FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946630268> ?p ?o ?g. }

• W2946630268 endingPage "H356" @default.
• W2946630268 startingPage "H345" @default.
• W2946630268 abstract "Intracoronary cardiosphere-derived cells (icCDCs) infused into the infarct-related artery reduce scar volume but do not improve left ventricular (LV) ejection fraction (LVEF). We tested the hypothesis that this reflects the inability of regional delivery to prevent myocyte death or promote myocyte proliferation in viable myocardium remote from the infarct. Swine (n = 23) pretreated with oral cyclosporine (200 mg/day) underwent a 1-h left anterior descending coronary artery (LAD) occlusion, which reduced LVEF from 61.6 ± 1.0 to 45.3 ± 1.5% 30 min after reperfusion. At that time, animals received global infusion of allogeneic icCDCs (n = 8), regional infusion of icCDCs restricted to the LAD using the stop-flow technique (n = 8), or vehicle (n = 7). After 1 mo, global icCDCs increased LVEF from 44.8 ± 1.9 to 60.8 ± 3.8% (P < 0.05) with no significant change after LAD stop-flow icCDCs (44.8 ± 3.6 to 50.9 ± 3.1%) or vehicle (46.5 ± 2.5 to 47.7 ± 2.6%). In contrast, global icCDCs did not alter infarct volume (%LV mass) assessed at 2 days (11.2 ± 2.3 vs. 12.6 ± 2.3%), whereas it was reduced after LAD stop-flow icCDCs (7.1 ± 1.1%, P < 0.05). Histopathological analysis of remote myocardium after global icCDCs demonstrated a significant increase in myocyte proliferation (147 ± 32 vs. 14 ± 10 nuclei/106 myocytes, P < 0.05) and a reduction in myocyte apoptosis (15 ± 9 vs. 46 ± 10 nuclei/106 myocytes, P < 0.05) that increased myocyte nuclear density (1,264 ± 39 vs. 1,157 ± 33 nuclei/mm2, P < 0.05) and decreased myocyte diameter (13.2 ± 0.2 vs. 14.5 ± 0.3 μm, P < 0.05) compared with vehicle-treated controls. In contrast, remote zone changes after regional LAD icCDCs were no different from vehicle. These data indicate that changes in global LVEF after icCDCs are dependent upon preventing myocyte loss and hypertrophy in myocardium remote from the infarct. These arise from stimulating myocyte proliferation and reducing myocyte apoptosis indicating the importance of directing cell therapy to viable remote regions.NEW & NOTEWORTHY Administration of allogeneic cardiosphere-derived cells to the entire heart via global intracoronary infusion shortly after myocardial infarction favorably influenced left ventricular ejection fraction by preventing myocyte death and promoting myocyte proliferation in remote, noninfarcted myocardium in swine. In contrast, regional intracoronary cell infusion did not significantly affect remote zone myocyte remodeling. Global cell administration targeting viable myocardium remote from the infarct may be an effective approach to prevent adverse ventricular remodeling after myocardial infarction." @default.
• W2946630268 created "2019-05-29" @default.
• W2946630268 creator A5006467882 @default.
• W2946630268 creator A5006852480 @default.
• W2946630268 creator A5041664116 @default.
• W2946630268 creator A5058617556 @default.
• W2946630268 creator A5080813480 @default.
• W2946630268 date "2019-08-01" @default.
• W2946630268 modified "2023-10-17" @default.
• W2946630268 title "Nonocclusive multivessel intracoronary infusion of allogeneic cardiosphere-derived cells early after reperfusion prevents remote zone myocyte loss and improves global left ventricular function in swine with myocardial infarction" @default.
• W2946630268 cites W1646382336 @default.
• W2946630268 cites W180820775 @default.
• W2946630268 cites W2005415709 @default.
• W2946630268 cites W2033713549 @default.
• W2946630268 cites W2043456930 @default.
• W2946630268 cites W2050202539 @default.
• W2946630268 cites W2051968888 @default.
• W2946630268 cites W2067591094 @default.
• W2946630268 cites W2072039214 @default.
• W2946630268 cites W2080539468 @default.
• W2946630268 cites W2080653064 @default.
• W2946630268 cites W2086108055 @default.
