FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2947014804> ?p ?o ?g. }

• W2947014804 endingPage "1486" @default.
• W2947014804 startingPage "1479" @default.
• W2947014804 abstract "Melatonin receptor agonists-ramelteon and melatonin-for bipolar disorder: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials Taro Kishi,1 Ikuo Nomura,1 Kenji Sakuma,1 Tsuyoshi Kitajima,1 Kazuo Mishima,2 Nakao Iwata11Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 2Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, JapanObjective: This study was a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials, investigating the efficacy and tolerability/safety of melatonin receptor agonists, such as ramelteon and melatonin, for patients with bipolar disorder.Methods: We carried out a literature search through PubMed and the Cochrane Library from the date of inception to January 6, 2019. The risk ratio (RR), number needed to treat (NNT), and standardized mean difference (SMD) ±95% CI were calculated. The primary outcome was all-cause discontinuation.Results: We identified three ramelteon (n=746) and two melatonin (n=53) studies. One of these two melatonin studies reported only data on all-cause discontinuation, whereas the other study did not report data relevant for a meta-analysis. We found no significant differences between the treatment and placebo groups regarding all-cause discontinuation, neither individually (p: ramelteon=0.86, melatonin=1.00) nor pooled together (p=0.85). Although we found no significant differences between ramelteon and placebo regarding the relapse due to mania/hypomania or mixed episode; Pittsburgh Sleep Quality Index scores; depression scales scores; Quality of Life Enjoyment and Satisfaction Questionnaire – Short Form scores; and the incidence of individual adverse events, such as headaches, insomnia, somnolence, anxiety, and dizziness, ramelteon was associated with a lower incidence of relapse due to depression than placebo (RR=0.67, 95% CI=0.48–0.94, p=0.02, NNT=14).Conclusion: Ramelteon might prevent relapse due to depression in patients with bipolar disorder. However, because of the small number of studies included in the present systematic review and meta-analysis, further studies comparing ramelteon and placebo with larger samples of patients with bipolar disorder are warranted. We also did not evaluate the efficacy and safety of melatonin for patients with bipolar disorder in detail.Keywords: ramelteon, melatonin, bipolar disorder, relapse, systematic review, meta-analysis" @default.
• W2947014804 created "2019-06-07" @default.
• W2947014804 creator A5015137967 @default.
• W2947014804 creator A5018647067 @default.
• W2947014804 creator A5025793368 @default.
• W2947014804 creator A5040100205 @default.
• W2947014804 creator A5047193478 @default.
• W2947014804 creator A5087930175 @default.
• W2947014804 date "2019-05-01" @default.
• W2947014804 modified "2023-09-27" @default.
• W2947014804 title "<p>Melatonin receptor agonists—ramelteon and melatonin—for bipolar disorder: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials</p>" @default.
• W2947014804 cites W143336295 @default.
• W2947014804 cites W1594539812 @default.
• W2947014804 cites W1989460808 @default.
• W2947014804 cites W2042049452 @default.
• W2947014804 cites W2054823538 @default.
• W2947014804 cites W2065962732 @default.
• W2947014804 cites W2073657349 @default.
• W2947014804 cites W2076171836 @default.
• W2947014804 cites W2107328434 @default.
• W2947014804 cites W2118761224 @default.
• W2947014804 cites W2125435699 @default.
• W2947014804 cites W2127124395 @default.
• W2947014804 cites W2131823335 @default.
• W2947014804 cites W2145141773 @default.
• W2947014804 cites W2151487996 @default.
• W2947014804 cites W2156098321 @default.
• W2947014804 cites W2167659819 @default.
• W2947014804 cites W2170882187 @default.
• W2947014804 cites W2182989897 @default.
• W2947014804 cites W2320387752 @default.
• W2947014804 cites W2415900954 @default.
• W2947014804 cites W2548900044 @default.
• W2947014804 cites W2587621593 @default.
• W2947014804 cites W2606300313 @default.
• W2947014804 cites W2626454688 @default.
• W2947014804 cites W2671500876 @default.
• W2947014804 cites W2792027821 @default.
• W2947014804 cites W2806861601 @default.
• W2947014804 cites W2885968043 @default.
• W2947014804 cites W2991792334 @default.
• W2947014804 cites W4211069648 @default.
• W2947014804 doi "https://doi.org/10.2147/ndt.s198899" @default.
• W2947014804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6553999" @default.
• W2947014804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31239683" @default.
• W2947014804 hasPublicationYear "2019" @default.
• W2947014804 type Work @default.
• W2947014804 sameAs 2947014804 @default.
• W2947014804 citedByCount "15" @default.
• W2947014804 countsByYear W29470148042019 @default.
• W2947014804 countsByYear W29470148042020 @default.
• W2947014804 countsByYear W29470148042021 @default.
• W2947014804 countsByYear W29470148042022 @default.
• W2947014804 countsByYear W29470148042023 @default.
• W2947014804 crossrefType "journal-article" @default.
• W2947014804 hasAuthorship W2947014804A5015137967 @default.
• W2947014804 hasAuthorship W2947014804A5018647067 @default.
• W2947014804 hasAuthorship W2947014804A5025793368 @default.
• W2947014804 hasAuthorship W2947014804A5040100205 @default.
• W2947014804 hasAuthorship W2947014804A5047193478 @default.
• W2947014804 hasAuthorship W2947014804A5087930175 @default.
• W2947014804 hasBestOaLocation W29470148041 @default.
• W2947014804 hasConcept C118552586 @default.
• W2947014804 hasConcept C126322002 @default.
• W2947014804 hasConcept C142724271 @default.
• W2947014804 hasConcept C168563851 @default.
• W2947014804 hasConcept C197934379 @default.
• W2947014804 hasConcept C204787440 @default.
• W2947014804 hasConcept C27081682 @default.
• W2947014804 hasConcept C2776174506 @default.
• W2947014804 hasConcept C2776809841 @default.
• W2947014804 hasConcept C2778182776 @default.
• W2947014804 hasConcept C2778375690 @default.
• W2947014804 hasConcept C2778567577 @default.
• W2947014804 hasConcept C2778715236 @default.
• W2947014804 hasConcept C2779177272 @default.
• W2947014804 hasConcept C2780733359 @default.
• W2947014804 hasConcept C2780798758 @default.
• W2947014804 hasConcept C2781269140 @default.
• W2947014804 hasConcept C558461103 @default.
• W2947014804 hasConcept C71924100 @default.
• W2947014804 hasConcept C98274493 @default.
• W2947014804 hasConceptScore W2947014804C118552586 @default.
• W2947014804 hasConceptScore W2947014804C126322002 @default.
• W2947014804 hasConceptScore W2947014804C142724271 @default.
• W2947014804 hasConceptScore W2947014804C168563851 @default.
• W2947014804 hasConceptScore W2947014804C197934379 @default.
• W2947014804 hasConceptScore W2947014804C204787440 @default.
• W2947014804 hasConceptScore W2947014804C27081682 @default.
• W2947014804 hasConceptScore W2947014804C2776174506 @default.
• W2947014804 hasConceptScore W2947014804C2776809841 @default.
• W2947014804 hasConceptScore W2947014804C2778182776 @default.
• W2947014804 hasConceptScore W2947014804C2778375690 @default.
• W2947014804 hasConceptScore W2947014804C2778567577 @default.
• W2947014804 hasConceptScore W2947014804C2778715236 @default.
• W2947014804 hasConceptScore W2947014804C2779177272 @default.
• W2947014804 hasConceptScore W2947014804C2780733359 @default.
• W2947014804 hasConceptScore W2947014804C2780798758 @default.

• next