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- W2946972585 abstract "Research on lipid/drug interactions at the nanoscale underpins the emergence of synergistic mechanisms for topical drug administration. The structural understanding of bio-mimetic systems employing 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) as a lung surfactant model mixed with antibiotics, as well as their biophysical properties, is of critical importance to modulate the effectiveness of therapeutic agents released directly to the airways. In this paper, we investigate the structural details of the interaction between Levofloxacin, 'a respiratory quinolone', and the macrolide Clarithromycin, with DPPC monolayers at the air-water interface, using a combination of Brewster angle microscopy, polarization modulation-infrared reflection-adsorption spectroscopy (PM-IRRAS), surface pressure isotherms and neutron reflectometry (NR) to describe the structural details of this interaction. The results allowed association of changes in the π-A isotherm profile with changes in the molecular organization and the co-localization of the antibiotics within the lipid monolayer by NR measurements. Overall, both antibiotics are able to increase the thickness of the acyl tails in DPPC monolayers with a corresponding reduction in tail tilt as well as to interact with the phospholipid headgroups as shown by PM-IRRAS experiments. The effects on the DPPC monolayers are correlated with the physical-chemical properties of each antibiotic and dependent on its concentration." @default.
- W2946972585 created "2019-06-07" @default.
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- W2946972585 date "2019-10-01" @default.
- W2946972585 modified "2023-09-29" @default.
- W2946972585 title "Influence of levofloxacin and clarithromycin on the structure of DPPC monolayers" @default.
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- W2946972585 cites W1976663468 @default.
- W2946972585 cites W1977156325 @default.
- W2946972585 cites W1981984118 @default.
- W2946972585 cites W1982041242 @default.
- W2946972585 cites W1982988725 @default.
- W2946972585 cites W1983393027 @default.
- W2946972585 cites W1995616290 @default.
- W2946972585 cites W2002372426 @default.
- W2946972585 cites W2007559168 @default.
- W2946972585 cites W2008336038 @default.
- W2946972585 cites W2013571033 @default.
- W2946972585 cites W2014311917 @default.
- W2946972585 cites W2016989826 @default.
- W2946972585 cites W2021269540 @default.
- W2946972585 cites W2022670913 @default.
- W2946972585 cites W2026504001 @default.
- W2946972585 cites W2027214692 @default.
- W2946972585 cites W2030266401 @default.
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- W2946972585 cites W2050636961 @default.
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- W2946972585 doi "https://doi.org/10.1016/j.bbamem.2019.05.016" @default.
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- W2946972585 hasPublicationYear "2019" @default.
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