FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946516308> ?p ?o ?g. }

• W2946516308 endingPage "1109" @default.
• W2946516308 startingPage "1095" @default.
• W2946516308 abstract "Parkinson's disease (PD) is a disabling and highly costly neurodegenerative condition with worldwide prevalence. Despite advances in treatments that slow progression and minimize locomotor impairments, its clinical management is still a challenge. Previous preclinical studies, using mesenchymal stem cell (MSC) transplantation and isolated physical exercise (EX), reported beneficial results for treatment of PD. Therefore, this experimental randomized study aimed to elucidate the therapeutic potential of combined therapy using adipose‐derived human MSCs (ADSCs) grafted into the striatum in conjunction with aerobic treadmill training, specifically in terms of locomotor performance in a unilateral PD rat model induced by 6‐hydroxydopamine (6‐OHDA). Forty‐one male Wistar rats were categorized into five groups in accordance with the type of treatment to which they were subjected (Sham, 6‐OHDA − injury, 6‐OHDA + exercise, 6‐OHDA + cells, and 6‐OHDA + combined). Subsequently, dopaminergic depletion was assessed by the methylphenidate challenge and the specified therapeutic intervention was conducted in each group. The foot fault task was performed at the end of the experiment to serve as an assessment of motor skills. The results showed that despite disturbances in motor balance and coordination, locomotor dysfunction was ameliorated in all treatment categories in comparison to the injury group (sign test, p < 0.001, effect size: 0.71). The exercise alone and combined groups were the categories that exhibited the best recovery in terms of movement performance ( p < 0.001). Overall, this study confirms that exercise is a powerful option to improve motor function and a promising adjuvant intervention for stem cell transplantation in the treatment of PD motor symptoms. Open Practices This article has been awarded Open Data. All materials and data are publicly accessible at https://figshare.com/s/18a543c101a17a1d5560 . Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki ." @default.
• W2946516308 created "2019-05-29" @default.
• W2946516308 creator A5004430262 @default.
• W2946516308 creator A5033130694 @default.
• W2946516308 creator A5044569161 @default.
• W2946516308 creator A5050060942 @default.
• W2946516308 creator A5065632056 @default.
• W2946516308 creator A5087876931 @default.
• W2946516308 date "2019-05-22" @default.
• W2946516308 modified "2023-10-16" @default.
• W2946516308 title "Physical exercise and human adipose‐derived mesenchymal stem cells ameliorate motor disturbances in a male rat model of Parkinson's disease" @default.
• W2946516308 cites W1667322406 @default.
• W2946516308 cites W1883072332 @default.
• W2946516308 cites W1974662613 @default.
• W2946516308 cites W1978370369 @default.
• W2946516308 cites W1980505651 @default.
• W2946516308 cites W1991399534 @default.
• W2946516308 cites W1992250466 @default.
• W2946516308 cites W1993241967 @default.
• W2946516308 cites W1998697345 @default.
• W2946516308 cites W2001257598 @default.
• W2946516308 cites W2015799445 @default.
• W2946516308 cites W2016810249 @default.
• W2946516308 cites W2016953038 @default.
• W2946516308 cites W2021421904 @default.
• W2946516308 cites W2022460425 @default.
• W2946516308 cites W2025371271 @default.
• W2946516308 cites W2031056393 @default.
• W2946516308 cites W2032668154 @default.
• W2946516308 cites W2035293165 @default.
• W2946516308 cites W2049393626 @default.
• W2946516308 cites W2051313501 @default.
• W2946516308 cites W2052299360 @default.
• W2946516308 cites W2052448420 @default.
• W2946516308 cites W2054763653 @default.
• W2946516308 cites W2067313980 @default.
• W2946516308 cites W2070648356 @default.
• W2946516308 cites W2072073756 @default.
• W2946516308 cites W2077207851 @default.
• W2946516308 cites W2084388307 @default.
• W2946516308 cites W2091150517 @default.
• W2946516308 cites W2096353737 @default.
• W2946516308 cites W2115836919 @default.
• W2946516308 cites W2118610309 @default.
• W2946516308 cites W2124304098 @default.
• W2946516308 cites W2127214905 @default.
• W2946516308 cites W2131196982 @default.
• W2946516308 cites W2142389530 @default.
• W2946516308 cites W2145826883 @default.
• W2946516308 cites W2148878284 @default.
• W2946516308 cites W2155044423 @default.
• W2946516308 cites W2160959923 @default.
• W2946516308 cites W2161517126 @default.
• W2946516308 cites W2170106855 @default.
• W2946516308 cites W2171507288 @default.
• W2946516308 cites W2269929750 @default.
• W2946516308 cites W2299681973 @default.
• W2946516308 cites W2313796202 @default.
• W2946516308 cites W2314693552 @default.
• W2946516308 cites W2316826747 @default.
• W2946516308 cites W2409435003 @default.
• W2946516308 cites W2503197207 @default.
• W2946516308 cites W2547235897 @default.
• W2946516308 cites W2591649103 @default.
• W2946516308 cites W2593332903 @default.
• W2946516308 cites W2609030733 @default.
• W2946516308 cites W2623996578 @default.
• W2946516308 cites W2751466955 @default.
• W2946516308 cites W2761547692 @default.
• W2946516308 cites W2789693382 @default.
• W2946516308 cites W2884450284 @default.
• W2946516308 doi "https://doi.org/10.1002/jnr.24442" @default.
• W2946516308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31119788" @default.
• W2946516308 hasPublicationYear "2019" @default.
• W2946516308 type Work @default.
• W2946516308 sameAs 2946516308 @default.
• W2946516308 citedByCount "8" @default.
• W2946516308 countsByYear W29465163082019 @default.
• W2946516308 countsByYear W29465163082020 @default.
• W2946516308 countsByYear W29465163082021 @default.
• W2946516308 countsByYear W29465163082022 @default.
• W2946516308 countsByYear W29465163082023 @default.
• W2946516308 crossrefType "journal-article" @default.
• W2946516308 hasAuthorship W2946516308A5004430262 @default.
• W2946516308 hasAuthorship W2946516308A5033130694 @default.
• W2946516308 hasAuthorship W2946516308A5044569161 @default.
• W2946516308 hasAuthorship W2946516308A5050060942 @default.
• W2946516308 hasAuthorship W2946516308A5065632056 @default.
• W2946516308 hasAuthorship W2946516308A5087876931 @default.
• W2946516308 hasConcept C102652120 @default.
• W2946516308 hasConcept C126322002 @default.
• W2946516308 hasConcept C137183658 @default.
• W2946516308 hasConcept C142724271 @default.
• W2946516308 hasConcept C15744967 @default.
• W2946516308 hasConcept C169760540 @default.
• W2946516308 hasConcept C1862650 @default.
• W2946516308 hasConcept C198826908 @default.
• W2946516308 hasConcept C2777981454 @default.

• next