FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946960982> ?p ?o ?g. }

• W2946960982 endingPage "798" @default.
• W2946960982 startingPage "786" @default.
• W2946960982 abstract "Abstract Ctenophores, also known as comb jellies, live across extremely broad ranges of temperature and hydrostatic pressure in the ocean. Because various ctenophore lineages adapted independently to similar environmental conditions, Phylum Ctenophora is an ideal system for the study of protein adaptation to extreme environments in a comparative framework. We present such a study here, using a phylogenetically-informed method to compare sequences of four essential metabolic enzymes across gradients of habitat depth and temperature. This method predicts convergent adaptation to these environmental parameters at the amino acid level, providing a novel view of protein adaptation to extreme environments and demonstrating the power and relevance of phylogenetic comparison applied to multi-species transcriptomic datasets from early-diverging metazoa. Across all four enzymes analyzed, 46 amino acid sites were associated with depth-adaptation, 59 with temperature-adaptation, and 56 with both. Sites predicted to be depth- and temperature-adaptive occurred consistently near Rossmann fold cofactor binding motifs and disproportionately in solvent-exposed regions of the protein. These results suggest that the hydrophobic effect and ligand binding may mediate efficient enzyme function at different hydrostatic pressures and temperatures. Using predicted adaptive site maps, such mechanistic hypotheses can now be tested via mutagenesis." @default.
• W2946960982 created "2019-06-07" @default.
• W2946960982 creator A5016576758 @default.
• W2946960982 creator A5060375473 @default.
• W2946960982 creator A5077757561 @default.
• W2946960982 creator A5079976782 @default.
• W2946960982 date "2019-05-29" @default.
• W2946960982 modified "2023-10-15" @default.
• W2946960982 title "Combing Transcriptomes for Secrets of Deep-Sea Survival: Environmental Diversity Drives Patterns of Protein Evolution" @default.
• W2946960982 cites W13084258 @default.
• W2946960982 cites W1511980712 @default.
• W2946960982 cites W1513720422 @default.
• W2946960982 cites W1592418946 @default.
• W2946960982 cites W1900937478 @default.
• W2946960982 cites W1937124658 @default.
• W2946960982 cites W1967814055 @default.
• W2946960982 cites W1987388013 @default.
• W2946960982 cites W1996910717 @default.
• W2946960982 cites W2008438855 @default.
• W2946960982 cites W2011657487 @default.
• W2946960982 cites W2013392714 @default.
• W2946960982 cites W2028410507 @default.
• W2946960982 cites W2031778321 @default.
• W2946960982 cites W2037312364 @default.
• W2946960982 cites W2039462617 @default.
• W2946960982 cites W2046569329 @default.
• W2946960982 cites W2046793790 @default.
• W2946960982 cites W2057064815 @default.
• W2946960982 cites W2059143808 @default.
• W2946960982 cites W2074670905 @default.
• W2946960982 cites W2076469180 @default.
• W2946960982 cites W2078458005 @default.
• W2946960982 cites W2078913419 @default.
• W2946960982 cites W2080280611 @default.
• W2946960982 cites W2089502464 @default.
• W2946960982 cites W2090336686 @default.
• W2946960982 cites W2097340329 @default.
• W2946960982 cites W2106269045 @default.
• W2946960982 cites W2110428327 @default.
• W2946960982 cites W2111485477 @default.
• W2946960982 cites W2113991587 @default.
• W2946960982 cites W2122700446 @default.
• W2946960982 cites W2127703820 @default.
• W2946960982 cites W2131641638 @default.
• W2946960982 cites W2141052558 @default.
• W2946960982 cites W2160260756 @default.
• W2946960982 cites W2163508057 @default.
• W2946960982 cites W2166539760 @default.
• W2946960982 cites W2289077802 @default.
• W2946960982 cites W2510009051 @default.
• W2946960982 cites W2548643850 @default.
• W2946960982 cites W2600816737 @default.
• W2946960982 cites W2619822633 @default.
• W2946960982 cites W2767035168 @default.
• W2946960982 cites W2782262419 @default.
• W2946960982 cites W2785092601 @default.
• W2946960982 cites W2949126322 @default.
• W2946960982 cites W2950950814 @default.
• W2946960982 cites W2952286239 @default.
• W2946960982 cites W4233975312 @default.
• W2946960982 cites W64558573 @default.
• W2946960982 doi "https://doi.org/10.1093/icb/icz063" @default.
• W2946960982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6797910" @default.
• W2946960982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31141128" @default.
• W2946960982 hasPublicationYear "2019" @default.
• W2946960982 type Work @default.
• W2946960982 sameAs 2946960982 @default.
• W2946960982 citedByCount "4" @default.
• W2946960982 countsByYear W29469609822019 @default.
• W2946960982 countsByYear W29469609822020 @default.
• W2946960982 countsByYear W29469609822021 @default.
• W2946960982 crossrefType "journal-article" @default.
• W2946960982 hasAuthorship W2946960982A5016576758 @default.
• W2946960982 hasAuthorship W2946960982A5060375473 @default.
• W2946960982 hasAuthorship W2946960982A5077757561 @default.
• W2946960982 hasAuthorship W2946960982A5079976782 @default.
• W2946960982 hasBestOaLocation W29469609821 @default.
• W2946960982 hasConcept C104317684 @default.
• W2946960982 hasConcept C104397665 @default.
• W2946960982 hasConcept C121332964 @default.
• W2946960982 hasConcept C139807058 @default.
• W2946960982 hasConcept C150194340 @default.
• W2946960982 hasConcept C162317418 @default.
• W2946960982 hasConcept C169760540 @default.
• W2946960982 hasConcept C177606310 @default.
• W2946960982 hasConcept C18903297 @default.
• W2946960982 hasConcept C193252679 @default.
• W2946960982 hasConcept C2910081258 @default.
• W2946960982 hasConcept C515207424 @default.
• W2946960982 hasConcept C54355233 @default.
• W2946960982 hasConcept C70721500 @default.
• W2946960982 hasConcept C78458016 @default.
• W2946960982 hasConcept C86803240 @default.
• W2946960982 hasConcept C88654294 @default.
• W2946960982 hasConcept C97355855 @default.
• W2946960982 hasConceptScore W2946960982C104317684 @default.
• W2946960982 hasConceptScore W2946960982C104397665 @default.
• W2946960982 hasConceptScore W2946960982C121332964 @default.

• next