Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946502805> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2946502805 endingPage "24" @default.
- W2946502805 startingPage "23" @default.
- W2946502805 abstract "Introduction: Transmissible mink encephalopathy (TME) is a fatal neurologic prion disease of farmed mink. Epidemiologic and experimental evidence following a Wisconsin outbreak in 1985 has linked TME to low-type bovine spongiform encephalopathy (BSE-L). Evidence suggests that farmed mink were likely exposed through feeding of BSE-L infected downer cattle. The interspecies transmission of TME to cattle has been documented. Recently, we demonstrated the susceptibility of sheep to cattle passaged TME by intracranial inoculation. The aim of the present study was to compare ovine passaged cattle TME to other prion diseases of food-producing animals. Using a bovine transgenic mouse model, we compared the disease phenotype of sheep TME to BSE-C and BSE-L.Materials and Methods: Separate inoculants of sheep passaged TME were derived from animals with the VRQ/VRQ (VV136) and ARQ/VRQ (AV136) prion protein genotype. Transgenic bovinized mice (TgBovXV) were intracranially inoculated with 20 µl of 1% w/v brain homogenate. The disease phenotypes were characterized by comparing the attack rates, incubation periods, and vacuolation profiles in TgBovXV mice.Results: The attack rate for BSE-C (13/13), BSE-L (18/18), and TMEVV (21/21) was 100%; whereas, the TMEAV group (15/19) had an incomplete attack rate. The average incubation periods were 299, 280, 310, and 541 days, respectively. The vacuolation profiles of BSE-L and TMEVV were most similar with mild differences observed in the thalamus and medulla. Vacuolation profiles from the BSE-C and TMEAV experimental groups were different than TMEVV and BSE-L.Conclusion: Overall the phenotype of disease in TME inoculated transgenic mice was dependent on the sheep donor genotype (VV vs AV). The results of the present study indicate that TME isolated from VRQ/VRQ sheep is similar to BSE-L with regards to incubation period, attack rate, and vacuolation profile. Our findings are in agreement with previous research that found phenotypic similarities between BSE-L and cattle passaged TME in an ovine transgenic rodent model. In this study, the similarities between ovine TME and BSE-L are maintained after multiple interspecies passages." @default.
- W2946502805 created "2019-05-29" @default.
- W2946502805 creator A5014632485 @default.
- W2946502805 creator A5032855931 @default.
- W2946502805 creator A5033162218 @default.
- W2946502805 creator A5042902863 @default.
- W2946502805 creator A5061881805 @default.
- W2946502805 creator A5078928217 @default.
- W2946502805 date "2019-05-22" @default.
- W2946502805 modified "2023-09-23" @default.
- W2946502805 title "The agent of transmissible mink encephalopathy passaged in sheep is similar to BSE-L" @default.
- W2946502805 hasPublicationYear "2019" @default.
- W2946502805 type Work @default.
- W2946502805 sameAs 2946502805 @default.
- W2946502805 citedByCount "0" @default.
- W2946502805 crossrefType "journal-article" @default.
- W2946502805 hasAuthorship W2946502805A5014632485 @default.
- W2946502805 hasAuthorship W2946502805A5032855931 @default.
- W2946502805 hasAuthorship W2946502805A5033162218 @default.
- W2946502805 hasAuthorship W2946502805A5042902863 @default.
- W2946502805 hasAuthorship W2946502805A5061881805 @default.
- W2946502805 hasAuthorship W2946502805A5078928217 @default.
- W2946502805 hasBestOaLocation W29465028051 @default.
- W2946502805 hasConcept C104317684 @default.
- W2946502805 hasConcept C116675565 @default.
- W2946502805 hasConcept C126322002 @default.
- W2946502805 hasConcept C135763542 @default.
- W2946502805 hasConcept C142724271 @default.
- W2946502805 hasConcept C143701427 @default.
- W2946502805 hasConcept C159047783 @default.
- W2946502805 hasConcept C180032290 @default.
- W2946502805 hasConcept C18903297 @default.
- W2946502805 hasConcept C203014093 @default.
