Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946656283> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2946656283 abstract "Background. Pathological causes of acne and hirsutism include polycystic ovarian syndrome (PCOS), congenital adrenal hyperplasia, and adrenal or ovarian tumors. PCOS is largely a clinical diagnosis and often simple laboratory testing can rule out more severe pathology. In more severe cases, determination of the correct diagnosis can require hormone suppression testing. In this article, we present a full sequence of hormone suppression testing and workup necessary to arrive at the ultimate diagnosis. Case Presentation. A 12-year-old normal weight (body mass index = 29th percentile), premenarchal female with Tanner III breast, Tanner V pubic hair presented with a 2.5-year history of severe hirsutism (Ferriman-Gallwey Score of 22), clitoromegaly, and deep voice. Successive hormone suppression and testing (ACTH stimulation testing, ovarian and adrenal imaging, dexamethasone-suppressed ACTH stimulation testing, and oral contraceptive therapy) was necessary to rule out congenital adrenal hyperplasia or a tumor and confirm PCOS. Metabolic testing, completed only after diagnosing PCOS, demonstrated insulin resistance. Conclusions. This patient had an extreme presentation of a common disorder. Her premenarchal status, elevated androgens, and virilization raised concern for non-PCOS pathology requiring sequential pharmacological hormone suppression testing and imaging for accurate diagnosis and appropriate treatment. The testing presented here is not novel, but we present the full sequence of testing and clinical results. This full sequence is rarely necessary for accurate diagnosis given clinical presentation and initial evaluation and, therefore, to our knowledge, has not been published. All providers caring for patients with PCOS should be familiar with this testing and its interpretation for severe cases that warrant extra attention." @default.
- W2946656283 created "2019-05-29" @default.
- W2946656283 creator A5007539245 @default.
- W2946656283 creator A5013267424 @default.
- W2946656283 date "2019-01-01" @default.
- W2946656283 modified "2023-10-17" @default.
- W2946656283 title "Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report" @default.
- W2946656283 cites W1794483082 @default.
- W2946656283 cites W2002926240 @default.
- W2946656283 cites W2029059844 @default.
- W2946656283 cites W2097951074 @default.
- W2946656283 cites W2108765410 @default.
- W2946656283 cites W2124821102 @default.
- W2946656283 cites W2157576636 @default.
- W2946656283 cites W2171845134 @default.
- W2946656283 cites W2334254512 @default.
- W2946656283 cites W2548439163 @default.
- W2946656283 cites W2621206961 @default.
- W2946656283 doi "https://doi.org/10.1177/2324709619850215" @default.
- W2946656283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6537283" @default.
- W2946656283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31113263" @default.
- W2946656283 hasPublicationYear "2019" @default.
- W2946656283 type Work @default.
- W2946656283 sameAs 2946656283 @default.
- W2946656283 citedByCount "0" @default.
- W2946656283 crossrefType "journal-article" @default.
- W2946656283 hasAuthorship W2946656283A5007539245 @default.
- W2946656283 hasAuthorship W2946656283A5013267424 @default.
- W2946656283 hasBestOaLocation W29466562831 @default.
- W2946656283 hasConcept C126322002 @default.
- W2946656283 hasConcept C2776371013 @default.
- W2946656283 hasConcept C2776631543 @default.
- W2946656283 hasConcept C2777391703 @default.
- W2946656283 hasConcept C2777767042 @default.
- W2946656283 hasConcept C2777911890 @default.
- W2946656283 hasConcept C2779306644 @default.
- W2946656283 hasConcept C2780401358 @default.
- W2946656283 hasConcept C2780455818 @default.
- W2946656283 hasConcept C29456083 @default.
- W2946656283 hasConcept C3018442814 @default.
- W2946656283 hasConcept C71315377 @default.
- W2946656283 hasConcept C71924100 @default.
- W2946656283 hasConceptScore W2946656283C126322002 @default.
- W2946656283 hasConceptScore W2946656283C2776371013 @default.
- W2946656283 hasConceptScore W2946656283C2776631543 @default.
- W2946656283 hasConceptScore W2946656283C2777391703 @default.
- W2946656283 hasConceptScore W2946656283C2777767042 @default.
- W2946656283 hasConceptScore W2946656283C2777911890 @default.
- W2946656283 hasConceptScore W2946656283C2779306644 @default.
- W2946656283 hasConceptScore W2946656283C2780401358 @default.
- W2946656283 hasConceptScore W2946656283C2780455818 @default.
- W2946656283 hasConceptScore W2946656283C29456083 @default.
- W2946656283 hasConceptScore W2946656283C3018442814 @default.
- W2946656283 hasConceptScore W2946656283C71315377 @default.
- W2946656283 hasConceptScore W2946656283C71924100 @default.
- W2946656283 hasFunder F4320337357 @default.
- W2946656283 hasLocation W29466562831 @default.
- W2946656283 hasLocation W29466562832 @default.
- W2946656283 hasLocation W29466562833 @default.
- W2946656283 hasLocation W29466562834 @default.
- W2946656283 hasOpenAccess W2946656283 @default.
- W2946656283 hasPrimaryLocation W29466562831 @default.
- W2946656283 hasRelatedWork W125131764 @default.
- W2946656283 hasRelatedWork W159568488 @default.
- W2946656283 hasRelatedWork W2063082610 @default.
- W2946656283 hasRelatedWork W2171845134 @default.
- W2946656283 hasRelatedWork W2317415297 @default.
- W2946656283 hasRelatedWork W2396515219 @default.
- W2946656283 hasRelatedWork W2441485180 @default.
- W2946656283 hasRelatedWork W2946656283 @default.
- W2946656283 hasRelatedWork W4220958713 @default.
- W2946656283 hasRelatedWork W4236392405 @default.
- W2946656283 isParatext "false" @default.
- W2946656283 isRetracted "false" @default.
- W2946656283 magId "2946656283" @default.
- W2946656283 workType "article" @default.