Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946596746> ?p ?o ?g. }
- W2946596746 endingPage "1934" @default.
- W2946596746 startingPage "1934" @default.
- W2946596746 abstract "Aconitum carmichaeli with Ampelopsis japonica (AA) is a classical traditional Chinese medicine (TCM) formula. There are a lot of examples showing that AA can be used to treat rheumatoid arthritis, but its mechanism of action is still not completely clear. In this research, collagen-induced arthritis (CIA) was chosen as a rheumatoid arthritis (RA) model. Rats of treated groups were continuously administered Aconitum carmichaeli (AC), Ampelopsis japonica (AJ) and Aconitum carmichaeli + Ampelopsis japonica (AA) orally once a day from the day after the onset of arthritis (day 7) until day 42. The results showed that AA not only significantly reduced paw swelling, but also improved the levels of TNF-α and IL-6 in serum. GC-MS-based urine metabonomics was established to analysis metabolic profiles and 21 biomarkers of RA rats were identified by the Partial Least Squares Discriminant Analysis (PLS-DA) and Support Vector Machine (SVM) methods. The prediction rate of the SVM method for the 21 biomarkers was 100%. Twenty of 21 biomarkers, including D-galactose, inositol and glycerol, gradually returned to normal levels after administration of AA. Metabolomic Pathway Analysis (MetPA) generated three related metabolic pathways—galactose metabolism, glycerolipid metabolism and inositol phosphate metabolism—which explain the mechanism of AA treatment of rheumatoid arthritis. This research provides a better understanding of the therapeutic effects and possible therapeutic mechanism of action of a complex TCM (AA) on rheumatoid arthritis." @default.
- W2946596746 created "2019-05-29" @default.
- W2946596746 creator A5002336177 @default.
- W2946596746 creator A5002986938 @default.
- W2946596746 creator A5007646857 @default.
- W2946596746 creator A5022526821 @default.
- W2946596746 creator A5055398659 @default.
- W2946596746 creator A5067223695 @default.
- W2946596746 date "2019-05-20" @default.
- W2946596746 modified "2023-10-18" @default.
- W2946596746 title "Application of GC/MS-Based Metabonomic Profiling in Studying the Therapeutic Effects of Aconitum carmichaeli with Ampelopsis japonica Extract on Collagen-Induced Arthritis in Rats" @default.
- W2946596746 cites W1539472260 @default.
- W2946596746 cites W1584992729 @default.
- W2946596746 cites W1595900569 @default.
- W2946596746 cites W1878937427 @default.
- W2946596746 cites W1968851649 @default.
- W2946596746 cites W1976664639 @default.
- W2946596746 cites W1981173277 @default.
- W2946596746 cites W1995974513 @default.
- W2946596746 cites W2015499663 @default.
- W2946596746 cites W2021539595 @default.
- W2946596746 cites W2046083655 @default.
- W2946596746 cites W2068701230 @default.
- W2946596746 cites W2081480383 @default.
- W2946596746 cites W2088740557 @default.
- W2946596746 cites W2152611039 @default.
- W2946596746 cites W2153379984 @default.
- W2946596746 cites W2162194782 @default.
- W2946596746 cites W2162279628 @default.
- W2946596746 cites W2168711492 @default.
- W2946596746 cites W2262525353 @default.
- W2946596746 cites W2302845541 @default.
- W2946596746 cites W2325506294 @default.
- W2946596746 cites W2346676516 @default.
- W2946596746 cites W2512910707 @default.
- W2946596746 cites W2547527175 @default.
- W2946596746 cites W2573870881 @default.
- W2946596746 cites W2582150691 @default.
- W2946596746 cites W2582867584 @default.
- W2946596746 cites W2587034866 @default.
- W2946596746 cites W2593330790 @default.
- W2946596746 cites W2611353715 @default.
- W2946596746 cites W2613002864 @default.
- W2946596746 cites W2613462240 @default.
- W2946596746 cites W2618045236 @default.
- W2946596746 cites W2744290711 @default.
- W2946596746 cites W2750648640 @default.
- W2946596746 cites W2752665788 @default.
- W2946596746 cites W2754748917 @default.
- W2946596746 cites W2765998662 @default.
- W2946596746 cites W2766692063 @default.
- W2946596746 cites W279592115 @default.
- W2946596746 cites W2891278040 @default.
- W2946596746 cites W2892183154 @default.
- W2946596746 cites W2901953110 @default.
- W2946596746 cites W4210968471 @default.
- W2946596746 cites W4246816614 @default.
- W2946596746 cites W640136745 @default.
- W2946596746 doi "https://doi.org/10.3390/molecules24101934" @default.
- W2946596746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6571615" @default.
- W2946596746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31137469" @default.
- W2946596746 hasPublicationYear "2019" @default.
- W2946596746 type Work @default.
- W2946596746 sameAs 2946596746 @default.
- W2946596746 citedByCount "14" @default.
- W2946596746 countsByYear W29465967462019 @default.
- W2946596746 countsByYear W29465967462020 @default.
- W2946596746 countsByYear W29465967462021 @default.
- W2946596746 countsByYear W29465967462022 @default.
- W2946596746 countsByYear W29465967462023 @default.
- W2946596746 crossrefType "journal-article" @default.
- W2946596746 hasAuthorship W2946596746A5002336177 @default.
- W2946596746 hasAuthorship W2946596746A5002986938 @default.
- W2946596746 hasAuthorship W2946596746A5007646857 @default.
- W2946596746 hasAuthorship W2946596746A5022526821 @default.
- W2946596746 hasAuthorship W2946596746A5055398659 @default.
- W2946596746 hasAuthorship W2946596746A5067223695 @default.
- W2946596746 hasBestOaLocation W29465967461 @default.
- W2946596746 hasConcept C126322002 @default.
- W2946596746 hasConcept C185592680 @default.
- W2946596746 hasConcept C2777077863 @default.
- W2946596746 hasConcept C2777575956 @default.
- W2946596746 hasConcept C2777667214 @default.
- W2946596746 hasConcept C2780029364 @default.
- W2946596746 hasConcept C556039675 @default.
- W2946596746 hasConcept C71240020 @default.
- W2946596746 hasConcept C71924100 @default.
- W2946596746 hasConcept C98274493 @default.
- W2946596746 hasConceptScore W2946596746C126322002 @default.
- W2946596746 hasConceptScore W2946596746C185592680 @default.
- W2946596746 hasConceptScore W2946596746C2777077863 @default.
- W2946596746 hasConceptScore W2946596746C2777575956 @default.
- W2946596746 hasConceptScore W2946596746C2777667214 @default.
- W2946596746 hasConceptScore W2946596746C2780029364 @default.
- W2946596746 hasConceptScore W2946596746C556039675 @default.
- W2946596746 hasConceptScore W2946596746C71240020 @default.
- W2946596746 hasConceptScore W2946596746C71924100 @default.
- W2946596746 hasConceptScore W2946596746C98274493 @default.