FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946811215> ?p ?o ?g. }

• W2946811215 endingPage "1724" @default.
• W2946811215 startingPage "1706" @default.
• W2946811215 abstract "The tumor microenvironment contains various components, including cancer cells, tumor vessels, and cancer-associated fibroblasts, the latter of which are comprised of tumor-promoting myofibroblasts and tumor-suppressing fibroblasts. Multiple lines of evidence indicate that transforming growth factor-β (TGF-β) induces the formation of myofibroblasts and other types of mesenchymal (non-myofibroblastic) cells from endothelial cells. Recent reports show that fibroblast growth factor 2 (FGF2) modulates TGF-β-induced mesenchymal transition of endothelial cells, but the molecular mechanisms behind the signals that control transcriptional networks during the formation of different groups of fibroblasts remain largely unclear. Here, we studied the roles of FGF2 during the regulation of TGF-β-induced mesenchymal transition of tumor endothelial cells (TECs). We demonstrated that auto/paracrine FGF signals in TECs inhibit TGF-β-induced endothelial-to-myofibroblast transition (End-MyoT), leading to suppressed formation of contractile myofibroblast cells, but on the other hand can also collaborate with TGF-β in promoting the formation of active fibroblastic cells which have migratory and proliferative properties. FGF2 modulated TGF-β-induced formation of myofibroblastic and non-myofibroblastic cells from TECs via transcriptional regulation of various mesenchymal markers and growth factors. Furthermore, we observed that TECs treated with TGF-β were more competent in promoting in vivo tumor growth than TECs treated with TGF-β and FGF2. Mechanistically, we showed that Elk1 mediated FGF2-induced inhibition of End-MyoT via inhibition of TGF-β-induced transcriptional activation of α-smooth muscle actin promoter by myocardin-related transcription factor-A. Our data suggest that TGF-β and FGF2 oppose and cooperate with each other during the formation of myofibroblastic and non-myofibroblastic cells from TECs, which in turn determines the characteristics of mesenchymal cells in the tumor microenvironment." @default.
• W2946811215 created "2019-05-29" @default.
• W2946811215 creator A5015825703 @default.
• W2946811215 creator A5027873799 @default.
• W2946811215 creator A5039550839 @default.
• W2946811215 creator A5046087332 @default.
• W2946811215 creator A5048426787 @default.
• W2946811215 creator A5050984306 @default.
• W2946811215 creator A5051009186 @default.
• W2946811215 creator A5052170454 @default.
• W2946811215 creator A5064568192 @default.
• W2946811215 creator A5067509135 @default.
• W2946811215 creator A5077293541 @default.
• W2946811215 creator A5082105510 @default.
• W2946811215 date "2019-06-19" @default.
• W2946811215 modified "2023-10-15" @default.
• W2946811215 title "Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1" @default.
• W2946811215 cites W103541336 @default.
• W2946811215 cites W1678482413 @default.
• W2946811215 cites W1926017383 @default.
• W2946811215 cites W1966672647 @default.
• W2946811215 cites W1970393647 @default.
• W2946811215 cites W1970940391 @default.
• W2946811215 cites W1974523661 @default.
• W2946811215 cites W1975837861 @default.
• W2946811215 cites W1978084442 @default.
• W2946811215 cites W1978802056 @default.
• W2946811215 cites W1981781176 @default.
• W2946811215 cites W1982289936 @default.
• W2946811215 cites W2018011096 @default.
• W2946811215 cites W2019222060 @default.
• W2946811215 cites W2031137884 @default.
• W2946811215 cites W2037590098 @default.
• W2946811215 cites W2048326490 @default.
• W2946811215 cites W2069544366 @default.
• W2946811215 cites W2073235331 @default.
• W2946811215 cites W2074536446 @default.
• W2946811215 cites W2080435694 @default.
• W2946811215 cites W2086319262 @default.
• W2946811215 cites W2088258483 @default.
• W2946811215 cites W2092828187 @default.
• W2946811215 cites W2101037339 @default.
• W2946811215 cites W2103328690 @default.
• W2946811215 cites W2103919722 @default.
• W2946811215 cites W2106256269 @default.
• W2946811215 cites W2107105080 @default.
• W2946811215 cites W2111179262 @default.
• W2946811215 cites W2115542035 @default.
• W2946811215 cites W2116725504 @default.
• W2946811215 cites W2125089384 @default.
• W2946811215 cites W2130275173 @default.
• W2946811215 cites W2136220732 @default.
• W2946811215 cites W2137564768 @default.
• W2946811215 cites W2139602514 @default.
• W2946811215 cites W2143145016 @default.
• W2946811215 cites W2143349604 @default.
• W2946811215 cites W2154087679 @default.
• W2946811215 cites W2154632428 @default.
• W2946811215 cites W2158564701 @default.
• W2946811215 cites W2193549616 @default.
• W2946811215 cites W2279137994 @default.
• W2946811215 cites W2292869933 @default.
• W2946811215 cites W2293074557 @default.
• W2946811215 cites W2298872710 @default.
• W2946811215 cites W2440111950 @default.
• W2946811215 cites W2518653162 @default.
• W2946811215 cites W2528651262 @default.
• W2946811215 cites W2597159973 @default.
• W2946811215 cites W2883703281 @default.
• W2946811215 doi "https://doi.org/10.1002/1878-0261.12504" @default.
• W2946811215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6670013" @default.
• W2946811215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31094056" @default.
• W2946811215 hasPublicationYear "2019" @default.
• W2946811215 type Work @default.
• W2946811215 sameAs 2946811215 @default.
• W2946811215 citedByCount "36" @default.
• W2946811215 countsByYear W29468112152019 @default.
• W2946811215 countsByYear W29468112152020 @default.
• W2946811215 countsByYear W29468112152021 @default.
• W2946811215 countsByYear W29468112152022 @default.
• W2946811215 countsByYear W29468112152023 @default.
• W2946811215 crossrefType "journal-article" @default.
• W2946811215 hasAuthorship W2946811215A5015825703 @default.
• W2946811215 hasAuthorship W2946811215A5027873799 @default.
• W2946811215 hasAuthorship W2946811215A5039550839 @default.
• W2946811215 hasAuthorship W2946811215A5046087332 @default.
• W2946811215 hasAuthorship W2946811215A5048426787 @default.
• W2946811215 hasAuthorship W2946811215A5050984306 @default.
• W2946811215 hasAuthorship W2946811215A5051009186 @default.
• W2946811215 hasAuthorship W2946811215A5052170454 @default.
• W2946811215 hasAuthorship W2946811215A5064568192 @default.
• W2946811215 hasAuthorship W2946811215A5067509135 @default.
• W2946811215 hasAuthorship W2946811215A5077293541 @default.
• W2946811215 hasAuthorship W2946811215A5082105510 @default.
• W2946811215 hasBestOaLocation W29468112151 @default.
• W2946811215 hasConcept C104317684 @default.
• W2946811215 hasConcept C118131993 @default.
• W2946811215 hasConcept C142724271 @default.

• next