Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946642143> ?p ?o ?g. }
- W2946642143 endingPage "117955811984800" @default.
- W2946642143 startingPage "117955811984800" @default.
- W2946642143 abstract "Historically, approaches designed to offer women diagnosed with cancer the prospects of having a genetically matched child after completion of their cytotoxic treatments focused on the existing oocyte population as the sole resource available for clinical management of infertility. In this regard, elective oocyte and embryo cryopreservation, as well as autologous ovarian cortical tissue grafting posttreatment, have gained widespread support as options for young girls and reproductive-age women who are faced with cancer to consider. In addition, the use of ovarian protective therapies, including gonadotropin-releasing hormone agonists and sphingosine-1-phosphate analogs, has been put forth as an alternative way to preserve fertility by shielding existing oocytes in the ovaries in vivo from the side-effect damage caused by radiotherapy and many chemotherapeutic regimens. This viewpoint changed with the publication of now numerous reports that adult ovaries of many mammalian species, including humans, contain a rare population of oocyte-producing germ cells—referred to as female germline or oogonial stem cells (OSCs). This new line of study has fueled research into the prospects of generating new oocytes, rather than working with existing oocytes, as a novel approach to sustain or restore fertility in female cancer survivors. Here, we overview the history of work from laboratories around the world focused on improving our understanding of the biology of OSCs and how these cells may be used to reconstitute “artificial” ovarian tissue in vitro or to regenerate damaged ovarian tissue in vivo as future fertility-preservation options." @default.
- W2946642143 created "2019-05-29" @default.
- W2946642143 creator A5000058395 @default.
- W2946642143 creator A5006501583 @default.
- W2946642143 creator A5034797093 @default.
- W2946642143 date "2019-01-01" @default.
- W2946642143 modified "2023-10-18" @default.
- W2946642143 title "Female Fertility Preservation through Stem Cell-based Ovarian Tissue Reconstitution In Vitro and Ovarian Regeneration In Vivo" @default.
- W2946642143 cites W1505126425 @default.
- W2946642143 cites W1517901808 @default.
- W2946642143 cites W1570743730 @default.
- W2946642143 cites W1653876269 @default.
- W2946642143 cites W1817170190 @default.
- W2946642143 cites W1842132282 @default.
- W2946642143 cites W1868128271 @default.
- W2946642143 cites W18843369 @default.
- W2946642143 cites W1954821535 @default.
- W2946642143 cites W1967770302 @default.
- W2946642143 cites W1976929488 @default.
- W2946642143 cites W1977135603 @default.
- W2946642143 cites W1979294307 @default.
- W2946642143 cites W1981531462 @default.
- W2946642143 cites W1981932258 @default.
- W2946642143 cites W1988643971 @default.
- W2946642143 cites W1989993768 @default.
- W2946642143 cites W1991238536 @default.
- W2946642143 cites W1991843126 @default.
- W2946642143 cites W1993519794 @default.
- W2946642143 cites W1995864089 @default.
- W2946642143 cites W1998574848 @default.
- W2946642143 cites W1999758125 @default.
- W2946642143 cites W2006368059 @default.
- W2946642143 cites W2009930978 @default.
- W2946642143 cites W2010303851 @default.
- W2946642143 cites W2012924107 @default.
- W2946642143 cites W2014880952 @default.
- W2946642143 cites W2016757014 @default.
- W2946642143 cites W2016789158 @default.
- W2946642143 cites W2021971921 @default.
- W2946642143 cites W2022287786 @default.
- W2946642143 cites W2023277103 @default.
- W2946642143 cites W2029555862 @default.
- W2946642143 cites W2031942208 @default.
- W2946642143 cites W2032034787 @default.
- W2946642143 cites W2035437353 @default.
- W2946642143 cites W2037977021 @default.
- W2946642143 cites W2041288808 @default.
- W2946642143 cites W2042272294 @default.
- W2946642143 cites W2043822973 @default.
- W2946642143 cites W2047247552 @default.
- W2946642143 cites W2048769612 @default.
- W2946642143 cites W2049348481 @default.
- W2946642143 cites W2050036034 @default.
- W2946642143 cites W2053062054 @default.
- W2946642143 cites W2057052045 @default.
- W2946642143 cites W2057836896 @default.
- W2946642143 cites W2060702385 @default.
- W2946642143 cites W2068469659 @default.
- W2946642143 cites W2071421991 @default.
- W2946642143 cites W2086638852 @default.
- W2946642143 cites W2088996917 @default.
- W2946642143 cites W2091171281 @default.
- W2946642143 cites W2098553876 @default.
- W2946642143 cites W2099615704 @default.
- W2946642143 cites W2100910995 @default.
- W2946642143 cites W2101259834 @default.
- W2946642143 cites W2105559667 @default.
- W2946642143 cites W2106594032 @default.
- W2946642143 cites W2107652116 @default.
- W2946642143 cites W2109166024 @default.
- W2946642143 cites W2111821999 @default.
- W2946642143 cites W2112844484 @default.
- W2946642143 cites W2115183068 @default.
- W2946642143 cites W2117590220 @default.
- W2946642143 cites W2117878780 @default.
- W2946642143 cites W2118722608 @default.
- W2946642143 cites W2118946046 @default.
- W2946642143 cites W2120661245 @default.
- W2946642143 cites W2121903033 @default.
- W2946642143 cites W2123075417 @default.
- W2946642143 cites W2125980548 @default.
- W2946642143 cites W2128780026 @default.
- W2946642143 cites W2129965634 @default.
- W2946642143 cites W2130191551 @default.
- W2946642143 cites W2135400390 @default.
- W2946642143 cites W2138424768 @default.
- W2946642143 cites W2139275344 @default.
- W2946642143 cites W2139946475 @default.
- W2946642143 cites W2140861147 @default.
- W2946642143 cites W2140919995 @default.
- W2946642143 cites W2143608188 @default.
- W2946642143 cites W2144504411 @default.
- W2946642143 cites W2148756505 @default.
- W2946642143 cites W2150921965 @default.
- W2946642143 cites W2151686920 @default.
- W2946642143 cites W2153820217 @default.
- W2946642143 cites W2155277570 @default.
- W2946642143 cites W2160715479 @default.