Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946626617> ?p ?o ?g. }
- W2946626617 abstract "ABSTRACT Although overexpression of EZH2, a catalytic subunit of the polycomb repressive complex 2 (PRC2), is an eminent feature of various cancers, the regulation of its abundance and function remains insufficiently understood. We report here that the PRC2 complex is physically associated with ubiquitin-specific protease USP7 in melanoma cells where USP7 acts to deubiquitinate and stabilize EZH2. Interestingly, we found that USP7-catalyzed H2BK120 deubiquitination is a prerequisite for chromatin loading of PRC2 thus H3K27 trimethylation. Genome-wide analysis of the transcriptional targets of the USP7/PRC2 complex identified a cohort of genes including FOXO1 that are involved in cell growth and proliferation. We demonstrated that the USP7/PRC2 complex drives melanoma cell proliferation and tumorigenesis in vitro and in vivo. We showed that the expression of both USP7 and EZH2 elevates during melanoma progression, corresponding to a diminished FOXO1 expression, and the level of the expression of USP7 and EZH2 strongly correlates with histological grades and prognosis of melanoma patients. These results reveal a dual role for USP7 in the regulation of the abundance and function of EZH2, supporting the pursuit of USP7 as a therapeutic target for melanoma." @default.
- W2946626617 created "2019-05-29" @default.
- W2946626617 creator A5003291075 @default.
- W2946626617 creator A5005451961 @default.
- W2946626617 creator A5006434667 @default.
- W2946626617 creator A5007865045 @default.
- W2946626617 creator A5011859684 @default.
- W2946626617 creator A5032739414 @default.
- W2946626617 creator A5033532580 @default.
- W2946626617 creator A5036860312 @default.
- W2946626617 creator A5044642504 @default.
- W2946626617 creator A5046732096 @default.
- W2946626617 creator A5049632780 @default.
- W2946626617 creator A5051577475 @default.
- W2946626617 creator A5055714690 @default.
- W2946626617 creator A5086115826 @default.
- W2946626617 creator A5086822002 @default.
- W2946626617 creator A5087496453 @default.
- W2946626617 date "2019-05-18" @default.
- W2946626617 modified "2023-09-27" @default.
- W2946626617 title "Bimodal Regulation of the PRC2 Complex by USP7 Underlies Melanomagenesis" @default.
- W2946626617 cites W1820576557 @default.
- W2946626617 cites W1959935957 @default.
- W2946626617 cites W1963996414 @default.
- W2946626617 cites W1969485334 @default.
- W2946626617 cites W1979833232 @default.
- W2946626617 cites W1980300257 @default.
- W2946626617 cites W1983774108 @default.
- W2946626617 cites W1987742709 @default.
- W2946626617 cites W1988129083 @default.
- W2946626617 cites W1993628118 @default.
- W2946626617 cites W1994020081 @default.
- W2946626617 cites W1996487270 @default.
- W2946626617 cites W1998971866 @default.
- W2946626617 cites W2001900537 @default.
- W2946626617 cites W2004608668 @default.
- W2946626617 cites W2009403023 @default.
- W2946626617 cites W2020877539 @default.
- W2946626617 cites W2025031118 @default.
- W2946626617 cites W2027603142 @default.
- W2946626617 cites W2032741035 @default.
- W2946626617 cites W2034203447 @default.
- W2946626617 cites W2045907249 @default.
- W2946626617 cites W2052874737 @default.
- W2946626617 cites W2054938702 @default.
- W2946626617 cites W2056419964 @default.
- W2946626617 cites W2056677650 @default.
- W2946626617 cites W2058513399 @default.
- W2946626617 cites W2060608189 @default.
- W2946626617 cites W2072009397 @default.
- W2946626617 cites W2072722847 @default.
- W2946626617 cites W2080550392 @default.
- W2946626617 cites W2080863734 @default.
- W2946626617 cites W2082231793 @default.
- W2946626617 cites W2082668371 @default.
- W2946626617 cites W2085076961 @default.
- W2946626617 cites W2099364141 @default.
- W2946626617 cites W2108688207 @default.
- W2946626617 cites W2127217324 @default.
- W2946626617 cites W2147370638 @default.
- W2946626617 cites W2150456795 @default.
- W2946626617 cites W2157785920 @default.
- W2946626617 cites W2161145604 @default.
- W2946626617 cites W2163132857 @default.
- W2946626617 cites W2168837438 @default.
- W2946626617 cites W2171953865 @default.
- W2946626617 cites W2187478032 @default.
- W2946626617 cites W2218128634 @default.
- W2946626617 cites W2253174922 @default.
- W2946626617 cites W2254594392 @default.
- W2946626617 cites W2326834262 @default.
- W2946626617 cites W2338736378 @default.
- W2946626617 cites W2381681988 @default.
- W2946626617 cites W2400942913 @default.
- W2946626617 cites W2408873913 @default.
- W2946626617 cites W2510586636 @default.
- W2946626617 cites W2560140650 @default.
- W2946626617 cites W2592240998 @default.
- W2946626617 cites W2593283143 @default.
- W2946626617 cites W2754447749 @default.
- W2946626617 cites W2775617137 @default.
- W2946626617 cites W2806332662 @default.
- W2946626617 cites W2887455839 @default.
- W2946626617 cites W2889660697 @default.
- W2946626617 cites W2890820474 @default.
- W2946626617 cites W2898452673 @default.
- W2946626617 cites W2905324652 @default.
- W2946626617 doi "https://doi.org/10.1101/641977" @default.
- W2946626617 hasPublicationYear "2019" @default.
- W2946626617 type Work @default.
- W2946626617 sameAs 2946626617 @default.
- W2946626617 citedByCount "0" @default.
- W2946626617 crossrefType "posted-content" @default.
- W2946626617 hasAuthorship W2946626617A5003291075 @default.
- W2946626617 hasAuthorship W2946626617A5005451961 @default.
- W2946626617 hasAuthorship W2946626617A5006434667 @default.
- W2946626617 hasAuthorship W2946626617A5007865045 @default.
- W2946626617 hasAuthorship W2946626617A5011859684 @default.
- W2946626617 hasAuthorship W2946626617A5032739414 @default.
- W2946626617 hasAuthorship W2946626617A5033532580 @default.