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• W2946935162 abstract "ABSTRACT Objectives: We aimed to explore the ability of magnetic resonance enterography (MRE) to impute the simple endoscopic score of Crohn disease (SES-CD) in children with CD, in whom failure of ileal intubation is common and may impair SES-CD calculation in clinical studies. Methods: This is a substudy of the prospective ImageKids study in which children with CD underwent ileocolonoscopy (scored by SES-CD) and MRE (scored on a 100 mm visual analogue scale [VAS] and by MaRIA). Mucosal healing (MH) was defined as SES-CD <3, MRE-VAS <20 mm, and/or MaRIA <7. Results: A total of 237 children (22 centers, age 11.5 ± 3.3 years), were enrolled. Ileal intubation has failed in 40 of 237 (17%). The agreement between SES-CD and MRE was 75% ( k = 0.508, P < 0.001) in the ileum, and 68% to 85% in the colonic segments ( k = 0.21–0.50, P < 0.001). The sensitivity and specificity of ileal MRE-VAS for MH were 91.7% (95% confidence interval 0.84–0.96) and 53.1% (95% confidence interval 0.43–0.63), respectively. The ileal MaRIA score (calculated in 33/40) was higher in the children without ileal intubation than in the others (20.5 ± 7.1 vs 15.1 ± 10.8, respectively, P = 0.0018). In 7% (16/237) of children, isolated active ileal disease would have been missed when considering SES-CD only. A multivariable model predicted the ileal SES-CD subscore from the MaRIA: SES-CD ileum = 1.145 + 0.169 × MaRIA ileum rounded to the nearest whole number ( R 2 = 0.17). Applying this model to the children without ileal intubation revealed that 29 of 33 (88%) had ileal disease; 8 of 29 patients (28%) with normal colonic SES-CD had imputed ileal SES-CD ≥3. Conclusions: MRE is useful for imputing the ileal disease in pediatric clinical studies, overcoming the problem of ileal nonintubation." @default.
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• W2946935162 date "2019-10-01" @default.
• W2946935162 modified "2023-10-18" @default.
• W2946935162 title "Simple Endoscopic Score of Crohn Disease and Magnetic Resonance Enterography in Children: Report From ImageKids Study" @default.
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• W2946935162 doi "https://doi.org/10.1097/mpg.0000000000002404" @default.
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