FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2946987255> ?p ?o ?g. }

• W2946987255 abstract "Migraine is among the commonest causes of headache in all ages. It is the second most common cause of neurological disability. Currently, antihypertensive, antidepressants and antiepileptic drugs are reasonable preventable medications for chronic migraine. Despite the higher levels of stigma associated with this disease, fewer attempts were made in past regarding the treatment options for chronic migraine. Recently, a novelty treatment was introduced known as calcitonin gene-related peptide (CGRP) monoclonal antibodies as a possible mechanism for the prevention of migraine attacks. CGRP played an important role in the etiology of migraine headaches and was considered as the major peptide behind the cause of the headache disorders. We have reviewed the benefits of these monoclonal antibodies in terms of their efficacy and adverse effects with the available treatment choices. These drugs showed superior results when compared to the placebo and were considered generally safe in the majority of clinical trials. Earlier versions of CGRP antagonists, known as gepants, were less tolerable due to their tendency to cause liver and cardiovascular complications. Thus, in comparison to the earlier gepants, these CGRP monoclonal antibodies were safer and demonstrated excellent tolerability. Short-term side effects were only limited to mild-moderate injection site rash or pruritus, however, their long-term side effects are still unknown. Despite the higher cost of these drugs, we have analyzed the applicability of this drug in the developing countries. Although the quality-adjusted life year (QALY) gained per cost of the drug is still expensive and majority of people may not afford, its excellent tolerability and less adverse effects should also be considered a reason to implement this drug, particularly for resource-limited countries. Moreover, these medications could also become a prototype for future inventions and creations (cost-effective versions for resource-limited countries). In conclusion, this review suggests that CGRP monoclonal antibodies are safer and excellent alternate option for patients with chronic migraine as it has better efficacy, tolerability, and provides a hope to reduce the stigma associated with migraine. All these benefits should be the deciding factors when opting for this treatment and the decision should not be made solely on the socioeconomic status." @default.
• W2946987255 created "2019-06-07" @default.
• W2946987255 creator A5074237057 @default.
• W2946987255 date "2019-06-01" @default.
• W2946987255 modified "2023-10-14" @default.
• W2946987255 title "The Role of Anti-calcitonin Gene-related Peptide in Migraine and its Implication in Developing Countries: A Reasonable Option to Consider Despite Higher Cost" @default.
• W2946987255 cites W1802284765 @default.
• W2946987255 cites W1983283512 @default.
• W2946987255 cites W2012715161 @default.
• W2946987255 cites W2021017853 @default.
• W2946987255 cites W2025496772 @default.
• W2946987255 cites W2031081542 @default.
• W2946987255 cites W2063116792 @default.
• W2946987255 cites W2064963951 @default.
• W2946987255 cites W2087994192 @default.
• W2946987255 cites W2135858080 @default.
• W2946987255 cites W2162942726 @default.
• W2946987255 cites W2166206304 @default.
• W2946987255 cites W2317957978 @default.
• W2946987255 cites W2589422507 @default.
• W2946987255 cites W2737197277 @default.
• W2946987255 cites W2757941745 @default.
• W2946987255 cites W2808643415 @default.
• W2946987255 cites W2898958234 @default.
• W2946987255 cites W2900926854 @default.
• W2946987255 cites W2901687990 @default.
• W2946987255 doi "https://doi.org/10.7759/cureus.4796" @default.
• W2946987255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6679707" @default.
• W2946987255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31396466" @default.
• W2946987255 hasPublicationYear "2019" @default.
• W2946987255 type Work @default.
• W2946987255 sameAs 2946987255 @default.
• W2946987255 citedByCount "4" @default.
• W2946987255 countsByYear W29469872552020 @default.
• W2946987255 countsByYear W29469872552021 @default.
• W2946987255 countsByYear W29469872552023 @default.
• W2946987255 crossrefType "journal-article" @default.
• W2946987255 hasAuthorship W2946987255A5074237057 @default.
• W2946987255 hasBestOaLocation W29469872551 @default.
• W2946987255 hasConcept C118303440 @default.
• W2946987255 hasConcept C118552586 @default.
• W2946987255 hasConcept C126322002 @default.
• W2946987255 hasConcept C137627325 @default.
• W2946987255 hasConcept C142724271 @default.
• W2946987255 hasConcept C163170386 @default.
• W2946987255 hasConcept C170493617 @default.
• W2946987255 hasConcept C177713679 @default.
• W2946987255 hasConcept C187212893 @default.
• W2946987255 hasConcept C197934379 @default.
• W2946987255 hasConcept C204787440 @default.
• W2946987255 hasConcept C27081682 @default.
• W2946987255 hasConcept C2778375690 @default.
• W2946987255 hasConcept C2778541695 @default.
• W2946987255 hasConcept C2778570526 @default.
• W2946987255 hasConcept C2779627488 @default.
• W2946987255 hasConcept C2780035454 @default.
• W2946987255 hasConcept C2780966972 @default.
• W2946987255 hasConcept C71924100 @default.
• W2946987255 hasConcept C98274493 @default.
• W2946987255 hasConceptScore W2946987255C118303440 @default.
• W2946987255 hasConceptScore W2946987255C118552586 @default.
• W2946987255 hasConceptScore W2946987255C126322002 @default.
• W2946987255 hasConceptScore W2946987255C137627325 @default.
• W2946987255 hasConceptScore W2946987255C142724271 @default.
• W2946987255 hasConceptScore W2946987255C163170386 @default.
• W2946987255 hasConceptScore W2946987255C170493617 @default.
• W2946987255 hasConceptScore W2946987255C177713679 @default.
• W2946987255 hasConceptScore W2946987255C187212893 @default.
• W2946987255 hasConceptScore W2946987255C197934379 @default.
• W2946987255 hasConceptScore W2946987255C204787440 @default.
• W2946987255 hasConceptScore W2946987255C27081682 @default.
• W2946987255 hasConceptScore W2946987255C2778375690 @default.
• W2946987255 hasConceptScore W2946987255C2778541695 @default.
• W2946987255 hasConceptScore W2946987255C2778570526 @default.
• W2946987255 hasConceptScore W2946987255C2779627488 @default.
• W2946987255 hasConceptScore W2946987255C2780035454 @default.
• W2946987255 hasConceptScore W2946987255C2780966972 @default.
• W2946987255 hasConceptScore W2946987255C71924100 @default.
• W2946987255 hasConceptScore W2946987255C98274493 @default.
• W2946987255 hasLocation W29469872551 @default.
• W2946987255 hasLocation W29469872552 @default.
• W2946987255 hasLocation W29469872553 @default.
• W2946987255 hasLocation W29469872554 @default.
• W2946987255 hasOpenAccess W2946987255 @default.
• W2946987255 hasPrimaryLocation W29469872551 @default.
• W2946987255 hasRelatedWork W2003232156 @default.
• W2946987255 hasRelatedWork W2162942726 @default.
• W2946987255 hasRelatedWork W2589422507 @default.
• W2946987255 hasRelatedWork W2591456584 @default.
• W2946987255 hasRelatedWork W2955283194 @default.
• W2946987255 hasRelatedWork W2990089107 @default.
• W2946987255 hasRelatedWork W3004945021 @default.
• W2946987255 hasRelatedWork W3036029344 @default.
• W2946987255 hasRelatedWork W3142417963 @default.
• W2946987255 hasRelatedWork W3195126616 @default.
• W2946987255 isParatext "false" @default.
• W2946987255 isRetracted "false" @default.
• W2946987255 magId "2946987255" @default.
• W2946987255 workType "article" @default.