• W2946630268 cites W2092512238 @default.
• W2946630268 cites W2096650620 @default.
• W2946630268 cites W2103111354 @default.
• W2946630268 cites W2107829771 @default.
• W2946630268 cites W2112777549 @default.
• W2946630268 cites W2125235243 @default.
• W2946630268 cites W2126266722 @default.
• W2946630268 cites W2126790027 @default.
• W2946630268 cites W2127184242 @default.
• W2946630268 cites W2127401341 @default.
• W2946630268 cites W2136790664 @default.
• W2946630268 cites W2142296653 @default.
• W2946630268 cites W2143169644 @default.
• W2946630268 cites W2144327104 @default.
• W2946630268 cites W2154895384 @default.
• W2946630268 cites W2159869836 @default.
• W2946630268 cites W2252804625 @default.
• W2946630268 cites W2267503251 @default.
• W2946630268 cites W2314129678 @default.
• W2946630268 cites W2341478304 @default.
• W2946630268 cites W2343539326 @default.
• W2946630268 cites W2525079554 @default.
• W2946630268 cites W2540172184 @default.
• W2946630268 cites W2626725576 @default.
• W2946630268 cites W2756245964 @default.
• W2946630268 cites W2807797136 @default.
• W2946630268 cites W2888378829 @default.
• W2946630268 cites W43521330 @default.
• W2946630268 cites W600697628 @default.
• W2946630268 cites W807610213 @default.
• W2946630268 doi "https://doi.org/10.1152/ajpheart.00124.2019" @default.
• W2946630268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6732486" @default.
• W2946630268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31125261" @default.
• W2946630268 hasPublicationYear "2019" @default.
• W2946630268 type Work @default.
• W2946630268 sameAs 2946630268 @default.
• W2946630268 citedByCount "12" @default.
• W2946630268 countsByYear W29466302682019 @default.
• W2946630268 countsByYear W29466302682020 @default.
• W2946630268 countsByYear W29466302682021 @default.
• W2946630268 countsByYear W29466302682022 @default.
• W2946630268 countsByYear W29466302682023 @default.
• W2946630268 crossrefType "journal-article" @default.
• W2946630268 hasAuthorship W2946630268A5006467882 @default.
• W2946630268 hasAuthorship W2946630268A5006852480 @default.
• W2946630268 hasAuthorship W2946630268A5041664116 @default.
• W2946630268 hasAuthorship W2946630268A5058617556 @default.
• W2946630268 hasAuthorship W2946630268A5080813480 @default.
• W2946630268 hasBestOaLocation W29466302681 @default.
• W2946630268 hasConcept C126322002 @default.
• W2946630268 hasConcept C164705383 @default.
• W2946630268 hasConcept C207200792 @default.
• W2946630268 hasConcept C2776820930 @default.
• W2946630268 hasConcept C2778198053 @default.
• W2946630268 hasConcept C2779537366 @default.
• W2946630268 hasConcept C2780387585 @default.
• W2946630268 hasConcept C500558357 @default.
• W2946630268 hasConcept C71924100 @default.
• W2946630268 hasConcept C78085059 @default.
• W2946630268 hasConceptScore W2946630268C126322002 @default.
• W2946630268 hasConceptScore W2946630268C164705383 @default.
• W2946630268 hasConceptScore W2946630268C207200792 @default.
• W2946630268 hasConceptScore W2946630268C2776820930 @default.
• W2946630268 hasConceptScore W2946630268C2778198053 @default.
• W2946630268 hasConceptScore W2946630268C2779537366 @default.
• W2946630268 hasConceptScore W2946630268C2780387585 @default.
• W2946630268 hasConceptScore W2946630268C500558357 @default.
• W2946630268 hasConceptScore W2946630268C71924100 @default.
• W2946630268 hasConceptScore W2946630268C78085059 @default.
• W2946630268 hasFunder F4320308035 @default.
• W2946630268 hasFunder F4320337338 @default.
• W2946630268 hasIssue "2" @default.
• W2946630268 hasLocation W29466302681 @default.
• W2946630268 hasLocation W29466302682 @default.
• W2946630268 hasLocation W29466302683 @default.
• W2946630268 hasOpenAccess W2946630268 @default.

• next