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• W2946682191 endingPage "448" @default.
• W2946682191 startingPage "437" @default.
• W2946682191 abstract "O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus, cytoplasm, and mitochondria. The donor sugar for O-GlcNAcylation, uridine-diphosphate N-acetylglucosamine (UDP-GlcNAc), is synthesized from glucose through the hexosamine biosynthetic pathway (HBP). The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which catalyze the addition and removal of O-GlcNAc, respectively. O-GlcNAcylation is involved in a number of important cell processes including transcription, translation, metabolism, signal transduction, and apoptosis. Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer, diabetes, neurodegenerative diseases, and cardiovascular diseases. A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic intervention. The aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases, and its potential as a new clinical target." @default.
• W2946682191 created "2019-05-29" @default.
• W2946682191 creator A5024835172 @default.
• W2946682191 creator A5025244888 @default.
• W2946682191 date "2019-05-01" @default.
• W2946682191 modified "2023-10-16" @default.
• W2946682191 title "O-GlcNAcylation, a sweet link to the pathology of diseases" @default.
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• W2946682191 cites W1968005873 @default.
• W2946682191 cites W1969435874 @default.
• W2946682191 cites W1969575348 @default.
• W2946682191 cites W1974906557 @default.
• W2946682191 cites W1979095700 @default.
• W2946682191 cites W1981809260 @default.
• W2946682191 cites W1989476631 @default.
• W2946682191 cites W1990634680 @default.
• W2946682191 cites W2004373930 @default.
• W2946682191 cites W2009779581 @default.
• W2946682191 cites W2022396367 @default.
• W2946682191 cites W2022647011 @default.
• W2946682191 cites W2025748859 @default.
• W2946682191 cites W2035020831 @default.
• W2946682191 cites W2035837644 @default.
• W2946682191 cites W2035873080 @default.
• W2946682191 cites W2053531649 @default.
• W2946682191 cites W2054664745 @default.
• W2946682191 cites W2056711756 @default.
• W2946682191 cites W2057417666 @default.
• W2946682191 cites W2060744329 @default.
• W2946682191 cites W2060799932 @default.
• W2946682191 cites W2061882997 @default.
• W2946682191 cites W2070417148 @default.
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• W2946682191 cites W2079513743 @default.
• W2946682191 cites W2094005996 @default.
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• W2946682191 cites W2154885060 @default.
• W2946682191 cites W2158953193 @default.
• W2946682191 cites W2169486515 @default.
• W2946682191 cites W2170781810 @default.
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• W2946682191 doi "https://doi.org/10.1631/jzus.b1900150" @default.
• W2946682191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6568225" @default.
• W2946682191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31090269" @default.
• W2946682191 hasPublicationYear "2019" @default.
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