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- W2946758800 abstract "A Balz-Schiemann reaction was developed to convert 2-cyano-5-aminopyridine to 2-cyano-5-fluoropyridine. The use of an ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate, BMIMBF4) as a solvent was found to be critical in achieving high assay yields and high selectivity for the fluorination vs. protonation. A process was developed to recycle and reuse the ionic liquid enabling its cost-effective use as a solvent. Finally, the optimal conditions were demonstrated under as a continuous process to address process safety risks associated with diazonium intermediates and the product was used to access a key intermediate in the synthesis of β-amyloid cleaving enzyme 1 inhibitor, verubecestat." @default.
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- W2946758800 date "2019-08-01" @default.
- W2946758800 modified "2023-10-05" @default.
- W2946758800 title "An improved Balz-Schiemann reaction enabled by ionic liquids and continuous processing" @default.
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- W2946758800 doi "https://doi.org/10.1016/j.tet.2019.05.020" @default.
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