FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946681631> ?p ?o ?g. }

• W2946681631 endingPage "1045" @default.
• W2946681631 startingPage "1033" @default.
• W2946681631 abstract "Limb girdle muscular dystrophy type R9 (LGMD R9) is an autosomal recessive muscle disease for which there is currently no causative treatment. The development of putative therapies requires sensitive outcome measures for clinical trials in this slowly progressing condition. This study extends functional assessments and MRI muscle fat fraction measurements in an LGMD R9 cohort across 6 years.Twenty-three participants with LGMD R9, previously assessed over a 1-year period, were re-enrolled at 6 years. Standardized functional assessments were performed including: myometry, timed tests, and spirometry testing. Quantitative MRI was used to measure fat fraction in lower limb skeletal muscle groups.At 6 years, all 14 muscle groups assessed demonstrated significant increases in fat fraction, compared to eight groups in the 1-year follow-up study. In direct contrast to the 1-year follow-up, the 6-min walk test, 10-m walk or run, timed up and go, stair ascend, stair descend and chair rise demonstrated significant decline. Among the functional tests, only FVC significantly declined over both the 1- and 6-year studies.These results further support fat fraction measurements as a primary outcome measure alongside functional assessments. The most appropriate individual muscles are the vastus lateralis, gracilis, sartorius, and gastrocnemii. Using composite groups of lower leg muscles, thigh muscles, or triceps surae, yielded high standardized response means (SRMs). Over 6 years, quantitative fat fraction assessment demonstrated higher SRM values than seen in functional tests suggesting greater responsiveness to disease progression." @default.
• W2946681631 created "2019-05-29" @default.
• W2946681631 creator A5003254789 @default.
• W2946681631 creator A5004880821 @default.
• W2946681631 creator A5006189680 @default.
• W2946681631 creator A5009171206 @default.
• W2946681631 creator A5009739717 @default.
• W2946681631 creator A5009837921 @default.
• W2946681631 creator A5018913953 @default.
• W2946681631 creator A5023248855 @default.
• W2946681631 creator A5026509971 @default.
• W2946681631 creator A5038636561 @default.
• W2946681631 creator A5044962245 @default.
• W2946681631 creator A5062027123 @default.
• W2946681631 creator A5063662661 @default.
• W2946681631 creator A5069635447 @default.
• W2946681631 creator A5075086360 @default.
• W2946681631 creator A5075931186 @default.
• W2946681631 creator A5078093755 @default.
• W2946681631 creator A5083676325 @default.
• W2946681631 creator A5084624493 @default.
• W2946681631 date "2019-05-16" @default.
• W2946681631 modified "2023-10-06" @default.
• W2946681631 title "Natural history of limb girdle muscular dystrophy R9 over 6 years: searching for trial endpoints" @default.
• W2946681631 cites W1524530894 @default.
• W2946681631 cites W1627412353 @default.
• W2946681631 cites W1935523855 @default.
• W2946681631 cites W1968990159 @default.
• W2946681631 cites W1974704788 @default.
• W2946681631 cites W1975139695 @default.
• W2946681631 cites W1998005699 @default.
• W2946681631 cites W2001604199 @default.
• W2946681631 cites W2004867621 @default.
• W2946681631 cites W2013181244 @default.
• W2946681631 cites W2020685420 @default.
• W2946681631 cites W2025669016 @default.
• W2946681631 cites W2026084370 @default.
• W2946681631 cites W2049669109 @default.
• W2946681631 cites W2063235898 @default.
• W2946681631 cites W2063623639 @default.
• W2946681631 cites W2064755736 @default.
• W2946681631 cites W2066125032 @default.
• W2946681631 cites W2084703547 @default.
• W2946681631 cites W2091034493 @default.
• W2946681631 cites W2114242035 @default.
• W2946681631 cites W2125293681 @default.
• W2946681631 cites W2130884450 @default.
• W2946681631 cites W2137339327 @default.
• W2946681631 cites W2155680950 @default.
• W2946681631 cites W2277280343 @default.
• W2946681631 cites W2333684696 @default.
• W2946681631 cites W2342721004 @default.
• W2946681631 cites W2501089689 @default.
• W2946681631 cites W2514992329 @default.
• W2946681631 cites W2516903012 @default.
• W2946681631 cites W2522240791 @default.
• W2946681631 cites W2534318947 @default.
• W2946681631 cites W2587334886 @default.
• W2946681631 cites W2724098443 @default.
• W2946681631 cites W2803489227 @default.
• W2946681631 cites W4245666729 @default.
• W2946681631 doi "https://doi.org/10.1002/acn3.774" @default.
• W2946681631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6562036" @default.
• W2946681631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31211167" @default.
• W2946681631 hasPublicationYear "2019" @default.
• W2946681631 type Work @default.
• W2946681631 sameAs 2946681631 @default.
• W2946681631 citedByCount "18" @default.
• W2946681631 countsByYear W29466816312019 @default.
• W2946681631 countsByYear W29466816312020 @default.
• W2946681631 countsByYear W29466816312021 @default.
• W2946681631 countsByYear W29466816312022 @default.
• W2946681631 countsByYear W29466816312023 @default.
• W2946681631 crossrefType "journal-article" @default.
• W2946681631 hasAuthorship W2946681631A5003254789 @default.
• W2946681631 hasAuthorship W2946681631A5004880821 @default.
• W2946681631 hasAuthorship W2946681631A5006189680 @default.
• W2946681631 hasAuthorship W2946681631A5009171206 @default.
• W2946681631 hasAuthorship W2946681631A5009739717 @default.
• W2946681631 hasAuthorship W2946681631A5009837921 @default.
• W2946681631 hasAuthorship W2946681631A5018913953 @default.
• W2946681631 hasAuthorship W2946681631A5023248855 @default.
• W2946681631 hasAuthorship W2946681631A5026509971 @default.
• W2946681631 hasAuthorship W2946681631A5038636561 @default.
• W2946681631 hasAuthorship W2946681631A5044962245 @default.
• W2946681631 hasAuthorship W2946681631A5062027123 @default.
• W2946681631 hasAuthorship W2946681631A5063662661 @default.
• W2946681631 hasAuthorship W2946681631A5069635447 @default.
• W2946681631 hasAuthorship W2946681631A5075086360 @default.
• W2946681631 hasAuthorship W2946681631A5075931186 @default.
• W2946681631 hasAuthorship W2946681631A5078093755 @default.
• W2946681631 hasAuthorship W2946681631A5083676325 @default.
• W2946681631 hasAuthorship W2946681631A5084624493 @default.
• W2946681631 hasBestOaLocation W29466816311 @default.
• W2946681631 hasConcept C104317684 @default.
• W2946681631 hasConcept C126322002 @default.
• W2946681631 hasConcept C127716648 @default.
• W2946681631 hasConcept C141071460 @default.

• next