follow-up. Study Design: Systematic review and meta-analysis. Methods: A systematic review was performed via the Medline, Scopus, and Cochrane Library databases. Available studies were included that investigated clinical outcomes for microfracture (MFX), osteoarticular transfer system (OATS), osteochondral allograft transplantation, and autologous chondrocyte implantation/matrix-induced autologous chondrocyte implantation (ACI/MACI) for the treatment of symptomatic knee chondral defects. Cohorts were combined on the basis of surgical intervention by performing a meta-analysis that utilized inverse-variance weighting in a DerSimonian-Laird random effects model. Weighted mean improvements in International Knee Documentation Committee (IKDC), Lysholm, and visual analog scale for pain (VAS pain) scores were calculated from preoperative to short- (1-4 years), mid- (5-9 years), and long-term (≥10 years) postoperative follow-up. Mean values were compared with established MCID values per 2-tailed 1-sample Student t tests. Results: A total of 89 studies with 3894 unique patients were analyzed after full-text review. MFX met MCID values for all outcome scores at short- and midterm follow-up with the exception of VAS pain in the midterm. OATS met MCID values for all outcome scores at all available time points; however, long-term data were not available for VAS pain. Osteochondral allograft transplantation met MCID values for IKDC at short- and midterm follow-up and for Lysholm at short-term follow-up, although data were not available for other time points or for VAS pain. ACI/MACI met MCID values for all outcome scores (IKDC, Lysholm, and VAS pain) at all time points. Conclusion: In the age of informed consent, it is important to critically evaluate the clinical outcomes and durability of cartilage surgery with respect to well-established standards of clinical improvement. MFX failed to maintain VAS pain improvements above MCID thresholds with follow-up from 5 to 9 years. All cartilage repair procedures met MCID values at short- and midterm follow-up for IKDC and Lysholm scores; ACI/MACI and OATS additionally met MCID values in the long term, demonstrating extended maintenance of clinical benefits for patients undergoing these surgical interventions as compared with MFX." @default.
• W2946475978 created "2019-05-29" @default.
• W2946475978 creator A5010117815 @default.
• W2946475978 creator A5030416989 @default.
• W2946475978 creator A5046241819 @default.
• W2946475978 creator A5058108856 @default.
• W2946475978 creator A5068833670 @default.
• W2946475978 date "2019-05-13" @default.
• W2946475978 modified "2023-10-16" @default.
• W2946475978 title "Comparative Effectiveness of Cartilage Repair With Respect to the Minimal Clinically Important Difference" @default.
• W2946475978 cites W13558046 @default.
• W2946475978 cites W1549122075 @default.
• W2946475978 cites W1862462535 @default.
• W2946475978 cites W1942341118 @default.
• W2946475978 cites W1965522233 @default.
• W2946475978 cites W1965824173 @default.
• W2946475978 cites W1970380268 @default.
• W2946475978 cites W1975556707 @default.
• W2946475978 cites W1977341248 @default.
• W2946475978 cites W1978488869 @default.
• W2946475978 cites W1984480132 @default.
• W2946475978 cites W1985372153 @default.
• W2946475978 cites W1988169311 @default.
• W2946475978 cites W1988858686 @default.
• W2946475978 cites W1989325993 @default.
• W2946475978 cites W1990714143 @default.
• W2946475978 cites W1992912603 @default.
• W2946475978 cites W1994938385 @default.
• W2946475978 cites W1996999230 @default.
• W2946475978 cites W1999822828 @default.
• W2946475978 cites W2000879488 @default.
• W2946475978 cites W2005615031 @default.
• W2946475978 cites W2006673384 @default.
• W2946475978 cites W2009786866 @default.
• W2946475978 cites W2010283595 @default.
• W2946475978 cites W2013970299 @default.
• W2946475978 cites W2016057024 @default.
• W2946475978 cites W2016695540 @default.
• W2946475978 cites W2017083443 @default.
• W2946475978 cites W2017677493 @default.
• W2946475978 cites W2022804076 @default.
• W2946475978 cites W2027245388 @default.
• W2946475978 cites W2032217887 @default.
• W2946475978 cites W2036963208 @default.
• W2946475978 cites W2048604604 @default.
• W2946475978 cites W2049293593 @default.
• W2946475978 cites W2052652048 @default.
• W2946475978 cites W2054534259 @default.
• W2946475978 cites W2055110769 @default.
• W2946475978 cites W2058235067 @default.
• W2946475978 cites W2058450683 @default.
• W2946475978 cites W2058782007 @default.
• W2946475978 cites W2059977291 @default.
• W2946475978 cites W2061073787 @default.
• W2946475978 cites W2065986583 @default.
• W2946475978 cites W2066080075 @default.
• W2946475978 cites W2066270834 @default.
• W2946475978 cites W2068089560 @default.
• W2946475978 cites W2073859533 @default.
• W2946475978 cites W2074031425 @default.
• W2946475978 cites W2077834407 @default.
• W2946475978 cites W2080948384 @default.
• W2946475978 cites W2081100709 @default.
• W2946475978 cites W2081503605 @default.
• W2946475978 cites W2082227862 @default.
• W2946475978 cites W2086072387 @default.
• W2946475978 cites W2086249560 @default.
• W2946475978 cites W2090662913 @default.
• W2946475978 cites W2090977911 @default.
• W2946475978 cites W2104448425 @default.
• W2946475978 cites W2105276893 @default.
• W2946475978 cites W2105862213 @default.
• W2946475978 cites W2106887225 @default.
• W2946475978 cites W2107933482 @default.
• W2946475978 cites W2107982572 @default.
• W2946475978 cites W2108644032 @default.
• W2946475978 cites W2111661585 @default.
• W2946475978 cites W2113377069 @default.
• W2946475978 cites W2113434515 @default.
• W2946475978 cites W2113457553 @default.
• W2946475978 cites W2118626261 @default.
• W2946475978 cites W2120787455 @default.
• W2946475978 cites W2123839363 @default.
• W2946475978 cites W2127324240 @default.
• W2946475978 cites W2127616408 @default.
• W2946475978 cites W2129254602 @default.
• W2946475978 cites W2129573593 @default.
• W2946475978 cites W2130778418 @default.
• W2946475978 cites W2136939630 @default.
• W2946475978 cites W2139861324 @default.
• W2946475978 cites W2143735635 @default.
• W2946475978 cites W2145932168 @default.
• W2946475978 cites W2155829214 @default.
• W2946475978 cites W2157546127 @default.
• W2946475978 cites W2158143099 @default.
• W2946475978 cites W2163629389 @default.
• W2946475978 cites W2170057345 @default.
• W2946475978 cites W2170402701 @default.

• next