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- W2946760890 abstract "A prospective study was performed on 100 patients suffering from stroke (50 patients were treated with 70 USP heparin/kg b.w./12 hours sc., and Simultaneously, the other 50 patients were treated with 0.9% NaCl twice every 24 hours). The concentration of Antithrombin III (A. III conc.) was measured immunologically (Mancini-technique). The “Antithrombin activity” of the patients’ plasma was evaluated photometrically using chromogenic substrate Chromozym TH (incubation of diluted plasma with 3.5 NIH Thrombin, 5, 15 and 30 min., 37°C). In 50 of these patients (N = 100) the A.III conc. as well as the Antithrombin activity of plasma was found to be decreased, compared with the group of healthy blood donors (N = 50). In 30% of the patients A.III conc.was found to be increased while the plasma’s Antithrombin activity was significantly decreased. Normal values of A.III conc. were observed in less than 20% of the patients. A significant higher rate of deep vein thrombosis was observed in patients not receiving heparin treatment (6/45). No correlation was found between A.III conc. or heparin treatment and the severity of cerebral infarction. Also, no significant differences in A.III conc . (Mancinit technigue) were evaluated between these two groups. Significant differences between parents treated with heparin and those not treated were evaluated by the photometrical measurement of Antithrombin activity in the plasma." @default.
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- W2946760890 date "1979-01-01" @default.
- W2946760890 modified "2023-09-26" @default.
- W2946760890 title "Observations on Antithrombin-III-Concentration and its Biological Function During Low Dose Heparin Administration in Patients Suffering from Stroke" @default.
- W2946760890 doi "https://doi.org/10.1055/s-0039-1687304" @default.
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