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• W2946854441 startingPage "112556" @default.
• W2946854441 abstract "For this series of experiments, we wanted to investigate issues related to stress and learning. First, we wanted to determine if unpredictable stress might foster generalized fear responses more than predictable stress. Second, we wanted to evaluate how repeated stress might influence a rat's ability to learn what context predicts and an aversive event. Our first hypothesis was that unpredictable stress would result in generalized fear responses compared to predictable stress and these effects would worsen over repeated stress cycles. Our second hypothesis was that stress, regardless of type, would result in enhanced discriminative fear conditioning to context, a measure of fear learning. Accordingly, two groups of rats received 14-day restraint stress with one group receiving predictable while the other group received unpredictable stress. Following these experimental manipulations, both groups were given a recovery period and then an assessment of fear-based context discriminative behaviour was performed. This stress-recovery cycle was repeated, and fear conditioning was again assessed. After a single stress-recovery cycle discriminative fear conditioning to context was not impaired for either group. However, we did find that unpredictable stress facilitated behavioural expression of fear in a fearful context. Following two stress-recovery cycles the unpredictable group exhibited discriminative freezing that was elevated within the paired context, whereas, surprisingly, the predictable group did not exhibit differentiated freezing and instead spent similar amounts of time freezing in both contexts. This pattern of effects suggests that unpredictable chronic stress fostered fearful behaviour in the presence of a threatening context, whereas generalized fear is brought about by repeated predictable stress. This result is the opposite of our hypothesis that unpredictable stress would result in generalized fear. Taken together these results show that certain types of stressful experiences (unpredictable) enhance discriminative fear conditioning to context and stress over a longer period can produce generalized fear, but surprisingly in the predictable and not unpredictable condition." @default.
• W2946854441 created "2019-06-07" @default.
• W2946854441 creator A5029423551 @default.
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• W2946854441 date "2019-09-01" @default.
• W2946854441 modified "2023-09-27" @default.
• W2946854441 title "Comparison of the effects of repeated exposures to predictable or unpredictable stress on the behavioural expression of fear in a discriminative fear conditioning to context task" @default.
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• W2946854441 doi "https://doi.org/10.1016/j.physbeh.2019.05.017" @default.
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