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• W2946968484 abstract "A new approach is presented for the study of (H_infty ) optimal control of biochemical pathways. Starting with various linear models of single enzymatic reaction systems, a simple unbranched four-block enzyme system that contains a negative feedback loop is analyzed in the open- and the closed-loop configurations, where it is shown that the closed-loop configuration is one of the static output-feedback control systems. The original nonlinear four-block system is modeled as a polytopic-type uncertain linear system, where the extent of the nonlinearity can be “tuned” by a fictitious uncertainty interval, thus better capturing the nonlinear nature of the systems under study. The sensitivity of the latter enzymatic system to variations in certain variables is explored via the optimal (H_infty ) control approach. Based on this approach, the threonine synthesis pathway that contains three negative feedback loops is analyzed and is shown to be optimal in the (H_infty ) sense." @default.
• W2946968484 created "2019-06-07" @default.
• W2946968484 creator A5029020038 @default.
• W2946968484 creator A5031334842 @default.
• W2946968484 date "2019-01-01" @default.
• W2946968484 modified "2023-09-27" @default.
• W2946968484 title "$$H_infty $$ Feedback Control Theory in Biochemical Systems" @default.
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• W2946968484 doi "https://doi.org/10.1007/978-3-030-16008-1_16" @default.
• W2946968484 hasPublicationYear "2019" @default.
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