Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946971610> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2946971610 abstract "e20066 Background: Malignant pleural mesothelioma is a rare malignancy with an annual incidence of 3,000 cases in the US and is still considered incurable. The standard of care for this cancer, a combination of pemetrexed and a platinum drug, was established in 2003 as the result of a landmark study that reported a median overall survival of 12.1 months for this combination in patients not eligible for surgery. The aim of the current analysis was to determine if there has been a change in the outcome for this population in the past 15 years. Methods: A PubMed search was performed and 9 prospective, randomized or single arm (minimum n = 50), trials were selected. All studies included patients treated using pemetrexed in combination with platimun as front line therapy in unresectable mesothelioma patients. Average and weighted average OS were calculated and also corrected per the reported odds ratio for survival between the epithelioid and non-epithelioid histologies. Results: The average OS was 12.9 months and the weighted average OS was 13.3 months (range: 8.5 – 16.1 months). The two studies showing the highest median OS (MAPS and LUME-meso) had a higher percentage of tumors with epithelioid histology, which could explain their favorable outcome. Adjusting the average OS using the reported odds ratios for survival between epithelioid and non-epithelioid histologies eliminated the superior outcome in these studies. Furthermore, correcting average survival per the original ratio between tumor histologies for all studies included in the meta-analysis showed an average and weighted average OS lower than 13 months. Conclusions: This analysis strongly supports the contention that survival results for nonoperative patients with mesothelioma should be stratified by histology, epithelioid versus nonepithelioid, similar to the trend in the surgical mesothelioma literature. When factoring in histology, it appears that overall advances in patient care and additional treatments have not significantly changed the overall survival for nonoperative mesothelioma patients in the last 15 years. This meta-analysis underscores the desperate need for new and innovative treatments for this cancer." @default.
- W2946971610 created "2019-06-07" @default.
- W2946971610 creator A5028293121 @default.
- W2946971610 creator A5089296744 @default.
- W2946971610 date "2019-05-20" @default.
- W2946971610 modified "2023-09-24" @default.
- W2946971610 title "Survival meta-analysis from fifteen years of a standard systemic therapy in malignant pleural mesothelioma." @default.
- W2946971610 doi "https://doi.org/10.1200/jco.2019.37.15_suppl.e20066" @default.
- W2946971610 hasPublicationYear "2019" @default.
- W2946971610 type Work @default.
- W2946971610 sameAs 2946971610 @default.
- W2946971610 citedByCount "0" @default.
- W2946971610 crossrefType "journal-article" @default.
- W2946971610 hasAuthorship W2946971610A5028293121 @default.
- W2946971610 hasAuthorship W2946971610A5089296744 @default.
- W2946971610 hasConcept C120665830 @default.
- W2946971610 hasConcept C121332964 @default.
- W2946971610 hasConcept C121608353 @default.
- W2946971610 hasConcept C126322002 @default.
- W2946971610 hasConcept C142724271 @default.
- W2946971610 hasConcept C143998085 @default.
- W2946971610 hasConcept C185926286 @default.
- W2946971610 hasConcept C191897082 @default.
- W2946971610 hasConcept C192562407 @default.
- W2946971610 hasConcept C2776178081 @default.
- W2946971610 hasConcept C2776256026 @default.
- W2946971610 hasConcept C2776517811 @default.
- W2946971610 hasConcept C2777407522 @default.
- W2946971610 hasConcept C2777714996 @default.
- W2946971610 hasConcept C2779399171 @default.
- W2946971610 hasConcept C2993769353 @default.
- W2946971610 hasConcept C510490043 @default.
- W2946971610 hasConcept C530470458 @default.
- W2946971610 hasConcept C61511704 @default.
- W2946971610 hasConcept C71924100 @default.
- W2946971610 hasConceptScore W2946971610C120665830 @default.
- W2946971610 hasConceptScore W2946971610C121332964 @default.
- W2946971610 hasConceptScore W2946971610C121608353 @default.
- W2946971610 hasConceptScore W2946971610C126322002 @default.
- W2946971610 hasConceptScore W2946971610C142724271 @default.
- W2946971610 hasConceptScore W2946971610C143998085 @default.
- W2946971610 hasConceptScore W2946971610C185926286 @default.
- W2946971610 hasConceptScore W2946971610C191897082 @default.
- W2946971610 hasConceptScore W2946971610C192562407 @default.
- W2946971610 hasConceptScore W2946971610C2776178081 @default.
- W2946971610 hasConceptScore W2946971610C2776256026 @default.
- W2946971610 hasConceptScore W2946971610C2776517811 @default.
- W2946971610 hasConceptScore W2946971610C2777407522 @default.
- W2946971610 hasConceptScore W2946971610C2777714996 @default.
- W2946971610 hasConceptScore W2946971610C2779399171 @default.
- W2946971610 hasConceptScore W2946971610C2993769353 @default.
- W2946971610 hasConceptScore W2946971610C510490043 @default.
- W2946971610 hasConceptScore W2946971610C530470458 @default.
- W2946971610 hasConceptScore W2946971610C61511704 @default.
- W2946971610 hasConceptScore W2946971610C71924100 @default.
- W2946971610 hasLocation W29469716101 @default.
- W2946971610 hasOpenAccess W2946971610 @default.
- W2946971610 hasPrimaryLocation W29469716101 @default.
- W2946971610 hasRelatedWork W1984248279 @default.
- W2946971610 hasRelatedWork W2010761400 @default.
- W2946971610 hasRelatedWork W2021397854 @default.
- W2946971610 hasRelatedWork W2032987333 @default.
- W2946971610 hasRelatedWork W2182565509 @default.
- W2946971610 hasRelatedWork W2195573446 @default.
- W2946971610 hasRelatedWork W2334816928 @default.
- W2946971610 hasRelatedWork W2416103825 @default.
- W2946971610 hasRelatedWork W2416446770 @default.
- W2946971610 hasRelatedWork W2460285199 @default.
- W2946971610 hasRelatedWork W2566982091 @default.
- W2946971610 hasRelatedWork W2591029035 @default.
- W2946971610 hasRelatedWork W2598985572 @default.
- W2946971610 hasRelatedWork W2603130183 @default.
- W2946971610 hasRelatedWork W275460098 @default.
- W2946971610 hasRelatedWork W2946966177 @default.
- W2946971610 hasRelatedWork W2972888625 @default.
- W2946971610 hasRelatedWork W2981612503 @default.
- W2946971610 hasRelatedWork W2989185162 @default.
- W2946971610 hasRelatedWork W3170692956 @default.
- W2946971610 isParatext "false" @default.
- W2946971610 isRetracted "false" @default.
- W2946971610 magId "2946971610" @default.
- W2946971610 workType "article" @default.