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- W2946989404 abstract "Abstract Reproduction is a fundamental imperative of all forms of life. For all the advantages sexual reproduction confers, it has a deeply conserved flaw: it is temperature sensitive. As temperatures rise, fertility decreases. Across species male fertility is particularly sensitive to elevated temperature. Previously we have shown in the model nematode worm C. elegans , that all males are fertile at 20°C but almost all males have lost fertility at 27°C. Male fertility is dependent on the production functional sperm, successful mating and transfer of sperm, and successful fertilization post-mating. To determine how male fertility is impacted by elevated temperature we analyzed these aspects of male reproduction at 27°C in three wild-type strains of C. elegans : JU1171, LKC34, and N2. We found no effect of elevated temperature on the number of immature non-motile spermatids formed. There was a weak effect of elevated temperature on sperm activation that may negatively impact sperm function. In stark contrast, there was a strong effect of elevated temperature on male mating behavior and sperm transfer such that males very rarely successfully completed mating when exposed to 27°C. Therefore, we propose a model where elevated temperature reduces male fertility due to the negative impacts of temperature on the somatic tissues necessary for mating. Loss of successful mating at elevated temperature overrides any effects that temperature may have on the germline or sperm cells." @default.
- W2946989404 created "2019-06-07" @default.
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- W2946989404 date "2019-05-31" @default.
- W2946989404 modified "2023-09-25" @default.
- W2946989404 title "Defects in mating behavior are the primary cause of sterility in C. elegans males at elevated temperature" @default.
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- W2946989404 doi "https://doi.org/10.1101/655027" @default.
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