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• W2946572191 abstract "To investigate the protective effect of oral Vitamin C on DNA double-strand breaks (DSBs) after abdominal contrast-enhanced CT examination. Sixty patients undergoing abdominal multiphase contrast-enhanced CT were divided into control group (n = 30) and prevention group (n = 30). Patients in the prevention group were orally administered 1 g Vitamin C 30–120 minutes prior to CT examination. Blood samples were obtained prior to and 5 min following CT examination for each subject. γ-H2AX foci representing DSBs in the nucleus of lymphocytes were marked by fluorescent markers. Change in γ-H2AX foci/cell was compared through Student t-tests or ANOVA testing. The relationship between physical parameters and increase in γ-H2AX foci was analyzed through Pearson or Spearman correlation analysis. The mean increase in γ-H2AX was 0.49 foci /cell in the control group and 0.19 foci/cell in the prevention group (p < 0.001), corresponding to a 61% reduction in the mean increase in γ-H2AX foci in the prevention group compared to the control group. In the prevention group, increase in γ-H2AX foci/cell positively correlated with dose length product and volume CT dose index (r = 0.449 and 0.403, respectively; both p < 0.05). No difference in the increase in γ-H2AX foci/cell was found between the different time interval subgroups of 30, 60, and 120 min between Vitamin C administration and CT examination (p > 0.05). Oral Vitamin C can significantly reduce the level of DSBs after abdominal contrast-enhanced CT examination and is a simple and effective method to decrease DNA damage." @default.
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• W2946572191 date "2019-08-01" @default.
• W2946572191 modified "2023-10-17" @default.
• W2946572191 title "The effect of prophylactic oral vitamin C use on DNA double-strand breaks after abdominal contrast-enhanced CT: A preliminary study" @default.
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• W2946572191 doi "https://doi.org/10.1016/j.ejrad.2019.05.020" @default.
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