Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946973845> ?p ?o ?g. }
- W2946973845 abstract "In mammals, the hibernating state is characterized by biochemical adjustments, which include metabolic rate depression and a shift in the primary fuel oxidized from carbohydrates to lipids. A number of studies of hibernating species report an upregulation of the levels and/or activity of lipid oxidizing enzymes in muscles during torpor, with a concomitant downregulation for glycolytic enzymes. However, other studies provide contrasting data about the regulation of fuel utilization in skeletal muscles during hibernation. Bears hibernate with only moderate hypothermia but with a drop in metabolic rate down to ~ 25% of basal metabolism. To gain insights into how fuel metabolism is regulated in hibernating bear skeletal muscles, we examined the vastus lateralis proteome and other changes elicited in brown bears during hibernation. We show that bear muscle metabolic reorganization is in line with a suppression of ATP turnover. Regulation of muscle enzyme expression and activity, as well as of circulating metabolite profiles, highlighted a preference for lipid substrates during hibernation, although the data suggested that muscular lipid oxidation levels decreased due to metabolic rate depression. Our data also supported maintenance of muscle glycolysis that could be fuelled from liver gluconeogenesis and mobilization of muscle glycogen stores. During hibernation, our data also suggest that carbohydrate metabolism in bear muscle, as well as protein sparing, could be controlled, in part, by actions of n-3 polyunsaturated fatty acids like docosahexaenoic acid. Our work shows that molecular mechanisms in hibernating bear skeletal muscle, which appear consistent with a hypometabolic state, likely contribute to energy and protein savings. Maintenance of glycolysis could help to sustain muscle functionality for situations such as an unexpected exit from hibernation that would require a rapid increase in ATP production for muscle contraction. The molecular data we report here for skeletal muscles of bears hibernating at near normal body temperature represent a signature of muscle preservation despite atrophying conditions." @default.
- W2946973845 created "2019-06-07" @default.
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- W2946973845 date "2019-05-06" @default.
- W2946973845 modified "2023-09-30" @default.
- W2946973845 title "Metabolic reprogramming involving glycolysis in the hibernating brown bear skeletal muscle" @default.
- W2946973845 cites W1489679817 @default.
- W2946973845 cites W1498743513 @default.
- W2946973845 cites W1857956436 @default.
- W2946973845 cites W1956327946 @default.
- W2946973845 cites W1966670480 @default.
- W2946973845 cites W1972614642 @default.
- W2946973845 cites W1973175580 @default.
- W2946973845 cites W1991042480 @default.
- W2946973845 cites W1991916877 @default.
- W2946973845 cites W1995565902 @default.
- W2946973845 cites W1997110756 @default.
- W2946973845 cites W2000067605 @default.
- W2946973845 cites W2003162584 @default.
- W2946973845 cites W2011024719 @default.
- W2946973845 cites W2013607204 @default.
- W2946973845 cites W2014374621 @default.
- W2946973845 cites W2015454275 @default.
- W2946973845 cites W2027440191 @default.
- W2946973845 cites W2029304541 @default.
- W2946973845 cites W2038380180 @default.
- W2946973845 cites W2041637137 @default.
- W2946973845 cites W2043079296 @default.
- W2946973845 cites W2050563847 @default.
- W2946973845 cites W2051323621 @default.
- W2946973845 cites W2058151416 @default.
- W2946973845 cites W2060335757 @default.
- W2946973845 cites W2061729937 @default.
- W2946973845 cites W2063028213 @default.
- W2946973845 cites W2064676676 @default.
- W2946973845 cites W2065222703 @default.
- W2946973845 cites W2071313868 @default.
- W2946973845 cites W2079758456 @default.
- W2946973845 cites W2081546582 @default.
- W2946973845 cites W2085467491 @default.
- W2946973845 cites W2095246084 @default.
- W2946973845 cites W2107520997 @default.
- W2946973845 cites W2108456034 @default.
- W2946973845 cites W2113212587 @default.
- W2946973845 cites W2121168414 @default.
- W2946973845 cites W2122481289 @default.
- W2946973845 cites W2127485481 @default.
- W2946973845 cites W2134017403 @default.
- W2946973845 cites W2135581618 @default.
- W2946973845 cites W2140609274 @default.
- W2946973845 cites W2141683865 @default.
- W2946973845 cites W2149655675 @default.
- W2946973845 cites W2150123796 @default.
- W2946973845 cites W2150297520 @default.
- W2946973845 cites W2150318663 @default.
- W2946973845 cites W2150382441 @default.
- W2946973845 cites W2153562609 @default.
- W2946973845 cites W2153938802 @default.
- W2946973845 cites W2155538197 @default.
- W2946973845 cites W2159693138 @default.
- W2946973845 cites W2162234541 @default.
- W2946973845 cites W2164209362 @default.
- W2946973845 cites W2167763573 @default.
- W2946973845 cites W2170776626 @default.
- W2946973845 cites W2173857530 @default.
- W2946973845 cites W2194948685 @default.
- W2946973845 cites W2261811224 @default.
- W2946973845 cites W2266325089 @default.
- W2946973845 cites W2290339933 @default.
- W2946973845 cites W2345268861 @default.
- W2946973845 cites W2406154391 @default.
- W2946973845 cites W2413246767 @default.
- W2946973845 cites W2460273480 @default.
- W2946973845 cites W2475561847 @default.
- W2946973845 cites W2512425402 @default.
- W2946973845 cites W2739281286 @default.
- W2946973845 cites W2742198484 @default.
- W2946973845 cites W2755771303 @default.
- W2946973845 cites W2773645177 @default.
- W2946973845 cites W2796671431 @default.
- W2946973845 cites W2889732858 @default.
- W2946973845 cites W3161309375 @default.
- W2946973845 cites W4229743141 @default.
- W2946973845 cites W966510204 @default.
- W2946973845 doi "https://doi.org/10.1186/s12983-019-0312-2" @default.