FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947010024> ?p ?o ?g. }

• W2947010024 abstract "Abstract Male Cy/+ rats have shown a relatively consistent pattern of progressive kidney disease development that displays multiple key features of late stage chronic kidney disease-mineral bone disorder (CKD-MBD), specifically the development of cortical bone porosity. However, progression of disease in female Cy/+ rats, assessed in limited studies, is more heterogeneous and to date has failed to show development of the CKD-MBD phenotype, thus limiting their use as a practical model of progressive CKD-MBD. Animal and human studies suggest that estrogen may be protective against kidney disease in addition to its established protective effect on bone. Therefore, in this study, we aimed to determine the effect of ovariectomy (OVX) on the biochemical and skeletal manifestations of CKD-MBD in Cy/+ female rats. We hypothesized that OVX would accelerate development of the biochemical and skeletal features of CKD-MBD in female Cy/+ rats, similar to those seen in male Cy/+ rats. Female Cy/+ rats underwent OVX (n = 8) or Sham (n = 8) surgery at 15 weeks of age. Blood was collected every 5 weeks post-surgery until 35 weeks of age, when the rats underwent a 4-day metabolic balance, and the tibia and final blood were collected at the time of sacrifice. OVX produced the expected changes in trabecular and cortical parameters consistent with post-menopausal disease, and negative phosphorus balance compared with Sham. However, indicators of CKD-MBD were similar between OVX and Sham (similar kidney weight, plasma blood urea nitrogen, creatinine, creatinine clearance, phosphorus, calcium, parathyroid hormone, and no cortical porosity). Contrary to our hypothesis, OVX did not produce evidence of development of the CKD-MBD phenotype in female Cy/+ rats." @default.
• W2947010024 created "2019-06-07" @default.
• W2947010024 creator A5000603296 @default.
• W2947010024 creator A5019978739 @default.
• W2947010024 creator A5036155533 @default.
• W2947010024 creator A5044149723 @default.
• W2947010024 creator A5074473858 @default.
• W2947010024 creator A5074659892 @default.
• W2947010024 creator A5080453305 @default.
• W2947010024 creator A5082700641 @default.
• W2947010024 date "2019-05-28" @default.
• W2947010024 modified "2023-10-16" @default.
• W2947010024 title "Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats" @default.
• W2947010024 cites W123712461 @default.
• W2947010024 cites W149955126 @default.
• W2947010024 cites W1964220490 @default.
• W2947010024 cites W1977133287 @default.
• W2947010024 cites W1979835111 @default.
• W2947010024 cites W1988992751 @default.
• W2947010024 cites W2009905992 @default.
• W2947010024 cites W2012108748 @default.
• W2947010024 cites W2015110978 @default.
• W2947010024 cites W2027093084 @default.
• W2947010024 cites W2031050297 @default.
• W2947010024 cites W2038648112 @default.
• W2947010024 cites W2039232401 @default.
• W2947010024 cites W2042087675 @default.
• W2947010024 cites W2043817882 @default.
• W2947010024 cites W2044704215 @default.
• W2947010024 cites W2047825570 @default.
• W2947010024 cites W2047856826 @default.
• W2947010024 cites W2056977214 @default.
• W2947010024 cites W2058470362 @default.
• W2947010024 cites W2076732247 @default.
• W2947010024 cites W2088551072 @default.
• W2947010024 cites W2092668844 @default.
• W2947010024 cites W2094495606 @default.
• W2947010024 cites W2099455267 @default.
• W2947010024 cites W2102207664 @default.
• W2947010024 cites W2114225947 @default.
• W2947010024 cites W2119218375 @default.
• W2947010024 cites W2123295328 @default.
• W2947010024 cites W2137043925 @default.
• W2947010024 cites W2138171217 @default.
• W2947010024 cites W2141002983 @default.
• W2947010024 cites W2146544318 @default.
• W2947010024 cites W2156712321 @default.
• W2947010024 cites W2158222136 @default.
• W2947010024 cites W2163056783 @default.
• W2947010024 cites W2172159264 @default.
• W2947010024 cites W2330555746 @default.
• W2947010024 cites W2396605320 @default.
• W2947010024 cites W2470481127 @default.
• W2947010024 cites W2582602949 @default.
• W2947010024 cites W2789457489 @default.
• W2947010024 cites W2891466292 @default.
• W2947010024 cites W2980573868 @default.
• W2947010024 cites W924270864 @default.
• W2947010024 doi "https://doi.org/10.1038/s41598-019-44415-9" @default.
• W2947010024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6538713" @default.
• W2947010024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31138895" @default.
• W2947010024 hasPublicationYear "2019" @default.
• W2947010024 type Work @default.
• W2947010024 sameAs 2947010024 @default.
• W2947010024 citedByCount "13" @default.
• W2947010024 countsByYear W29470100242019 @default.
• W2947010024 countsByYear W29470100242020 @default.
• W2947010024 countsByYear W29470100242021 @default.
• W2947010024 countsByYear W29470100242022 @default.
• W2947010024 countsByYear W29470100242023 @default.
• W2947010024 crossrefType "journal-article" @default.
• W2947010024 hasAuthorship W2947010024A5000603296 @default.
• W2947010024 hasAuthorship W2947010024A5019978739 @default.
• W2947010024 hasAuthorship W2947010024A5036155533 @default.
• W2947010024 hasAuthorship W2947010024A5044149723 @default.
• W2947010024 hasAuthorship W2947010024A5074473858 @default.
• W2947010024 hasAuthorship W2947010024A5074659892 @default.
• W2947010024 hasAuthorship W2947010024A5080453305 @default.
• W2947010024 hasAuthorship W2947010024A5082700641 @default.
• W2947010024 hasBestOaLocation W29470100241 @default.
• W2947010024 hasConcept C126322002 @default.
• W2947010024 hasConcept C134018914 @default.
• W2947010024 hasConcept C2777164284 @default.
• W2947010024 hasConcept C2778176769 @default.
• W2947010024 hasConcept C2778653478 @default.
• W2947010024 hasConcept C2780091579 @default.
• W2947010024 hasConcept C2780306776 @default.
• W2947010024 hasConcept C2781208988 @default.
• W2947010024 hasConcept C519063684 @default.
• W2947010024 hasConcept C71924100 @default.
• W2947010024 hasConceptScore W2947010024C126322002 @default.
• W2947010024 hasConceptScore W2947010024C134018914 @default.
• W2947010024 hasConceptScore W2947010024C2777164284 @default.
• W2947010024 hasConceptScore W2947010024C2778176769 @default.
• W2947010024 hasConceptScore W2947010024C2778653478 @default.
• W2947010024 hasConceptScore W2947010024C2780091579 @default.
• W2947010024 hasConceptScore W2947010024C2780306776 @default.
• W2947010024 hasConceptScore W2947010024C2781208988 @default.
• W2947010024 hasConceptScore W2947010024C519063684 @default.
• W2947010024 hasConceptScore W2947010024C71924100 @default.

• next