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• W2946752610 endingPage "1953" @default.
• W2946752610 startingPage "1946" @default.
• W2946752610 abstract "Minidumbbell (MDB) is a newly found non-B DNA structure formed by short single-strand sequences. Up to now, three MDBs have been reported to form at neutral pH by sequences containing two repeats of TTTA, CCTG and CTTG. Among them, the thermodynamically less stable TTTA and CCTG MDBs have been proposed to be the structural intermediates that cause TTTA and CCTG repeat expansions during DNA replication in Staphylococcus aureus pathogen and myotonic dystrophy type 2 patients, respectively. Although the CTTG MDB has a melting temperature of at least 13 °C higher than those of the other two, no CTTG repeat expansion has ever been reported in any genomes. In this study, we successfully determined the solution structure of the CTTG MDB and observed for the first time the formation of a reverse wobble T·T mispair with two symmetric hydrogen bonds. More importantly, we identified unprecedented hydrophobic interactions between the two methyl groups of this T·T mispair and the four 2′-methylene groups of their nearby loop-closing base pair residues. These stabilizations account for the substantial increase in the MDB thermodynamic stability which may govern the occurrence of repeat expansions.Communicated by Ramaswamy H. Sarma" @default.
• W2946752610 created "2019-05-29" @default.
• W2946752610 creator A5000891199 @default.
• W2946752610 creator A5039848145 @default.
• W2946752610 date "2019-05-30" @default.
• W2946752610 modified "2023-09-26" @default.
• W2946752610 title "Unprecedented hydrophobic stabilizations from a reverse wobble T·T mispair in DNA minidumbbell" @default.
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• W2946752610 doi "https://doi.org/10.1080/07391102.2019.1621211" @default.
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