FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946508770> ?p ?o ?g. }

• W2946508770 endingPage "153303381984663" @default.
• W2946508770 startingPage "153303381984663" @default.
• W2946508770 abstract "α-Fetoprotein is commonly used in the diagnosis of hepatocellular carcinoma. However, the diagnostic significance of α-fetoprotein has been questioned because a number of patients with hepatocellular carcinoma are α-fetoprotein negative. It is therefore necessary to develop novel noninvasive techniques for the early diagnosis of hepatocellular carcinoma, particularly when α-fetoprotein level is low or negative. The current study aimed to evaluate the diagnostic efficiency of hematological parameters to determine which can act as surrogate markers in α-fetoprotein–negative hepatocellular carcinoma. Therefore, a retrospective study was conducted on a training set recruited from Zhongnan Hospital of Wuhan University—including 171 α-fetoprotein–negative patients with hepatocellular carcinoma and 102 healthy individuals. The results show that mean values of mean platelet volume, red blood cell distribution width, mean platelet volume–PC ratio, neutrophils–lymphocytes ratio, and platelet count–lymphocytes ratio were significantly higher in patients with hepatocellular carcinoma in comparison to the healthy individuals. Most of these parameters showed moderate area under the curve in α-fetoprotein–negative patients with hepatocellular carcinoma, but their sensitivities or specificities were not satisfactory enough. So, we built a logistic regression model combining multiple hematological parameters. This model presented better diagnostic efficiency with area under the curve of 0.922, sensitivity of 83.0%, and specificity of 93.1%. In addition, the 4 validation sets from different hospitals were used to validate the model. They all showed good area under the curve with satisfactory sensitivities or specificities. These data indicate that the logistic regression model combining multiple hematological parameters has better diagnostic efficiency, and they might be helpful for the early diagnosis for α-fetoprotein–negative hepatocellular carcinoma." @default.
• W2946508770 created "2019-05-29" @default.
• W2946508770 creator A5009012652 @default.
• W2946508770 creator A5011671476 @default.
• W2946508770 creator A5022499603 @default.
• W2946508770 creator A5022903030 @default.
• W2946508770 creator A5044521267 @default.
• W2946508770 creator A5048378293 @default.
• W2946508770 creator A5058522873 @default.
• W2946508770 creator A5071701211 @default.
• W2946508770 creator A5080951657 @default.
• W2946508770 date "2019-01-01" @default.
• W2946508770 modified "2023-10-18" @default.
• W2946508770 title "A Logistic Regression Model for Noninvasive Prediction of AFP-Negative Hepatocellular Carcinoma" @default.
• W2946508770 cites W1566879104 @default.
• W2946508770 cites W185221403 @default.
• W2946508770 cites W1942321192 @default.
• W2946508770 cites W1966795284 @default.
• W2946508770 cites W1971189741 @default.
• W2946508770 cites W1988511730 @default.
• W2946508770 cites W2000881039 @default.
• W2946508770 cites W2001137775 @default.
• W2946508770 cites W2022347692 @default.
• W2946508770 cites W2024139196 @default.
• W2946508770 cites W2024671872 @default.
• W2946508770 cites W2048454917 @default.
• W2946508770 cites W2057494957 @default.
• W2946508770 cites W2074200529 @default.
• W2946508770 cites W2089153751 @default.
• W2946508770 cites W2095468356 @default.
• W2946508770 cites W2123618967 @default.
• W2946508770 cites W2132075674 @default.
• W2946508770 cites W2161817637 @default.
• W2946508770 cites W2235523093 @default.
• W2946508770 cites W2238063610 @default.
• W2946508770 cites W2261241268 @default.
• W2946508770 cites W2268960759 @default.
• W2946508770 cites W2299917232 @default.
• W2946508770 cites W2314877716 @default.
• W2946508770 cites W2327583410 @default.
• W2946508770 cites W2396052837 @default.
• W2946508770 cites W2402257995 @default.
• W2946508770 doi "https://doi.org/10.1177/1533033819846632" @default.
• W2946508770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6535757" @default.
• W2946508770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31106685" @default.
• W2946508770 hasPublicationYear "2019" @default.
• W2946508770 type Work @default.
• W2946508770 sameAs 2946508770 @default.
• W2946508770 citedByCount "16" @default.
• W2946508770 countsByYear W29465087702020 @default.
• W2946508770 countsByYear W29465087702021 @default.
• W2946508770 countsByYear W29465087702022 @default.
• W2946508770 countsByYear W29465087702023 @default.
• W2946508770 crossrefType "journal-article" @default.
• W2946508770 hasAuthorship W2946508770A5009012652 @default.
• W2946508770 hasAuthorship W2946508770A5011671476 @default.
• W2946508770 hasAuthorship W2946508770A5022499603 @default.
• W2946508770 hasAuthorship W2946508770A5022903030 @default.
• W2946508770 hasAuthorship W2946508770A5044521267 @default.
• W2946508770 hasAuthorship W2946508770A5048378293 @default.
• W2946508770 hasAuthorship W2946508770A5058522873 @default.
• W2946508770 hasAuthorship W2946508770A5071701211 @default.
• W2946508770 hasAuthorship W2946508770A5080951657 @default.
• W2946508770 hasBestOaLocation W29465087701 @default.
• W2946508770 hasConcept C126322002 @default.
• W2946508770 hasConcept C143998085 @default.
• W2946508770 hasConcept C151956035 @default.
• W2946508770 hasConcept C170964787 @default.
• W2946508770 hasConcept C190481736 @default.
• W2946508770 hasConcept C2777546739 @default.
• W2946508770 hasConcept C2778019345 @default.
• W2946508770 hasConcept C71924100 @default.
• W2946508770 hasConcept C76318530 @default.
• W2946508770 hasConcept C89560881 @default.
• W2946508770 hasConcept C90924648 @default.
• W2946508770 hasConceptScore W2946508770C126322002 @default.
• W2946508770 hasConceptScore W2946508770C143998085 @default.
• W2946508770 hasConceptScore W2946508770C151956035 @default.
• W2946508770 hasConceptScore W2946508770C170964787 @default.
• W2946508770 hasConceptScore W2946508770C190481736 @default.
• W2946508770 hasConceptScore W2946508770C2777546739 @default.
• W2946508770 hasConceptScore W2946508770C2778019345 @default.
• W2946508770 hasConceptScore W2946508770C71924100 @default.
• W2946508770 hasConceptScore W2946508770C76318530 @default.
• W2946508770 hasConceptScore W2946508770C89560881 @default.
• W2946508770 hasConceptScore W2946508770C90924648 @default.
• W2946508770 hasLocation W29465087701 @default.
• W2946508770 hasLocation W29465087702 @default.
• W2946508770 hasLocation W29465087703 @default.
• W2946508770 hasLocation W29465087704 @default.
• W2946508770 hasOpenAccess W2946508770 @default.
• W2946508770 hasPrimaryLocation W29465087701 @default.
• W2946508770 hasRelatedWork W2020556094 @default.
• W2946508770 hasRelatedWork W2032610926 @default.
• W2946508770 hasRelatedWork W2122443163 @default.
• W2946508770 hasRelatedWork W2156830092 @default.
• W2946508770 hasRelatedWork W2268960759 @default.
• W2946508770 hasRelatedWork W2376404665 @default.

• next