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- W2946642721 endingPage "631" @default.
- W2946642721 startingPage "623" @default.
- W2946642721 abstract "Introduction: Liver disease is an increasing cause of worldwide mortality, and currently the only curative treatment for end-stage liver disease is whole organ allograft transplantation. Whilst this is an effective treatment, there is a shortage of suitable grafts and consequently some patients die whilst on the waiting list. Cell therapy provides an alternative treatment to increase liver function and potentially ameliorate fibrosis.Areas covered: In this review, we discuss the different cellular sources for therapy investigated to date in humans including mature hepatocytes, hematopoietic stem cells, mesenchymal stromal cells and hepatic progenitor cells. Cells investigated in animals include embryonic stem cells, induced pluripotent stem cells and directly reprogrammed cells. We then appraise the experience and evidence base underlying each cell type.Expert opinion: We discuss how this field may evolve in the years to come focusing on opportunities to enhance the intrinsic regenerative response with therapeutic targets and cell therapies. Growing expertise in tissue engineering will likely lead to increasingly complex bio-reactors and bio-artificial livers, which open a further avenue to restore liver function and delay or prevent the need for transplantation." @default.
- W2946642721 created "2019-05-29" @default.
- W2946642721 creator A5019878734 @default.
- W2946642721 creator A5044832887 @default.
- W2946642721 creator A5045224853 @default.
- W2946642721 date "2019-05-20" @default.
- W2946642721 modified "2023-09-24" @default.
- W2946642721 title "The role of stem cells in liver injury and repair" @default.
- W2946642721 cites W1061628335 @default.
- W2946642721 cites W126539919 @default.
- W2946642721 cites W1568300712 @default.
- W2946642721 cites W1841268200 @default.
- W2946642721 cites W1842800599 @default.
- W2946642721 cites W1967347732 @default.
- W2946642721 cites W1967703106 @default.
- W2946642721 cites W1969832663 @default.
- W2946642721 cites W1971237796 @default.
- W2946642721 cites W1984097721 @default.
- W2946642721 cites W1984582197 @default.
- W2946642721 cites W1985605815 @default.
- W2946642721 cites W1985932431 @default.
- W2946642721 cites W1986826310 @default.
- W2946642721 cites W1988627175 @default.
- W2946642721 cites W1989749181 @default.
- W2946642721 cites W1998666537 @default.
- W2946642721 cites W2000151960 @default.
- W2946642721 cites W2001213911 @default.
- W2946642721 cites W2003338481 @default.
- W2946642721 cites W2005176562 @default.
- W2946642721 cites W2008285918 @default.
- W2946642721 cites W2008365696 @default.
- W2946642721 cites W2009222736 @default.
- W2946642721 cites W2011653132 @default.
- W2946642721 cites W2020886306 @default.
- W2946642721 cites W2023821363 @default.
- W2946642721 cites W2025371271 @default.
- W2946642721 cites W2025966264 @default.
- W2946642721 cites W2030077110 @default.
- W2946642721 cites W2034004034 @default.
- W2946642721 cites W2041390659 @default.
- W2946642721 cites W2042487476 @default.
- W2946642721 cites W2045574035 @default.
- W2946642721 cites W2053187437 @default.
- W2946642721 cites W2056510085 @default.
- W2946642721 cites W2060162935 @default.
- W2946642721 cites W2061644566 @default.
- W2946642721 cites W2065412622 @default.
- W2946642721 cites W2066949938 @default.
- W2946642721 cites W2072899346 @default.
- W2946642721 cites W2073910979 @default.
- W2946642721 cites W2074510758 @default.
- W2946642721 cites W2075348465 @default.
- W2946642721 cites W2081968631 @default.
- W2946642721 cites W2082343955 @default.
- W2946642721 cites W2084074847 @default.
- W2946642721 cites W2085652695 @default.
- W2946642721 cites W2086943348 @default.
- W2946642721 cites W2087353148 @default.
- W2946642721 cites W2089154676 @default.
- W2946642721 cites W2094243584 @default.
- W2946642721 cites W2099676796 @default.
- W2946642721 cites W2102869463 @default.
- W2946642721 cites W2103784616 @default.
- W2946642721 cites W2104116192 @default.
- W2946642721 cites W2115268377 @default.
- W2946642721 cites W2132328659 @default.
- W2946642721 cites W2132610571 @default.
- W2946642721 cites W2148173491 @default.
- W2946642721 cites W2148727945 @default.
- W2946642721 cites W2148913003 @default.
- W2946642721 cites W2150110701 @default.
- W2946642721 cites W2150248371 @default.
- W2946642721 cites W2155942576 @default.
- W2946642721 cites W2158093070 @default.
- W2946642721 cites W2159999899 @default.
- W2946642721 cites W2164829386 @default.
- W2946642721 cites W2175513134 @default.
- W2946642721 cites W2190678000 @default.
- W2946642721 cites W2273947099 @default.
- W2946642721 cites W2298033154 @default.
- W2946642721 cites W2324489891 @default.
- W2946642721 cites W2339783570 @default.
- W2946642721 cites W2511331749 @default.
- W2946642721 cites W2587571866 @default.
- W2946642721 cites W2593844681 @default.
- W2946642721 cites W2598770210 @default.
- W2946642721 cites W2601350462 @default.
- W2946642721 cites W2626531388 @default.
- W2946642721 cites W2743167126 @default.
- W2946642721 cites W2767699210 @default.
- W2946642721 cites W2769010773 @default.
- W2946642721 cites W2769783686 @default.
- W2946642721 cites W2782051792 @default.
- W2946642721 cites W2782460017 @default.
- W2946642721 cites W2789450435 @default.
- W2946642721 cites W2803506304 @default.
- W2946642721 cites W2808974142 @default.
- W2946642721 cites W2892245481 @default.