Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946909110> ?p ?o ?g. }
- W2946909110 abstract "Abstract In prostate carcinogenesis, expression and/or activation of the Transient Receptor Potential Melastatin 8 channel (TRPM8) was shown to block in vitro Prostate Cancer (PCa) cell migration. Because of their localization at the plasma membrane, ion channels, such as TRPM8 and other membrane receptors, are promising pharmacological targets. The aim of this study was thus to use nanocarriers encapsulating a TRPM8 agonist to efficiently activate the channel and therefore arrest PCa cell migration. To achieve this goal, the most efficient TRPM8 agonist, WS12, was encapsulated into Lipid NanoCapsules (LNC). The effect of the nanocarriers on channel activity and cellular physiological processes, such as cell viability and migration, were evaluated in vitro and in vivo . These results provide a proof-of-concept support for using TRPM8 channel-targeting nanotechnologies based on LNC to develop more effective methods inhibiting PCa cell migration in zebrafish xenograft." @default.
- W2946909110 created "2019-06-07" @default.
- W2946909110 creator A5007220163 @default.
- W2946909110 creator A5012666659 @default.
- W2946909110 creator A5013979737 @default.
- W2946909110 creator A5019019615 @default.
- W2946909110 creator A5022542699 @default.
- W2946909110 creator A5034146768 @default.
- W2946909110 creator A5038232051 @default.
- W2946909110 creator A5041883914 @default.
- W2946909110 creator A5049299453 @default.
- W2946909110 creator A5056234955 @default.
- W2946909110 creator A5076667801 @default.
- W2946909110 creator A5082961482 @default.
- W2946909110 creator A5088026147 @default.
- W2946909110 date "2019-05-28" @default.
- W2946909110 modified "2023-10-11" @default.
- W2946909110 title "Encapsulation of a TRPM8 Agonist, WS12, in Lipid Nanocapsules Potentiates PC3 Prostate Cancer Cell Migration Inhibition through Channel Activation" @default.
- W2946909110 cites W1205374584 @default.
- W2946909110 cites W1757407923 @default.
- W2946909110 cites W1968418753 @default.
- W2946909110 cites W1973162731 @default.
- W2946909110 cites W1975076384 @default.
- W2946909110 cites W1978128137 @default.
- W2946909110 cites W1979110270 @default.
- W2946909110 cites W1988943017 @default.
- W2946909110 cites W1995330222 @default.
- W2946909110 cites W1999396198 @default.
- W2946909110 cites W2003906765 @default.
- W2946909110 cites W2010928352 @default.
- W2946909110 cites W2022293360 @default.
- W2946909110 cites W2023966260 @default.
- W2946909110 cites W2027491627 @default.
- W2946909110 cites W2041322673 @default.
- W2946909110 cites W2045657423 @default.
- W2946909110 cites W2051516831 @default.
- W2946909110 cites W2051697361 @default.
- W2946909110 cites W2052768789 @default.
- W2946909110 cites W2058808922 @default.
- W2946909110 cites W2070559228 @default.
- W2946909110 cites W2071947898 @default.
- W2946909110 cites W2082975959 @default.
- W2946909110 cites W2089531185 @default.
- W2946909110 cites W2090617423 @default.
- W2946909110 cites W2091760375 @default.
- W2946909110 cites W2092893542 @default.
- W2946909110 cites W2107057154 @default.
- W2946909110 cites W2113506065 @default.
- W2946909110 cites W2120229762 @default.
- W2946909110 cites W2129801876 @default.
- W2946909110 cites W2132813105 @default.
- W2946909110 cites W2137025890 @default.
- W2946909110 cites W2145311545 @default.
- W2946909110 cites W2147451806 @default.
- W2946909110 cites W2153601543 @default.
- W2946909110 cites W2161845665 @default.
- W2946909110 cites W2165732324 @default.
- W2946909110 cites W2166797811 @default.
- W2946909110 cites W2167279371 @default.
- W2946909110 cites W2169515226 @default.
- W2946909110 cites W2300552860 @default.
- W2946909110 cites W2520554641 @default.
- W2946909110 cites W2598062636 @default.
- W2946909110 cites W2736590682 @default.
- W2946909110 cites W2775387645 @default.
- W2946909110 cites W2994234715 @default.
- W2946909110 doi "https://doi.org/10.1038/s41598-019-44452-4" @default.
- W2946909110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6538610" @default.
- W2946909110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31138874" @default.
- W2946909110 hasPublicationYear "2019" @default.
- W2946909110 type Work @default.
- W2946909110 sameAs 2946909110 @default.
- W2946909110 citedByCount "22" @default.
- W2946909110 countsByYear W29469091102019 @default.
- W2946909110 countsByYear W29469091102020 @default.
- W2946909110 countsByYear W29469091102021 @default.
- W2946909110 countsByYear W29469091102022 @default.
- W2946909110 countsByYear W29469091102023 @default.
- W2946909110 crossrefType "journal-article" @default.
- W2946909110 hasAuthorship W2946909110A5007220163 @default.
- W2946909110 hasAuthorship W2946909110A5012666659 @default.
- W2946909110 hasAuthorship W2946909110A5013979737 @default.
- W2946909110 hasAuthorship W2946909110A5019019615 @default.
- W2946909110 hasAuthorship W2946909110A5022542699 @default.
- W2946909110 hasAuthorship W2946909110A5034146768 @default.
- W2946909110 hasAuthorship W2946909110A5038232051 @default.
- W2946909110 hasAuthorship W2946909110A5041883914 @default.
- W2946909110 hasAuthorship W2946909110A5049299453 @default.
- W2946909110 hasAuthorship W2946909110A5056234955 @default.
- W2946909110 hasAuthorship W2946909110A5076667801 @default.
- W2946909110 hasAuthorship W2946909110A5082961482 @default.
- W2946909110 hasAuthorship W2946909110A5088026147 @default.
- W2946909110 hasBestOaLocation W29469091101 @default.
- W2946909110 hasConcept C121608353 @default.
- W2946909110 hasConcept C126322002 @default.
- W2946909110 hasConcept C137738243 @default.
- W2946909110 hasConcept C1491633281 @default.
- W2946909110 hasConcept C150903083 @default.
- W2946909110 hasConcept C155164980 @default.
- W2946909110 hasConcept C155672457 @default.