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- W2946918058 endingPage "255" @default.
- W2946918058 startingPage "255" @default.
- W2946918058 abstract "Predictions made soon after the introduction of human immunodeficiency virus type-1 (HIV-1) protease inhibitors about potentially eradicating the cellular reservoirs of HIV-1 in infected individuals were too optimistic. The ability of the HIV-1 genome to remain in the chromosomes of resting CD4+ T cells and macrophages without being expressed (HIV-1 latency) has prompted studies to activate the cells in the hopes that the immune system can recognize and clear these cells. The absence of natural clearance of latently infected cells has led to the recognition that additional interventions are necessary. Here, we review the potential of utilizing suicide gene therapy to kill infected cells, excising the chromosome-integrated HIV-1 DNA, and targeting cytotoxic liposomes to latency-reversed HIV-1-infected cells." @default.
- W2946918058 created "2019-06-07" @default.
- W2946918058 creator A5053036185 @default.
- W2946918058 creator A5073423746 @default.
- W2946918058 date "2019-06-01" @default.
- W2946918058 modified "2023-09-25" @default.
- W2946918058 title "Eradication of Human Immunodeficiency Virus Type-1 (HIV-1)-Infected Cells" @default.
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- W2946918058 doi "https://doi.org/10.3390/pharmaceutics11060255" @default.
- W2946918058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6631149" @default.
- W2946918058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31159417" @default.
- W2946918058 hasPublicationYear "2019" @default.