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- W2946824772 abstract "The relationship between platelet function and bleeding tendency was studied in 42 patients undergoing open heart surgery. Template bleeding time (TBT) and hourly chest tube outflow were measured as indices of bleeding tendency. Platelet function tests included platelet count (PC), aggregation with epinephrine, ADP, and collagen, and a modified platelet slide adhesion test (PSAT) which allowed us to quantitate in vivo the relative amount of more adhesive platelets, i. e., the “spread” forms, as compared to the number of smaller non-adhesive platelets. Post operatively the PC decreased 36% (from 214.1 ± 11.4 K to 136.3 ± 6.8 K, p<0.001) in all patients irrespective of the amount of blood loss. Using the PSAT, the product of the % “spread” forms and the PC showed a significant 57% decrease (from 110.5 ± 7.4 K to 47.4 ± 4.6 K, p<0.001) which was 19% more than the PC decrease implying that the more adhesive platelets had been expended. TBT increased significantly (7.7 ± 0.5 min. to 17.7 ± 1.3 min., p<0.001) and aggregation to epinephrine decreased significantly (60.9 ± 4.8% to 36.0 ± 3.4%, p<0.001), but no significant change was noted with ADP or collagen. There was no significant difference in the above parameters between patients bleeding more than 113 cc/hr. from 1 to 5 hrs. post op (N=14) and those bleeding less (N=28). A second study of 16 patients with bleeders having >1000 cc output in the first 4 hrs. post op showed results similar to the first group comparing pre vs. post and bleeders (N=8) vs. non-bleeders. This study indicates that after cardiopulmonary bypass surgery platelet function is frequently compromised and this dysfunction though probably contributing to a bleeding tendency did not correlate well with the magnitude of blood loss." @default.
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- W2946824772 date "1977-01-01" @default.
- W2946824772 modified "2023-09-28" @default.
- W2946824772 title "Platelet Function and Blood Loss after Cardiopulmonary Bypass" @default.
- W2946824772 doi "https://doi.org/10.1055/s-0039-1680412" @default.
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