FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946703187> ?p ?o ?g. }

• W2946703187 abstract "Current antifungal drugs present poor effectiveness and there is no available vaccine for fungal infections. Thus, novel strategies to treat or prevent invasive mycosis, such as cryptococcosis, are highly desirable. One strategy is the use of immunomodulators of polysaccharide nature isolated from mushrooms. The purpose of the present work was to evaluate the immunostimulatory activity of β-(1,3)-glucan-containing exopolysaccharides (EPS) from the edible mushrooms Auricularia auricula in phagocytes and mice infected with Cryptococcus neoformans. EPS triggered macrophages and dendritic cell activation upon binding to Dectin-1, a pattern recognition receptor of the C-type lectin receptor family. Engagement of Dectin-1 culminated in pro-inflammatory cytokine production and cell maturation via its canonical Syk-dependent pathway signaling. Furthermore, upon EPS treatment, M2-like phenotype macrophages, known to support intracellular survival and replication of C. neoformans, repolarize to M1 macrophage pattern associated with enhanced production of the microbicidal molecule nitric oxide that results in efficient killing of C. neoformans. Treatment with EPS also upregulated transcript levels of genes encoding products associated with host protection against C. neoformans and Dectin-1 mediated signaling in macrophages. Finally, orally administrated β-glucan-containing EPS from A. auricular enhanced the survival of mice infected with C. neoformans. In conclusion, the results demonstrate that EPS from A. auricula exert immunostimulatory activity in phagocytes and induce host protection against C. neoformans, suggesting that polysaccharides from this mushroom may be promising as an adjuvant for vaccines or antifungal therapy." @default.
• W2946703187 created "2019-05-29" @default.
• W2946703187 creator A5001653179 @default.
• W2946703187 creator A5004354210 @default.
• W2946703187 creator A5018371546 @default.
• W2946703187 creator A5024598882 @default.
• W2946703187 creator A5028124257 @default.
• W2946703187 creator A5032228669 @default.
• W2946703187 creator A5041503930 @default.
• W2946703187 creator A5050211440 @default.
• W2946703187 creator A5061405111 @default.
• W2946703187 creator A5067148501 @default.
• W2946703187 creator A5088853063 @default.
• W2946703187 date "2019-05-16" @default.
• W2946703187 modified "2023-10-15" @default.
• W2946703187 title "Immunomodulatory activity of β-glucan-containing exopolysaccharides from Auricularia auricular in phagocytes and mice infected with Cryptococcus neoformans" @default.
• W2946703187 cites W1537864866 @default.
• W2946703187 cites W1771132803 @default.
• W2946703187 cites W1789843860 @default.
• W2946703187 cites W1806823535 @default.
• W2946703187 cites W1893049000 @default.
• W2946703187 cites W1907437706 @default.
• W2946703187 cites W1942388905 @default.
• W2946703187 cites W1965390387 @default.
• W2946703187 cites W1975088467 @default.
• W2946703187 cites W2004336750 @default.
• W2946703187 cites W2019428230 @default.
• W2946703187 cites W2026720658 @default.
• W2946703187 cites W2032103467 @default.
• W2946703187 cites W2040004606 @default.
• W2946703187 cites W2040386323 @default.
• W2946703187 cites W2043474036 @default.
• W2946703187 cites W2044806499 @default.
• W2946703187 cites W2052554412 @default.
• W2946703187 cites W2060615771 @default.
• W2946703187 cites W2061682743 @default.
• W2946703187 cites W2062406170 @default.
• W2946703187 cites W2069149129 @default.
• W2946703187 cites W2072828023 @default.
• W2946703187 cites W2092235636 @default.
• W2946703187 cites W2094224269 @default.
• W2946703187 cites W2095433946 @default.
• W2946703187 cites W2098511533 @default.
• W2946703187 cites W2098966232 @default.
• W2946703187 cites W2099845332 @default.
• W2946703187 cites W2107277218 @default.
• W2946703187 cites W2109282547 @default.
• W2946703187 cites W2114424988 @default.
• W2946703187 cites W2119252911 @default.
• W2946703187 cites W2123303185 @default.
• W2946703187 cites W2123941872 @default.
• W2946703187 cites W2125105493 @default.
• W2946703187 cites W2127424425 @default.
• W2946703187 cites W2131741092 @default.
• W2946703187 cites W2140333814 @default.
• W2946703187 cites W2141305069 @default.
• W2946703187 cites W2146171603 @default.
• W2946703187 cites W2146525666 @default.
• W2946703187 cites W2151626638 @default.
• W2946703187 cites W2153548587 @default.
• W2946703187 cites W2158373279 @default.
• W2946703187 cites W2164205696 @default.
• W2946703187 cites W2166123227 @default.
• W2946703187 cites W2167830630 @default.
• W2946703187 cites W2173068170 @default.
• W2946703187 cites W2219979778 @default.
• W2946703187 cites W2314247642 @default.
• W2946703187 cites W2491394662 @default.
• W2946703187 cites W2593309210 @default.
• W2946703187 cites W2609328715 @default.
• W2946703187 cites W2611697423 @default.
• W2946703187 cites W2625503843 @default.
• W2946703187 cites W2762139220 @default.
• W2946703187 cites W2768821520 @default.
• W2946703187 cites W2798012374 @default.
• W2946703187 cites W2800541053 @default.
• W2946703187 cites W2808310753 @default.
• W2946703187 cites W4292266514 @default.
• W2946703187 doi "https://doi.org/10.1093/mmy/myz042" @default.
• W2946703187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31095342" @default.
• W2946703187 hasPublicationYear "2019" @default.
• W2946703187 type Work @default.
• W2946703187 sameAs 2946703187 @default.
• W2946703187 citedByCount "10" @default.
• W2946703187 countsByYear W29467031872019 @default.
• W2946703187 countsByYear W29467031872020 @default.
• W2946703187 countsByYear W29467031872021 @default.
• W2946703187 countsByYear W29467031872022 @default.
• W2946703187 countsByYear W29467031872023 @default.
• W2946703187 crossrefType "journal-article" @default.
• W2946703187 hasAuthorship W2946703187A5001653179 @default.
• W2946703187 hasAuthorship W2946703187A5004354210 @default.
• W2946703187 hasAuthorship W2946703187A5018371546 @default.
• W2946703187 hasAuthorship W2946703187A5024598882 @default.
• W2946703187 hasAuthorship W2946703187A5028124257 @default.
• W2946703187 hasAuthorship W2946703187A5032228669 @default.
• W2946703187 hasAuthorship W2946703187A5041503930 @default.
• W2946703187 hasAuthorship W2946703187A5050211440 @default.
• W2946703187 hasAuthorship W2946703187A5061405111 @default.
• W2946703187 hasAuthorship W2946703187A5067148501 @default.

• next