Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946623481> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2946623481 abstract "Studies using interference contrast microscopy (Nomarski optics) with immediate glutaraldehyde fixation of blood at venepuncture revealed the disc like shape of native thrombocytes. Soon after blood drawing platelets in citrate blood or PRP are swelling and the formation of pseudopodes can be observed. If citrate blood is incubated at 37°C, 38% of the thrombocytes have formed pseudopodes after 30 min. The form variation is inhibited in some platelet defects (storage pool disease, aspirin like defect) and is enhanced in certain malignancies (Hodgkin’s disease, bronchial carcinoma). After oral intake or intravenous administration of 1.0 g ASA the primary shape change is partly inhibited for a period of six hrs. with the greatest effect at two hrs. In contrast to this short lasting effect on primary shape change the inhibition of ADP or collagen-induced aggregation by a single dose of ASA can be demonstrated for at least four days. We suggest that the short lasting inhibition of the primary shape change of platelets may be responsible for the efficacy of ASA in postoperative thrombosis prophylaxis. Regular intake of ASA in doses of 0.5 g each at 6 - 8 hrs. intervals may be necessary to achieve a continuous antithrombotic effect. Our results may explain why studies on thrombosis prophylaxis with aspirin using 0.6 g (BMRC, 1973) or 0.3 g (Elwood, 1974) per day were inconclusive whereas 3 × 0.5 g reduced the thrombosis frequency significantly (Zekert, 1973, Loew, 1973)." @default.
- W2946623481 created "2019-05-29" @default.
- W2946623481 creator A5003152152 @default.
- W2946623481 creator A5058317449 @default.
- W2946623481 date "1977-01-01" @default.
- W2946623481 modified "2023-09-23" @default.
- W2946623481 title "Primary Shape Change of Thrombocytes and Platelet Aggregation after Administration of Acetyl Salicylic Acid (ASA)" @default.
- W2946623481 doi "https://doi.org/10.1055/s-0039-1680753" @default.
- W2946623481 hasPublicationYear "1977" @default.
- W2946623481 type Work @default.
- W2946623481 sameAs 2946623481 @default.
- W2946623481 citedByCount "0" @default.
- W2946623481 crossrefType "proceedings-article" @default.
- W2946623481 hasAuthorship W2946623481A5003152152 @default.
- W2946623481 hasAuthorship W2946623481A5058317449 @default.
- W2946623481 hasBestOaLocation W29466234811 @default.
- W2946623481 hasConcept C121332964 @default.
- W2946623481 hasConcept C126322002 @default.
- W2946623481 hasConcept C1276947 @default.
- W2946623481 hasConcept C185592680 @default.
- W2946623481 hasConcept C2777977315 @default.
- W2946623481 hasConcept C2778221352 @default.
- W2946623481 hasConcept C2993802102 @default.
- W2946623481 hasConcept C55493867 @default.
- W2946623481 hasConcept C71924100 @default.
- W2946623481 hasConcept C89560881 @default.
- W2946623481 hasConcept C98274493 @default.
- W2946623481 hasConceptScore W2946623481C121332964 @default.
- W2946623481 hasConceptScore W2946623481C126322002 @default.
- W2946623481 hasConceptScore W2946623481C1276947 @default.
- W2946623481 hasConceptScore W2946623481C185592680 @default.
- W2946623481 hasConceptScore W2946623481C2777977315 @default.
- W2946623481 hasConceptScore W2946623481C2778221352 @default.
- W2946623481 hasConceptScore W2946623481C2993802102 @default.
- W2946623481 hasConceptScore W2946623481C55493867 @default.
- W2946623481 hasConceptScore W2946623481C71924100 @default.
- W2946623481 hasConceptScore W2946623481C89560881 @default.
- W2946623481 hasConceptScore W2946623481C98274493 @default.
- W2946623481 hasLocation W29466234811 @default.
- W2946623481 hasOpenAccess W2946623481 @default.
- W2946623481 hasPrimaryLocation W29466234811 @default.
- W2946623481 hasRelatedWork W1970896764 @default.
- W2946623481 hasRelatedWork W1976058901 @default.
- W2946623481 hasRelatedWork W1995617609 @default.
- W2946623481 hasRelatedWork W2002578311 @default.
- W2946623481 hasRelatedWork W2009374304 @default.
- W2946623481 hasRelatedWork W2029582166 @default.
- W2946623481 hasRelatedWork W2033215753 @default.
- W2946623481 hasRelatedWork W2036365886 @default.
- W2946623481 hasRelatedWork W2037116480 @default.
- W2946623481 hasRelatedWork W2051739276 @default.
- W2946623481 hasRelatedWork W2063683333 @default.
- W2946623481 hasRelatedWork W2086927607 @default.
- W2946623481 hasRelatedWork W2135078955 @default.
- W2946623481 hasRelatedWork W2157938924 @default.
- W2946623481 hasRelatedWork W2313501074 @default.
- W2946623481 hasRelatedWork W2324158024 @default.
- W2946623481 hasRelatedWork W2472469044 @default.
- W2946623481 hasRelatedWork W2908915780 @default.
- W2946623481 hasRelatedWork W2994032380 @default.
- W2946623481 hasRelatedWork W395437453 @default.
- W2946623481 isParatext "false" @default.
- W2946623481 isRetracted "false" @default.
- W2946623481 magId "2946623481" @default.
- W2946623481 workType "article" @default.