- W2946502805 hasConcept C25642318 @default.
- W2946502805 hasConcept C2776735649 @default.
- W2946502805 hasConcept C2776797465 @default.
- W2946502805 hasConcept C2778621155 @default.
- W2946502805 hasConcept C2779134260 @default.
- W2946502805 hasConcept C2779192065 @default.
- W2946502805 hasConcept C2780754187 @default.
- W2946502805 hasConcept C2781131914 @default.
- W2946502805 hasConcept C3019804061 @default.
- W2946502805 hasConcept C54355233 @default.
- W2946502805 hasConcept C55493867 @default.
- W2946502805 hasConcept C71924100 @default.
- W2946502805 hasConcept C86803240 @default.
- W2946502805 hasConceptScore W2946502805C104317684 @default.
- W2946502805 hasConceptScore W2946502805C116675565 @default.
- W2946502805 hasConceptScore W2946502805C126322002 @default.
- W2946502805 hasConceptScore W2946502805C135763542 @default.
- W2946502805 hasConceptScore W2946502805C142724271 @default.
- W2946502805 hasConceptScore W2946502805C143701427 @default.
- W2946502805 hasConceptScore W2946502805C159047783 @default.
- W2946502805 hasConceptScore W2946502805C180032290 @default.
- W2946502805 hasConceptScore W2946502805C18903297 @default.
- W2946502805 hasConceptScore W2946502805C203014093 @default.
- W2946502805 hasConceptScore W2946502805C25642318 @default.
- W2946502805 hasConceptScore W2946502805C2776735649 @default.
- W2946502805 hasConceptScore W2946502805C2776797465 @default.
- W2946502805 hasConceptScore W2946502805C2778621155 @default.
- W2946502805 hasConceptScore W2946502805C2779134260 @default.
- W2946502805 hasConceptScore W2946502805C2779192065 @default.
- W2946502805 hasConceptScore W2946502805C2780754187 @default.
- W2946502805 hasConceptScore W2946502805C2781131914 @default.
- W2946502805 hasConceptScore W2946502805C3019804061 @default.
- W2946502805 hasConceptScore W2946502805C54355233 @default.
- W2946502805 hasConceptScore W2946502805C55493867 @default.
- W2946502805 hasConceptScore W2946502805C71924100 @default.
- W2946502805 hasConceptScore W2946502805C86803240 @default.
- W2946502805 hasLocation W29465028051 @default.
- W2946502805 hasLocation W29465028052 @default.
- W2946502805 hasOpenAccess W2946502805 @default.
- W2946502805 hasPrimaryLocation W29465028051 @default.
- W2946502805 hasRelatedWork W171684956 @default.
- W2946502805 hasRelatedWork W1847539946 @default.
- W2946502805 hasRelatedWork W186505491 @default.
- W2946502805 hasRelatedWork W1964712424 @default.
- W2946502805 hasRelatedWork W1976611065 @default.
- W2946502805 hasRelatedWork W1986024784 @default.
- W2946502805 hasRelatedWork W2016656104 @default.
- W2946502805 hasRelatedWork W2047928957 @default.
- W2946502805 hasRelatedWork W2052317760 @default.
- W2946502805 hasRelatedWork W2069487106 @default.
- W2946502805 hasRelatedWork W2081013825 @default.
- W2946502805 hasRelatedWork W2145153065 @default.
- W2946502805 hasRelatedWork W2147962297 @default.
- W2946502805 hasRelatedWork W2149924224 @default.
- W2946502805 hasRelatedWork W2150151638 @default.
- W2946502805 hasRelatedWork W2261386015 @default.
- W2946502805 hasRelatedWork W2294830053 @default.
- W2946502805 hasRelatedWork W2412654484 @default.
- W2946502805 hasRelatedWork W3037165225 @default.
- W2946502805 hasRelatedWork W2188831089 @default.
- W2946502805 isParatext "false" @default.
- W2946502805 isRetracted "false" @default.
- W2946502805 magId "2946502805" @default.
- W2946502805 workType "article" @default.