FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946629268> ?p ?o ?g. }

• W2946629268 abstract "The impact of Tet oncogene family member 2 (TET2) mutations on the prognosis of acute myeloid leukemia (AML) is still controversial. A meta analysis is needed in order to assess the prognostic significance of TET2 mutation in AML.Five databases including PubMed, Cochrane, EMBase, China National Knowledge Internet (CNKI) and Wanfang database were retrieved to search studies that investigated the correlation between TET2 mutations and outcomes of AML patients. Pooled hazard ratios (HRs) and odds ratios (ORs) were used to assess the effects of TET2 mutations.Sixteen studies were included. TET2 mutation was an unfavorable prognostic factor for overall survival (OS: HR = 1.386; P < 0.001) and event-free survival (EFS: HR = 1.594; P = 0.002) in patients with AML. For patients under 65 years of age, TET2 mutation predicted an inferior OS (HR = 1.310, P = 0.051) and EFS (HR = 1.429, P = 0.027). For patients with intermediate-risk cytogenetics (IR-AML), mutant TET2 had a significant association with adverse OS (HR = 0.474; P < 0.001). For patients with normal cytogenetics (CN-AML), mutant TET2 also conferred adverse OS (HR = 1.425; P < 0.001) and EFS (HR = 1.450, P < 0.001). Further, among patients with CN-AML, mutant TET2 was associated with inferior OS (HR = 2.034, P < 0.001) and EFS (HR = 2.140, P < 0.001) in the ELN favorable-risk subgroup and an inferior EFS (HR = 1.487; P < 0.001) in the ELN intermediate-Isubgroup. With respect to treatment outcome, TET2 mutation predicted a significantly lower rate of complete remission (CR) in cases with ELN favorable-risk cytogenetics (OR = 0.460, P = 0.011).TET2 mutation had adverse impacts on survival and treatment response in AML patients and will contribute to risk-stratification, prognosis prediction and therapy guidance." @default.
• W2946629268 created "2019-05-29" @default.
• W2946629268 creator A5012949929 @default.
• W2946629268 creator A5044400826 @default.
• W2946629268 creator A5062966442 @default.
• W2946629268 date "2019-04-25" @default.
• W2946629268 modified "2023-10-04" @default.
• W2946629268 title "The prognostic impact of tet oncogene family member 2 mutations in patients with acute myeloid leukemia: a systematic-review and meta-analysis" @default.
• W2946629268 cites W1533776898 @default.
• W2946629268 cites W1865212210 @default.
• W2946629268 cites W1901332523 @default.
• W2946629268 cites W1966683139 @default.
• W2946629268 cites W2005458309 @default.
• W2946629268 cites W2012080286 @default.
• W2946629268 cites W2029093072 @default.
• W2946629268 cites W2047575731 @default.
• W2946629268 cites W2051293191 @default.
• W2946629268 cites W2055596077 @default.
• W2946629268 cites W2063260586 @default.
• W2946629268 cites W2073872690 @default.
• W2946629268 cites W2080433813 @default.
• W2946629268 cites W2081895311 @default.
• W2946629268 cites W2082365047 @default.
• W2946629268 cites W2109150359 @default.
• W2946629268 cites W2115707319 @default.
• W2946629268 cites W2125482846 @default.
• W2946629268 cites W2131072337 @default.
• W2946629268 cites W2135003681 @default.
• W2946629268 cites W2157287007 @default.
• W2946629268 cites W2164059454 @default.
• W2946629268 cites W2165942330 @default.
• W2946629268 cites W2257349178 @default.
• W2946629268 cites W2277597240 @default.
• W2946629268 cites W2319219705 @default.
• W2946629268 cites W2470053912 @default.
• W2946629268 cites W2559537906 @default.
• W2946629268 cites W2567727571 @default.
• W2946629268 cites W2570618306 @default.
• W2946629268 cites W2592164001 @default.
• W2946629268 cites W4238020764 @default.
• W2946629268 doi "https://doi.org/10.1186/s12885-019-5602-8" @default.
• W2946629268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6485112" @default.
• W2946629268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31023266" @default.
• W2946629268 hasPublicationYear "2019" @default.
• W2946629268 type Work @default.
• W2946629268 sameAs 2946629268 @default.
• W2946629268 citedByCount "28" @default.
• W2946629268 countsByYear W29466292682020 @default.
• W2946629268 countsByYear W29466292682021 @default.
• W2946629268 countsByYear W29466292682022 @default.
• W2946629268 countsByYear W29466292682023 @default.
• W2946629268 crossrefType "journal-article" @default.
• W2946629268 hasAuthorship W2946629268A5012949929 @default.
• W2946629268 hasAuthorship W2946629268A5044400826 @default.
• W2946629268 hasAuthorship W2946629268A5062966442 @default.
• W2946629268 hasBestOaLocation W29466292681 @default.
• W2946629268 hasConcept C104317684 @default.
• W2946629268 hasConcept C126322002 @default.
• W2946629268 hasConcept C143998085 @default.
• W2946629268 hasConcept C156957248 @default.
• W2946629268 hasConcept C187960798 @default.
• W2946629268 hasConcept C207103383 @default.
• W2946629268 hasConcept C2778729363 @default.
• W2946629268 hasConcept C44249647 @default.
• W2946629268 hasConcept C501734568 @default.
• W2946629268 hasConcept C54355233 @default.
• W2946629268 hasConcept C71924100 @default.
• W2946629268 hasConcept C86803240 @default.
• W2946629268 hasConcept C90924648 @default.
• W2946629268 hasConcept C95190672 @default.
• W2946629268 hasConceptScore W2946629268C104317684 @default.
• W2946629268 hasConceptScore W2946629268C126322002 @default.
• W2946629268 hasConceptScore W2946629268C143998085 @default.
• W2946629268 hasConceptScore W2946629268C156957248 @default.
• W2946629268 hasConceptScore W2946629268C187960798 @default.
• W2946629268 hasConceptScore W2946629268C207103383 @default.
• W2946629268 hasConceptScore W2946629268C2778729363 @default.
• W2946629268 hasConceptScore W2946629268C44249647 @default.
• W2946629268 hasConceptScore W2946629268C501734568 @default.
• W2946629268 hasConceptScore W2946629268C54355233 @default.
• W2946629268 hasConceptScore W2946629268C71924100 @default.
• W2946629268 hasConceptScore W2946629268C86803240 @default.
• W2946629268 hasConceptScore W2946629268C90924648 @default.
• W2946629268 hasConceptScore W2946629268C95190672 @default.
• W2946629268 hasFunder F4320321001 @default.
• W2946629268 hasIssue "1" @default.
• W2946629268 hasLocation W29466292681 @default.
• W2946629268 hasLocation W29466292682 @default.
• W2946629268 hasLocation W29466292683 @default.
• W2946629268 hasLocation W29466292684 @default.
• W2946629268 hasOpenAccess W2946629268 @default.
• W2946629268 hasPrimaryLocation W29466292681 @default.
• W2946629268 hasRelatedWork W2106574415 @default.
• W2946629268 hasRelatedWork W2156268606 @default.
• W2946629268 hasRelatedWork W2166206561 @default.
• W2946629268 hasRelatedWork W2286371484 @default.
• W2946629268 hasRelatedWork W2393916661 @default.
• W2946629268 hasRelatedWork W2889691785 @default.
• W2946629268 hasRelatedWork W2945714876 @default.
• W2946629268 hasRelatedWork W3027072643 @default.

• next