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- W2946829710 abstract "Background & Aim Cell therapy for patients with acute-on-chronic liver failure (ACLF), which is associated with high short-term mortality, is a promising strategy. We reasoned that administering stromal vascular cell (SVF) therapy to achieve cell-mediated microenvironment modulation for liver regeneration and hepatocyte replenishment in ACLF is an attractive alternative strategy to liver transplantation. We evaluated the perturbation of microenvironment by CD34+/CD34− SVF cells in hepatocyte cotransplantation in a rat model of ACLF regarding selected gene expression. Methods, Results & Conclusion Donor hepatocytes (1 × 107/1mL) and SVF cells (1 × 106/0.5mL) were isolated from Tg(UBC–emGFP) rats and human adipose tissues, respectively, and were intraportally transplanted into ACLF rats. SVF cells were divided into CD34+ and CD34− groups. The surviving animals were sacrificed at 1 and 2 weeks after the transplantation. Gene expression levels, measured by quantitative real-time RT-PCR, were normalized against endogenous glyceraldehyde-3-phosphatedehydrogenase control. Histologically, prominent biliary ductular proliferation and significantly progression of fibrosis (P = 0.005) were observed in the CD34− group than in the CD34+ group. Genes directly related to the end result of fibrosis (collagen type I, MMP9, and TIMP1) showed significantly higher expression in the CD34− group than in the CD34+ group at 1 week after cell transplantation (P In conclusion, hepatic gene expression in the rat model of ACLF after cytotherapy of SVF cells and hepatocytes were differed with CD34 positivity. CD34+ SVF was instrumental in mediating hepatic repair." @default.
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- W2946829710 date "2019-05-01" @default.
- W2946829710 modified "2023-09-27" @default.
- W2946829710 title "CD34+ stromal vascular fraction was instrumental in mediating hepatic repair regarding gene expression profiles" @default.
- W2946829710 doi "https://doi.org/10.1016/j.jcyt.2019.04.030" @default.
- W2946829710 hasPublicationYear "2019" @default.
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