FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946525802> ?p ?o ?g. }

• W2946525802 endingPage "139" @default.
• W2946525802 startingPage "133" @default.
• W2946525802 abstract "Neuronal excitotoxicity is the neuronal cell death arising from prolonged exposure to glutamate and the associated excessive influx of ions into the cell. Sodium orthovanadate (Na3VO4,) competitively inhibits the protein tyrosine phosphatases that affect intracellular protein phosphorylation. No study has examined the role of protein tyrosine phosphatases in kainic acid (KA)-induced excitotoxic injury using sodium orthovanadate. Thus, the present study was conducted to determine the neuroprotective effects of sodium orthovanadate on KA-induced neuronal death in organotypic hippocampal slice culture. We also performed an in vivo electrophysiology study in Sprague-Dawley rats to observe the function of surviving cells after sodium orthovanadate treatment in KA-induced excitotoxicity. Rats were anaesthetized with sodium pentobarbital and KA was injected unilaterally in CA3 of the hippocampus by microinjection-cannula. Neuronal cell death, as assessed by propidium iodide uptake, was reduced by 10 and 25 μM sodium orthovanadate treatment (24 and 48 h) compared with the KA-only group. Sodium orthovanadate enhanced survival signals by increasing levels of phospho-Akt and superoxide dismutase. In addition, sodium orthovanadate treatment reduced calcineurin level for neuronal protection, which regulates activation of cellular calcium caused by KA-induced injury. In vivo results showed that sodium orthovanadate treatment elicited resistance to KA-induced behavior seizures and significantly reduced the duration of epileptiform discharges. In addition, sodium orthovanadate treatment (25 mM) significantly prevented the increase in power spectra induced by KA injection. These results suggest that sodium orthovanadate decreases the acute effects of KA, thereby inducing neuroprotective effects with reduced reactive oxygen species and cellular Ca2+. Thus, sodium orthovanadate may protect hippocampal neurons against excitotoxicity, and surviving neurons may function to reduce seizures." @default.
• W2946525802 created "2019-05-29" @default.
• W2946525802 creator A5017201856 @default.
• W2946525802 creator A5048145361 @default.
• W2946525802 creator A5072706713 @default.
• W2946525802 date "2019-09-01" @default.
• W2946525802 modified "2023-09-24" @default.
• W2946525802 title "Neuroprotective effects of a protein tyrosine phosphatase inhibitor against hippocampal excitotoxic injury" @default.
• W2946525802 cites W1536916610 @default.
• W2946525802 cites W1594117694 @default.
• W2946525802 cites W1932209067 @default.
• W2946525802 cites W1967029484 @default.
• W2946525802 cites W1968517066 @default.
• W2946525802 cites W1969521771 @default.
• W2946525802 cites W1970237948 @default.
• W2946525802 cites W1970638737 @default.
• W2946525802 cites W1974903553 @default.
• W2946525802 cites W1985464084 @default.
• W2946525802 cites W1991939753 @default.
• W2946525802 cites W1992855623 @default.
• W2946525802 cites W1994475416 @default.
• W2946525802 cites W2010395951 @default.
• W2946525802 cites W2016821035 @default.
• W2946525802 cites W2018726899 @default.
• W2946525802 cites W2021117527 @default.
• W2946525802 cites W2027397876 @default.
• W2946525802 cites W2032429514 @default.
• W2946525802 cites W2032659471 @default.
• W2946525802 cites W2037438294 @default.
• W2946525802 cites W2045708387 @default.
• W2946525802 cites W2055789300 @default.
• W2946525802 cites W2057713336 @default.
• W2946525802 cites W2059913895 @default.
• W2946525802 cites W2060395669 @default.
• W2946525802 cites W2069782346 @default.
• W2946525802 cites W2078607325 @default.
• W2946525802 cites W2079054696 @default.
• W2946525802 cites W2079239821 @default.
• W2946525802 cites W2079439105 @default.
• W2946525802 cites W2101178075 @default.
• W2946525802 cites W2103946141 @default.
• W2946525802 cites W2104474697 @default.
• W2946525802 cites W2123858681 @default.
• W2946525802 cites W2128495200 @default.
• W2946525802 cites W2132787891 @default.
• W2946525802 cites W2169424710 @default.
• W2946525802 cites W2275152065 @default.
• W2946525802 cites W2348503361 @default.
• W2946525802 cites W2766783520 @default.
• W2946525802 cites W2800173737 @default.
• W2946525802 cites W3027709275 @default.
• W2946525802 cites W757575373 @default.
• W2946525802 doi "https://doi.org/10.1016/j.brainres.2019.05.027" @default.
• W2946525802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31128098" @default.
• W2946525802 hasPublicationYear "2019" @default.
• W2946525802 type Work @default.
• W2946525802 sameAs 2946525802 @default.
• W2946525802 citedByCount "13" @default.
• W2946525802 countsByYear W29465258022020 @default.
• W2946525802 countsByYear W29465258022021 @default.
• W2946525802 countsByYear W29465258022022 @default.
• W2946525802 countsByYear W29465258022023 @default.
• W2946525802 crossrefType "journal-article" @default.
• W2946525802 hasAuthorship W2946525802A5017201856 @default.
• W2946525802 hasAuthorship W2946525802A5048145361 @default.
• W2946525802 hasAuthorship W2946525802A5072706713 @default.
• W2946525802 hasConcept C126322002 @default.
• W2946525802 hasConcept C134018914 @default.
• W2946525802 hasConcept C185592680 @default.
• W2946525802 hasConcept C190283241 @default.
• W2946525802 hasConcept C25498285 @default.
• W2946525802 hasConcept C2776165026 @default.
• W2946525802 hasConcept C2777553839 @default.
• W2946525802 hasConcept C2779417574 @default.
• W2946525802 hasConcept C2781012912 @default.
• W2946525802 hasConcept C31573885 @default.
• W2946525802 hasConcept C55493867 @default.
• W2946525802 hasConcept C71924100 @default.
• W2946525802 hasConcept C85528070 @default.
• W2946525802 hasConcept C86803240 @default.
• W2946525802 hasConcept C98274493 @default.
• W2946525802 hasConceptScore W2946525802C126322002 @default.
• W2946525802 hasConceptScore W2946525802C134018914 @default.
• W2946525802 hasConceptScore W2946525802C185592680 @default.
• W2946525802 hasConceptScore W2946525802C190283241 @default.
• W2946525802 hasConceptScore W2946525802C25498285 @default.
• W2946525802 hasConceptScore W2946525802C2776165026 @default.
• W2946525802 hasConceptScore W2946525802C2777553839 @default.
• W2946525802 hasConceptScore W2946525802C2779417574 @default.
• W2946525802 hasConceptScore W2946525802C2781012912 @default.
• W2946525802 hasConceptScore W2946525802C31573885 @default.
• W2946525802 hasConceptScore W2946525802C55493867 @default.
• W2946525802 hasConceptScore W2946525802C71924100 @default.
• W2946525802 hasConceptScore W2946525802C85528070 @default.
• W2946525802 hasConceptScore W2946525802C86803240 @default.
• W2946525802 hasConceptScore W2946525802C98274493 @default.
• W2946525802 hasFunder F4320322120 @default.
• W2946525802 hasLocation W29465258021 @default.

• next